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Chemical Structure| 18103-98-5 Chemical Structure| 18103-98-5

Structure of 18103-98-5

Chemical Structure| 18103-98-5

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Product Details of [ 18103-98-5 ]

CAS No. :18103-98-5
Formula : C12H15NO
M.W : 189.25
SMILES Code : O=C(C1=CC=C(C)C=C1)C=CN(C)C
MDL No. :MFCD00121190

Safety of [ 18103-98-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 18103-98-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18103-98-5 ]

[ 18103-98-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 580-15-4 ]
  • [ 18103-98-5 ]
  • 3-(quinolin-6-ylamino)-1-(p-tolyl)prop-2-en-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With potassium hydrogensulfate; In ethanol; water; at 20℃; for 0.166667h;Sonication; General procedure: To a mixture of 3-aminoquinoline (1 mmol) and enaminones4a (1 mmol) in 6 cm3of EtOH: H2O(1:1) taken in a roundbottomflask was added KHSO4(2 mmol) and the resultingmixture was irradiated in an ultrasound cleaner for 10 minat room temperature when a solid product precipitated out.The progress and completion of the reaction was monitoredby TLC. The precipitate was collected by filtration withrepeated washing with water to ensure complete removal ofthe acid and then dried to give a practically pure 5a in 89%yield. Further purification of 5a was carried out by silicagel column chromatography using 50% EtOAc-hexane.The rest of the enaminones 5b-5e, 6a-6e, and 7a-7e wereequally easily prepared in 10-12 min in 79-94% overallyields. The structures of these enaminones were unambiguouslyassigned with the help of analytical and spectral datapresented hereunder.
 

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