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[ CAS No. 186772-43-0 ] {[proInfo.proName]}

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Quality Control of [ 186772-43-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 186772-43-0 ]

Product Details of [ 186772-43-0 ]

CAS No. :	186772-43-0	MDL No. :	MFCD18089329
Formula :	C₁₀H₁₂BrI	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QOBRAZDMDGZKHL-UHFFFAOYSA-N
M.W :	339.01	Pubchem ID :	11461895
Synonyms :

Safety of [ 186772-43-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338-P304+P340	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 186772-43-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 186772-43-0 ]

[ 186772-43-0 ] Synthesis Path-Downstream 1~49

1
[ 191983-33-2 ]
[ 186772-43-0 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

2
[ 186772-43-0 ]
[ 1066-54-2 ]
[ 144001-06-9 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

3
[ 89343-06-6 ]
[ 186772-43-0 ]
[ 863782-50-7 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

4
[ 186772-43-0 ]
[ 863782-54-1 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

5
[ 186772-43-0 ]
[ 863782-52-9 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

6
[ 186772-43-0 ]
[ 863782-53-0 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

7
[ 186772-43-0 ]
(2-{3-<i>tert</i>-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

8
[ 186772-43-0 ]
[ 863782-56-3 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

9
[ 186772-43-0 ]
[ 863782-55-2 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

10
[ 186772-43-0 ]
[ 863782-51-8 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

11
[ 186772-43-0 ]
C₂₉H₃₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

12
[ 186772-43-0 ]
[ 863782-58-5 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

13
[ 186772-43-0 ]
[ 863782-59-6 ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

14
[ 186772-43-0 ]
C₄₇H₇₂Si₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

15
[ 186772-43-0 ]
C₄₇H₇₂Si₂ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

16
[ 186772-43-0 ]
C₅₈H₆₀ [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2005,vol. 44,p. 4039 - 4042

17
[ 769-92-6 ]
[ 186772-43-0 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083

18
[ 103273-01-4 ]
[ 186772-43-0 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

19
[ 20330-45-4 ]
[ 186772-43-0 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

20
[ 91801-97-7 ]
[ 186772-43-0 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

21
[ 186772-43-0 ]
[ 186772-47-4 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

22
[ 186772-43-0 ]
[ 186772-49-6 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[3]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

23
[ 186772-43-0 ]
[ 186772-54-3 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

24
[ 186772-43-0 ]
[ 186772-45-2 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

25
[ 186772-43-0 ]
[ 388092-70-4 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[3]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

26
[ 186772-43-0 ]
[ 186772-55-4 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083

27
[ 186772-43-0 ]
[ 388092-72-6 ]

Reference： [1]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[2]Tetrahedron,2001,vol. 57,p. 8075 - 8083
[3]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328
[4]Tetrahedron Letters,1996,vol. 37,p. 9325 - 9328

28
[ 186772-43-0 ]
1,1′-(5,5’‘-di-tert-butyl[1,1′:3′,1’‘-terphenyl]-3,3’‘-diyl)bis(2-iodo-3-methyl-1H-imidazol-3-ium) bis(trifluoromethanesulfonate) [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672
[2]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

29
[ 186772-43-0 ]
1-(3’‘,5-di-tert-butyl-5’‘-(3-methyl-1H-imidazol-3-ium-1-yl)[1,1′:3′,1’‘-terphenyl]-3-yl)-2-iodo-3-methyl-1H-imidazol-3-ium bis(trifluoromethanesulfonate) [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

30
[ 186772-43-0 ]
1,1′-(5,5’‘-di-tert-butyl[1,1′:3′,1’‘-terphenyl]-3,3’‘-diyl)bis(3-methyl-1H-imidazol-3-ium) bis(trifluoromethanesulfonate) [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

31
[ 186772-43-0 ]
1,1′-(5,5’‘-di-tert-butyl-[1,1′:3′,1’‘-terphenyl]-3,3’‘-diyl)bis(1H-imidazole) [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

32
[ 186772-43-0 ]
1,1′-(5,5’‘-di-tert-butyl[1,1′:3′,1’‘-terphenyl]-3,3’‘-diyl)bis(2-iodo-1H-imidazole) [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672
[2]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

33
[ 186772-43-0 ]
1-(3’‘,5-di-tert-butyl-5’‘-(1H-imidazol-1-yl)[1,1′:3′,1’‘-terphenyl]-3-yl)-2-iodo-1H-imidazole [ No CAS ]

