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Chemical Structure| 184357-44-6 Chemical Structure| 184357-44-6

Structure of 184357-44-6

Chemical Structure| 184357-44-6

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Product Details of [ 184357-44-6 ]

CAS No. :184357-44-6
Formula : C10H21NO3
M.W : 203.28
SMILES Code : O=C(OC(C)(C)C)NCC(C)(C)CO
MDL No. :MFCD09951814
InChI Key :BHIGZYWRVWZUHG-UHFFFAOYSA-N
Pubchem ID :21263232

Safety of [ 184357-44-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Application In Synthesis of [ 184357-44-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 184357-44-6 ]

[ 184357-44-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 184357-44-6 ]
  • [ 180181-02-6 ]
YieldReaction ConditionsOperation in experiment
Reference Example 68Benzyl 3-amino-2,2-di(methyl)propionate To a solution of 3-amino-2,2-dimethyl-1-propanol (5 g) in methanol (50 mL) was added di-tert-butyl dicarbonate (12.7 g), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure. The residue (solid) was treated with n-hexane-diethyl ether and collected by filtration, washed with n-hexane and dried under reduced pressure to give 3-(tert-butoxycarbonylamino)-2,2-dimethyl-1-propanol (7.48 g). To this material were added carbon tetrachloride (40 mL), acetonitrile (40 mL), water (48 mL), sodium periodate (38.8 g) and ruthenium trichloride-n hydrate (1 g) successively, and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine. To the organic layer was added a saturated aqueous potassium carbonate solution, and the aqueous layer was separated. The aqueous layer was acidified with 2 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 3-(tert-butoxycarbonylamino)-2,2-di(methyl)propionic acid (2.78 g). This material was dissolved in N,N-dimethylformamide (30 mL). To the solution were added potassium carbonate (3.54 g) and benzyl bromide (2.28 mL), and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate = 2/1) to give benzyl 3-(tert-butoxycarbonylamino)-2,2-di(methyl)propionate (2.72 g). To this material was added hydrochloric acid (4 mol/L 1,4-dioxane solution, 10 mL), and the mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure. To the residue was added a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (1.61 g).1HNMR (DMSO-d6) delta ppm: 1.09 (6H, s), 1.35-1.7 (2H, br), 2.63 (2H, s), 5.09 (2H, s), 7.25-7.45 (5H, m)
 

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