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[ CAS No. 183673-66-7 ]

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Chemical Structure| 183673-66-7
Chemical Structure| 183673-66-7
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CAS No. :183673-66-7 MDL No. :MFCD01318741
Formula : C26H30N2O6 Boiling Point : 657.8°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :466.53 g/mol Pubchem ID :2734399
Synonyms :

Safety of [ 183673-66-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 183673-66-7 ]

  • Upstream synthesis route of [ 183673-66-7 ]
  • Downstream synthetic route of [ 183673-66-7 ]

[ 183673-66-7 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 183673-66-7 ]
  • [ 406235-17-4 ]
  • [ 161529-14-2 ]
Reference: [1] Patent: US2002/55631, 2002, A1,
[2] Patent: US2002/86887, 2002, A1,
  • 2
  • [ 28920-43-6 ]
  • [ 183673-71-4 ]
  • [ 183673-66-7 ]
YieldReaction ConditionsOperation in experiment
42% With sodium carbonate In tetrahydrofuran at 0 - 25℃; for 12 h; 4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1-(tert- butoxycarbonyl)piperidine-4-carboxylic acid (Scheme 1, compound 8) [0225] A solution of 4-amino-1 -(terf-butoxycarbonyl)piperidine-4- carboxylic acid (5 g, 20.5 mmol) in THF (300 mL) and Na2CO3 (6.45 g, 61 .5 mmol, 3.0 eq in 64.5 mL of water) was cooled to 0°C before the dropwise addition of a solution of Fmoc chloride (5.3 g, 30.7 mmol, 1 .5 eq) in THF (30 mL). The resulting mixture was slowly warmed to 25°C and stirred for an additional 12 hours. Upon completion, the reaction contents were carefully acidified with HCI (1 M), and the crude material was extracted with EtOAc (three times). The combined organic layers were dried (Na2SO4), concentrated, and the crude material was purified by combiflash 0 to 10percent MeOH in DCM to provide 4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1 -(te/t- butoxycarbonyl)piperidine-4-carboxylic acid (Scheme 1 , compound 8) (4.02 g, 42percent yield). [0226] 1 H NMR (400 MHz, Ch lore-form -c/) δ 7.75 (d, J = 7.5 Hz, 2H), 7.57 (d, J = 7.5 Hz, 2H), 7.45-7.34 (m, 2H), 7.30 (td, J = 6.9, 6.3, 1 .4 Hz, 2H), 4.68-4.26 (m, 2H), 4.19 (t, J = 6.5 Hz, 1 H), 3.96-3.65 (m, 3H), 3.08 (s, 2H), 1 .91 -1 .77 (m, 2H), 1 .48 (s, 9H). 13C NMR (101 MHz, CDCI3) 177.19, 154.73, 143.67, 141 .32, 127.72, 127.08, 124.95, 1 19.97, 80.06, 67.90, 66.86, 57.49, 47.19, 31 .98, 28.42, 25.57. HRMS (m/z): [M+] cald for C26H30N2O6, 466.53, found 466.2
Reference: [1] Organic Syntheses, 2005, vol. 81, p. 213 - 224
[2] Patent: WO2015/184349, 2015, A2, . Location in patent: Paragraph 0225-0226
  • 3
  • [ 82911-69-1 ]
  • [ 183673-71-4 ]
  • [ 183673-66-7 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5694 - 5706
  • 4
  • [ 40064-34-4 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
[2] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 5
  • [ 24424-99-5 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 6
  • [ 79099-07-3 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 7
  • [ 13625-39-3 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 8
  • [ 183673-70-3 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 9
  • [ 183673-68-9 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 10
  • [ 102774-86-7 ]
  • [ 183673-71-4 ]
  • [ 183673-66-7 ]
Reference: [1] Journal of Organic Chemistry, 1996, vol. 61, # 22, p. 7650 - 7651
  • 11
  • [ 183673-66-7 ]
  • [ 368866-09-5 ]
Reference: [1] Patent: WO2011/153588, 2011, A1, . Location in patent: Page/Page column 49
[2] ChemBioChem, 2016, vol. 17, # 2, p. 137 - 140
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