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Chemical Structure| 18436-69-6 Chemical Structure| 18436-69-6

Structure of 18436-69-6

Chemical Structure| 18436-69-6

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Product Details of [ 18436-69-6 ]

CAS No. :18436-69-6
Formula : C12H10ClNO2
M.W : 235.67
SMILES Code : O=C(C1=NC2=CC=CC=C2C(Cl)=C1)OCC
MDL No. :MFCD08445412
InChI Key :POWYXUDTZJAGFL-UHFFFAOYSA-N
Pubchem ID :269156

Safety of [ 18436-69-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 18436-69-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18436-69-6 ]

[ 18436-69-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24782-43-2 ]
  • [ 18436-69-6 ]
YieldReaction ConditionsOperation in experiment
With trichlorophosphate; at 100℃; for 0.5h;Microwave irradiation; Intermediate 10; Ethyl 4-chloroquinoline-2-carboxylatePhosphorous oxychloride (5ml) was added to <strong>[24782-43-2]ethyl 4-hydroxyquinoline-2-carboxylate</strong> (l.Olg). The reaction mixture was subjected to single-mode microwave at 100 0C for 30 min using a Smith Microwave Synthesizer. The solvent was removed in vacuo and recrystallized with acetone to gave the title compound as a white solid (1.9Og). MS (ES) MH+: 235, 237 for C12Hi0ClNO2; NMR (CDCl3): 1.44 (t, 3H, J = 7.16), 4.51 (q, 2H, J = 7.16), 7.19 (s, IH), 7.71 (m, IH), 7.81 (m, IH), 8.22 (m, IH), 8.36 (d, IH, J = 8.29).
 

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