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

34
[ 288-32-4 ]
[ 186772-43-0 ]
1-(3-bromo-5-(tert-butyl)phenyl)-1H-imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85.7%	With copper(I) oxide; salicylaldehyde-oxime; caesium carbonate; In acetonitrile; at 50℃;Schlenk technique; Inert atmosphere;	General procedure: Salicylaldoxime (0.2 equiv), imidazole (1.2 equiv), Cs2CO3 (2.0equiv), and Cu2O (0.1 equiv) were added to an oven driedSchlenk tube under an inert atmosphere (dry N2). A spargedsolution of <strong>[186772-43-0]1-bromo-3-(tert-butyl)-5-iodobenzene</strong> (8) (preparedby a known procedure (19)), or 1-bromo-3-iodobenzene(8a) (1 equiv, 0.8 M in total reaction mixture) dissolved in dryacetonitrile was then added to the Schlenk tube using a cannulaand the clear reaction mixture with Cu2O and Cs2CO3suspension was raised to 50 C in an oil bath and left to stirfor 25 h. The solution was then allowed to cool to rt beforediluting with DCM and filtering through diatomaceous earth.The product was then purified by flash column chromatographyusing normal phase silica, and/or by vacuum distillationat 1 Torr.

Reference： [1]Supramolecular Chemistry,2016,vol. 28,p. 665 - 672

35
[ 67-56-1 ]
[ 186772-43-0 ]
[ 1047661-27-7 ]

Yield	Reaction Conditions	Operation in experiment
75%	With copper(l) iodide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; at 100℃; for 18h;Sealed tube;	9.0 g (27.2 mmol) of Intermediate 5-6 and 150 ml of methyl alcohol were mixed, and 0.5 g (2.7 mmol) of CuI, 17.7 g (54.5 mmol) of Cs2CO3, and 1.3 g (5.5 mmol) of 4,7-dimethoxy-1,10-phenanthroline were added thereto. The reaction mixture was stirred in a seal-tube at 100C. for 18 hours. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, and the organic layer was extracted therefrom by using dichloromethane and water. The extracted organic layer was dried by using magnesium sulfate, distilled under reduced pressure, and purified by liquid chromatography to obtain 5 g (20.4 mmol, yield: 75%) of Intermediate 5-5. LC-MS m/z=244 (M+H)+.

Reference： [1]Patent: US2019/194237,2019,A1 .Location in patent: Paragraph 0369; 0372; 0373

36
[ 186772-43-0 ]
[ 1047661-26-6 ]

Reference： [1]Patent: US2019/194237,2019,A1

37
[ 186772-43-0 ]
C₂₀H₂₄Br₂O [ No CAS ]

Reference： [1]Patent: US2019/194237,2019,A1

38
[ 1047661-26-6 ]
[ 186772-43-0 ]
C₂₀H₂₄Br₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 120℃; for 18h;	4.5 g (19.5 mmol) of Intermediate 5-4 and 7.0 g (19.5 mmol) of Intermediate 5-6 were mixed with 100 ml of DMSO, and 0.4 g (2.0 mmol) of CuI, 0.5 g (4.0 mmol) of picolinic acid, and 8.3 g (39.0 mmol) of K3PO4 added thereto. The reaction mixture was heated at a temperature of 120C. for 18 hours. After the reaction was completed, a saturated NaCl aqueous solution was added thereto to extract the organic layer. The extracted organic layer was dried by using magnesium sulfate, distilled under reduced pressure, and purified by liquid chromatography to obtain 5.5 g (12.7 mmol, yield: 65%) of Intermediate 5-3. LC-MS m/z=535 (M+H)+.

Reference： [1]Patent: US2019/194237,2019,A1 .Location in patent: Paragraph 0369; 0376; 0377

39
[ 129316-09-2 ]
[ 186772-43-0 ]

Yield	Reaction Conditions	Operation in experiment
60%		17.7 g (60.47 mmol) of <strong>[129316-09-2]1,3-dibromo-5-(tert-butyl)benzene</strong> was mixed with 200 ml of diethyl ether, and n-BuLi (1.6 M in hexane) was slowly added thereto at a temperature of -78C. After the reaction mixture was stirred at a temperature of -78C. for 1 hour, 15 g (72.6 mmol) of iodine mixed with 20 ml of THF was slowly added by drops thereto. The reaction mixture was stirred at room temperature for 16 hours. After the reaction was completed, the organic layer was extracted by using ethyl acetate and a sodium thiosulfate aqueous solution, dried by using magnesium sulfate, distilled under reduced pressure, and purified by liquid chromatography to obtain 18 g (54.5 mmol, yield: 60%) of Intermediate 5-6. LC-MS m/z=291 (M+H)+.

