Alternatived Products of [ 182880-24-6 ]
Product Details of [ 182880-24-6 ]
CAS No. : | 182880-24-6 |
MDL No. : | MFCD09998268 |
Formula : |
C9H8N2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
176.17
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 182880-24-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 182880-24-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 182880-24-6 ]
- 1
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[ 16064-10-1 ]
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trichlorophosphate
[ No CAS ]
-
[ 182880-24-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium methylate; sodium In methanol |
52.Y Y
Y 6-Hydroxy-4-methoxyquinazoline A mixture of 200 mg of 6-hydroxy-3H-quinazolin-4-one and 5 ml of phosphorylchloride is heated to reflux for 2 hours. The excess phosphorylchloride is distilled off in vacuo and the residue is taken up in a solution of sodium methoxide (prepared from 80 mg sodium) in dry methanol. After refluxing for 2 hours the solvent is distilled off and the residue is partitioned between aqueous ph7-buffer solution and ethyl acetate. The organic phase is separated, dried over magnesium sulfate and evaporated in vacuo. The crude product is directly used in the next reaction or purified by chromatography on silica gel. 1 H-NMR (d6 -DMSO): 10.25 (br.s, 1H); 8.61 (s, 1H); 7.79 (d, J=9 Hz, 1H); 7.45 (dd,J=2.8+9 Hz, 1H); 7.32 (d,J=2.8 Hz, 1H); 4.09 (s,3H). |