Reference： [1]Patent: US2019/194237,2019,A1 .Location in patent: Paragraph 0369; 0370; 0371
[2]ACS Medicinal Chemistry Letters,2020

40
[ 186772-43-0 ]
C₂₆H₂₇N₃O₂ [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2020,vol. 11,p. 379 - 384

41
[ 186772-43-0 ]
C₂₆H₃₅BO₄ [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2020,vol. 11,p. 379 - 384

42
[ 186772-43-0 ]
3'-(tert-butyl)-6-ethyl-5'-(imidazo[1,2-a]pyrazin-3-yl)-N-(3-(trifluoromethyl)phenyl)-[1,1'-biphenyl]-3-carboxamide [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2020,vol. 11,p. 379 - 384

43
methyl 4-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate [ No CAS ]
[ 186772-43-0 ]
C₂₀H₂₃BrO₂ [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2020,vol. 11,p. 379 - 384

44
[ 62-53-3 ]
[ 186772-43-0 ]
C₂₂H₂₄N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 24h;Reflux;	In a L reactor, 50 g (177 mmol) of <strong>[186772-43-0]1-bromo-3(tert-butyl)-5-iodobenzene</strong>,Aniline 36.2 g (389 mmol),1.6 g (7 mmol) of palladium acetate,51 g (530 mmol) of sodium tert-butoxide,Bis(diphenylphosphino)-1,1'-binaphthyl 4.4 g (7 mmol),500 mL of toluene was added, and the mixture was stirred under reflux for 24 hours.After completion of the reaction, the filtrate is concentrated by filtration,Separation by column chromatography gave 42.5 g of .Intermediate 3-a (Yield 50%)
50%	With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 24h;Reflux;	1-Bromo-3(tert-butyl)-5-iodobenzene (50 g, 177 mmol), aniline (36.2 g, 389 mmol), palladium acetate (1.6 g, 7 mmol), sodium tert-butoxide (51 g, 530 mmol), bis(diphenylphosphino)-1,1?-binaphthyl (4.4 g, 7 mmol), and toluene (500 mL) were placed in a 1 L reactor. The mixture was refluxed with stirring for 24 h. After completion of the reaction, the reaction mixture was filtered. The filtrate was concentrated and purified by column chromatography to afford Intermediate 3-a (42.5 g, yield 50%).

Reference： [1]Patent: JP2020/83896,2020,A .Location in patent: Paragraph 0160-0164
[2]Patent: US2020/172558,2020,A1 .Location in patent: Paragraph 0099-0100

45
[ 186772-43-0 ]
C₃₈H₃₂N₂O₂ [ No CAS ]

Reference： [1]Patent: JP2020/83896,2020,A

46
[ 186772-43-0 ]
C₃₈H₂₉BN₂O₂ [ No CAS ]

Reference： [1]Patent: JP2020/83896,2020,A

47
[ 62-53-3 ]
[ 186772-43-0 ]
C₃₈H₃₂N₂O₂ [ No CAS ]

Reference： [1]Patent: US2020/172558,2020,A1

48
[ 5599-71-3 ]
[ 186772-43-0 ]
C₂₂H₁₈BrCl₂N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With tripotassium phosphate tribasic; copper (I) iodide; rac-diaminocyclohexane In 1,4-dioxane at 85℃; for 1.5h; Inert atmosphere;	Intermediate 15-1 To a solution of 26.4 g (78.0 mmol) of Intermediate 7-1 in 250 mL of 1,4-dioxane was added 15.35 g (65.0 mmol) of 3,6-dichloro-9H-carbazole, 41.4 g (195.0 mmol) of potassium phos phate, 1.55 g (8.13 mmol) of copper iodide, 2.73 mL (22.75 mmol) of cyclohexane-1 ,2-diamine. The suspension was degassed with Ar, then heated to 85°C for 1.5 hours. After cooling to room temperature, the suspension was filtered over celite, rinsing with warm toluene (4x100 mL). The filtrate was evaporated, and the resulting residue was purified by silica-gel column chromatog raphy using heptanes as eluent. The resulting white solid was further recrystallized from cyclo hexane (2x150 mL) to give 14.66 g (80% yield) of Intermediate 15-1 as a white solid. 1H NMR (300 MHz, chloroform-o d 8.05 (dd, 2H), 7.67 (t, 1H), 7.50 (dt, 2H), 7.42 (dd, 2H), 7.32 (dd, 2H), 1.41 (s, 9H).
80%	With tripotassium phosphate tribasic; copper (I) iodide; rac-diaminocyclohexane In 1,4-dioxane at 85℃; for 1.5h; Inert atmosphere;	Intermediate 15-1 To a solution of 26.4 g (78.0 mmol) of Intermediate 7-1 in 250 mL of 1,4-dioxane was added 15.35 g (65.0 mmol) of 3,6-dichloro-9H-carbazole, 41.4 g (195.0 mmol) of potassium phos phate, 1.55 g (8.13 mmol) of copper iodide, 2.73 mL (22.75 mmol) of cyclohexane-1 ,2-diamine. The suspension was degassed with Ar, then heated to 85°C for 1.5 hours. After cooling to room temperature, the suspension was filtered over celite, rinsing with warm toluene (4x100 mL). The filtrate was evaporated, and the resulting residue was purified by silica-gel column chromatog raphy using heptanes as eluent. The resulting white solid was further recrystallized from cyclo hexane (2x150 mL) to give 14.66 g (80% yield) of Intermediate 15-1 as a white solid. 1H NMR (300 MHz, chloroform-o d 8.05 (dd, 2H), 7.67 (t, 1H), 7.50 (dt, 2H), 7.42 (dd, 2H), 7.32 (dd, 2H), 1.41 (s, 9H).
80%	With tripotassium phosphate tribasic; copper (I) iodide; rac-diaminocyclohexane In 1,4-dioxane at 85℃; for 1.5h; Inert atmosphere;	Intermediate 15-1 To a solution of 26.4 g (78.0 mmol) of Intermediate 7-1 in 250 mL of 1,4-dioxane was added 15.35 g (65.0 mmol) of 3,6-dichloro-9H-carbazole, 41.4 g (195.0 mmol) of potassium phos phate, 1.55 g (8.13 mmol) of copper iodide, 2.73 mL (22.75 mmol) of cyclohexane-1 ,2-diamine. The suspension was degassed with Ar, then heated to 85°C for 1.5 hours. After cooling to room temperature, the suspension was filtered over celite, rinsing with warm toluene (4x100 mL). The filtrate was evaporated, and the resulting residue was purified by silica-gel column chromatog raphy using heptanes as eluent. The resulting white solid was further recrystallized from cyclo hexane (2x150 mL) to give 14.66 g (80% yield) of Intermediate 15-1 as a white solid. 1H NMR (300 MHz, chloroform-o d 8.05 (dd, 2H), 7.67 (t, 1H), 7.50 (dt, 2H), 7.42 (dd, 2H), 7.32 (dd, 2H), 1.41 (s, 9H).

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - WO2021/255698, 2021, A1 Location in patent: Page/Page column 139
[2]Current Patent Assignee: IDEMITSU KOSAN CO LTD - WO2021/255698, 2021, A1 Location in patent: Page/Page column 139
[3]Current Patent Assignee: IDEMITSU KOSAN CO LTD - WO2021/255698, 2021, A1 Location in patent: Page/Page column 139

49
[ 1510810-80-6 ]
[ 186772-43-0 ]
C₃₀H₃₆BrN [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With tetrakis-(triphenylphosphine)-palladium; sodium hydroxide In tetrahydrofuran; lithium hydroxide monohydrate for 1.5h; Inert atmosphere; Reflux;	Intermediate 24-1 4.07 g (12.0 mmol) of Intermediate 7-1, 4.13 g (10.2 mmol) of Intermediate 2-3, 0.96 g (24.0 mmol) of sodium hydroxide were suspended in a mixture of tetrahydrofuran/water (54/27 ml_). The suspension was degassed with Ar, and 277 mg (2mol%) of tetrakis(triphenylphosphine)pal- ladium(O) were added to the reaction mixture. The reaction mixture was refluxed for 1.5 hours. The reaction was cooled to room temperature and diluted with toluene/water. The layers were separated, and the water layer was further extracted with toluene. The organic extracts were washed with water, brine and dried over sodium sulfate, filtered and evaporated. The residue was purified by silica-gel column chromatography using heptanes/toluene as eluent to give 4.30 g (73%yield) of Intermediate 24-1 as a white foam. ESI-MS:490.2 [M-H]-

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - WO2021/255698, 2021, A1 Location in patent: Page/Page column 155-156

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Ghs Precautionary Statements

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Code	Phrase
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P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere