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[ CAS No. 18706-21-3 ]

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2D 3D

Chemical Structure| 18706-21-3

Chemical Structure| 18706-21-3

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Quality Control of [ 18706-21-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 18706-21-3 ]

SDS Specification

Alternatived Products of [ 18706-21-3 ]

Product Details of [ 18706-21-3 ]

CAS No. :	18706-21-3	MDL No. :	MFCD00276583
Formula :	C₁₀H₅ClF₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MGEMMMJZAWYWNI-UHFFFAOYSA-N
M.W :	247.60 g/mol	Pubchem ID :	2736609
Synonyms :

Calculated chemistry of [ 18706-21-3 ]

Physicochemical Properties

Num. heavy atoms :	16
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.1
Num. rotatable bonds :	1
Num. H-bond acceptors :	5.0
Num. H-bond donors :	1.0
Molar Refractivity :	53.78
TPSA :	33.12 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.41 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.85
Log Po/w (XLOGP3) :	3.38
Log Po/w (WLOGP) :	4.76
Log Po/w (MLOGP) :	2.74
Log Po/w (SILICOS-IT) :	3.56
Consensus Log Po/w :	3.26

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.9
Solubility :	0.0311 mg/ml ; 0.000126 mol/l
Class :	Soluble
Log S (Ali) :	-3.75
Solubility :	0.0436 mg/ml ; 0.000176 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.63
Solubility :	0.00575 mg/ml ; 0.0000232 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.59

Safety of [ 18706-21-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 18706-21-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 18706-21-3 ]

[ 18706-21-3 ] Synthesis Path-Downstream 1~22

1
[ 144850-70-4 ]
[ 18706-21-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With PPA at 170℃; for 2h;

Reference： [1]Huang, Wei-Yuan; Liu, Yan-Song; Lu, Long [Journal of Fluorine Chemistry, 1994, vol. 66, # 2, p. 209 - 214]

2
[ CAS Unavailable ]
[ 18706-21-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 65 percent / Et₃N / acetonitrile / 6 h / 70 °C 2: 80 percent / polyphosphoric acid / 2 h / 170 °C

Reference： [1]Huang, Wei-Yuan; Liu, Yan-Song; Lu, Long [Journal of Fluorine Chemistry, 1994, vol. 66, # 2, p. 209 - 214]

3
[ 18706-21-3 ]
[ 1021528-65-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium hydroxide / acetone / 1 h / 10 °C / pH 7.5 / Inert atmosphere 2: phosphorous; iodine; acetic acid / acetic acid / 10 h / 10 - 20 °C / Inert atmosphere

Reference： [1]Meshram, H. M.; Chennakesava Reddy, B.; Aravind Kumar, D.; Kalyan, M.; Ramesh, P.; Kavitha, P.; Venkateswara Rao, J. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 9, p. 1411 - 1416,6]

4
[ 18706-21-3 ]
[ 1422372-80-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: sodium hydroxide / acetone / 1 h / 10 °C / pH 7.5 / Inert atmosphere 2: phosphorous; iodine; acetic acid / acetic acid / 10 h / 10 - 20 °C / Inert atmosphere 3: N-benzyl-trimethylammonium hydroxide / 2 h / 70 °C / Inert atmosphere

Reference： [1]Meshram, H. M.; Chennakesava Reddy, B.; Aravind Kumar, D.; Kalyan, M.; Ramesh, P.; Kavitha, P.; Venkateswara Rao, J. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 9, p. 1411 - 1416,6]

5
[ 98-59-9 ]
[ 18706-21-3 ]
[ 1021528-48-2 ]

Yield	Reaction Conditions	Operation in experiment
91%	With sodium hydroxide In acetone at 10℃; for 1h; Inert atmosphere;

Reference： [1]Meshram, H. M.; Chennakesava Reddy, B.; Aravind Kumar, D.; Kalyan, M.; Ramesh, P.; Kavitha, P.; Venkateswara Rao, J. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 9, p. 1411 - 1416,6]

6
[ CAS Unavailable ]
[ CAS Unavailable ]
[ 18706-21-3 ]

Yield	Reaction Conditions	Operation in experiment
82.44%	With PPA at 130℃; for 2h;	4A Synthesis of 6-chloro-2-(trifluoromethyl)quinolin-4-ol The mixture of 4-chloroaniline (10 g, 78.39 mmol, 1 eq) and ethyl 4,4,4-trifluoro-3-oxo- butanoate (17.32 g, 94.06 mmol, 13.74 mL, 1.2 eq) in PPA (100 mL) was stirred at 130 °C for 2 h. The reaction mixture was poured into water (500 mL) slowly. The white precipitate was filtered to give 6-chloro-2-(trifluoromethyl)quinolin-4-ol (16 g, 64.62 mmol, 82.44% yield). 1H NMR (400 MHz, DMSO-d6) δ = 13.37 - 11.29 (br s, 1H), 8.15 (br s, 1H), 8.01 (br d, J = 5.0 Hz, 1H), 7.84 (dd, J = 2.1, 9.0 Hz, 1H), 7.32 - 6.94 (s, 1H).
82.44%	With PPA at 130℃; for 2h;	4A Synthesis of 6-chloro-2-(trifluoromethyl)quinolin-4-ol The mixture of 4-chloroaniline (10 g, 78.39 mmol, 1 eq) and ethyl 4,4,4-trifluoro-3-oxo- butanoate (17.32 g, 94.06 mmol, 13.74 mL, 1.2 eq) in PPA (100 mL) was stirred at 130 °C for 2 h. The reaction mixture was poured into water (500 mL) slowly. The white precipitate was filtered to give 6-chloro-2-(trifluoromethyl)quinolin-4-ol (16 g, 64.62 mmol, 82.44% yield). 1H NMR (400 MHz, DMSO-d6) δ = 13.37 - 11.29 (br s, 1H), 8.15 (br s, 1H), 8.01 (br d, J = 5.0 Hz, 1H), 7.84 (dd, J = 2.1, 9.0 Hz, 1H), 7.32 - 6.94 (s, 1H).
75%	With polyphosphoric acid at 20 - 120℃; for 2h; Inert atmosphere;

With PPA at 150℃;

Reference： [1]Current Patent Assignee: ESCIENT PHARMACEUTICALS - WO2022/87083, 2022, A1 Location in patent: Page/Page column 132
[2]Current Patent Assignee: ESCIENT PHARMACEUTICALS - WO2022/87083, 2022, A1 Location in patent: Page/Page column 132
[3]Meshram, H. M.; Chennakesava Reddy, B.; Aravind Kumar, D.; Kalyan, M.; Ramesh, P.; Kavitha, P.; Venkateswara Rao, J. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 9, p. 1411 - 1416,6]
[4]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

7
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 120 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

8
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 120 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

9
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 120 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

10
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

11
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

12
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C 3: thionyl chloride / dichloromethane / Reflux

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

13
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C 3: thionyl chloride / dichloromethane / Reflux

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

14
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C 3: thionyl chloride / dichloromethane / Reflux 4: 110 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

15
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C 3: thionyl chloride / dichloromethane / Reflux 4: 110 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

16
[ 18706-21-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: acetone / 20 °C / Alkaline conditions 2: 90 - 110 °C 3: thionyl chloride / dichloromethane / Reflux 4: sodium azide / N,N-dimethyl-formamide / 130 °C

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

17
[ 18706-21-3 ]
[ 74-88-4 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	In acetone at 20℃; Alkaline conditions;

Reference： [1]da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Araújo, Adriele da Silva; Lourenço, Maria Cristina Silva; de Souza, Marcus Vinícius Nora [European Journal of Pharmaceutical Sciences, 2021, vol. 157]

Yield	Reaction Conditions	Operation in experiment
	With polyphosphoric acid at 100 - 110℃; for 4h; Inert atmosphere;	25.1 (1) Synthesis of intermediate M3a General procedure: Take 22.0 g (64.9 mmol) of polyphosphoric acid in a 250 mL reaction flask, add 2.0 g (16.2 mmol) of p-anisidine, and replace the argon gas.Slowly inject 2.4 mL (16.3 mmol) of ethyl trifluoroacetoacetate with stirring at 100°C. After the injection, heat up to 110°C and stir for 4 hours. The reaction is complete. Pour the reaction system into ice water and stir quickly. A large amount of precipitation can be seen. Filter with suction. , The filter cake was dried under reduced pressure to obtain 3.08 g of compound M1a, yield: 78%. Take 2.00g (8.22mmol) of compound M1a, add 50mL of glacial acetic acid to dissolve it, replace the argon gas, slowly inject 0.75mL (9.87mmol) of concentrated nitric acid at 0, and finish the injection. After stirring at 40 for 11h, the reaction is complete and the reaction is completely visible. A large amount of solids precipitated in the system, filtered with suction, washed with water to neutrality, and dried to obtain 1.61 g of compound M2a, with a yield of 67.9%. Take 300 mg (1.0 mmol) of compound M2a, add 4 mL of DMF, replace the argon, slowly inject 285 μL (3.12 mmol) of phosphorus oxychloride, stir at 100°C for 2 hours, after the reaction is complete, disperse the reactant into ethyl acetate and water, extract, and organic layer It was washed twice with water, dried over anhydrous magnesium sulfate, and the solvent was recovered under reduced pressure. The residue was purified by silica gel column chromatography to obtain 298.6 mg of compound M3a, yield: 93.5%.

19
6-chloro-2-(trifluoromethyl)quinolin-4-ol [ No CAS ]
[ 18706-33-7 ]

Yield	Reaction Conditions	Operation in experiment
98.88%	With trichlorophosphate at 20 - 90℃; for 2h; Inert atmosphere;	4A Synthesis of 4,6-dichloro-2-(trifluoromethyl)quinoline To a mixture of 6-chloro-2-(trifluoromethyl)quinolin-4-ol (16 g, 64.62 mmol, 1 eq) was added POCl3 (188.26 g, 1.23 mol, 114.10 mL, 19 eq) in portions at 20 °C under N2. The mixture was stirred at 90 °C for 2 hours. The reaction mixture was concentrated. The residue was poured into water (500 mL) dropwise then extracted with EtOAc (3x100 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give 4,6-dichloro-2-(trifluoromethyl)quinoline (17 g, 63.90 mmol, 98.88% yield). It was used as is in the next step. 1H NMR (400 MHz, DMSO-d6) δ = 8.34 (s, 1H), 8.28 (d, J = 2.2 Hz, 1H), 8.25 (d, J = 9.0 Hz, 1H), 8.03 (dd, J = 2.3, 9.0 Hz, 1H).
98.88%	With trichlorophosphate at 20 - 90℃; for 2h; Inert atmosphere;	4A Synthesis of 4,6-dichloro-2-(trifluoromethyl)quinoline To a mixture of 6-chloro-2-(trifluoromethyl)quinolin-4-ol (16 g, 64.62 mmol, 1 eq) was added POCl3 (188.26 g, 1.23 mol, 114.10 mL, 19 eq) in portions at 20 °C under N2. The mixture was stirred at 90 °C for 2 hours. The reaction mixture was concentrated. The residue was poured into water (500 mL) dropwise then extracted with EtOAc (3x100 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give 4,6-dichloro-2-(trifluoromethyl)quinoline (17 g, 63.90 mmol, 98.88% yield). It was used as is in the next step. 1H NMR (400 MHz, DMSO-d6) δ = 8.34 (s, 1H), 8.28 (d, J = 2.2 Hz, 1H), 8.25 (d, J = 9.0 Hz, 1H), 8.03 (dd, J = 2.3, 9.0 Hz, 1H).

Reference： [1]Current Patent Assignee: ESCIENT PHARMACEUTICALS - WO2022/87083, 2022, A1 Location in patent: Page/Page column 132; 133
[2]Current Patent Assignee: ESCIENT PHARMACEUTICALS - WO2022/87083, 2022, A1 Location in patent: Page/Page column 132; 133

20
[ 18706-21-3 ]
[ 2768213-12-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: trichlorophosphate / 2 h / 20 - 90 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 - 130 °C

Reference： [1]Current Patent Assignee: ESCIENT PHARMACEUTICALS - WO2022/87083, 2022, A1

21
[ 886009-75-2 ]
[ 18706-21-3 ]
[ 2820148-11-4 ]

Yield	Reaction Conditions	Operation in experiment
80%	With potassium carbonate In N,N-dimethyl-formamide for 18h; Inert atmosphere;

Reference： [1]Borsoi, Ana Flávia; Alice, Laura Manzoli; Sperotto, Nathalia; Ramos, Alessandro Silva; Abbadi, Bruno Lopes; Macchi Hopf, Fernanda Souza; Silva Dadda, Adilio Da; Rambo, Raoní S.; Madeira Silva, Rodrigo Braccini; Paz, Josiane Delgado; Pissinate, Kenia; Muniz, Mauro Neves; Neves, Christiano Ev; Galina, Luiza; González, Laura Calle; Perelló, Marcia Alberton; De Matos Czeczot, Alexia; Leyser, Mariana; De Oliveira, Sílvia Dias; De Araújo Lock, Graziela; De Araújo, Bibiana Verlindo; Costa, Teresa Dalla; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo [ACS Medicinal Chemistry Letters, 2022, vol. 13, # 8, p. 1337 - 1344]

22
[ 400-36-2 ]
[ CAS Unavailable ]
[ 18706-21-3 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: trifluoroacetylacetic acid; 4-chloro-aniline With magnesium(II) sulfate; glacial acetic acid In ethanol at 80℃; for 16h; Stage #2: at 230 - 250℃; for 0.25h;

Reference： [1]Borsoi, Ana Flávia; Alice, Laura Manzoli; Sperotto, Nathalia; Ramos, Alessandro Silva; Abbadi, Bruno Lopes; Macchi Hopf, Fernanda Souza; Silva Dadda, Adilio Da; Rambo, Raoní S.; Madeira Silva, Rodrigo Braccini; Paz, Josiane Delgado; Pissinate, Kenia; Muniz, Mauro Neves; Neves, Christiano Ev; Galina, Luiza; González, Laura Calle; Perelló, Marcia Alberton; De Matos Czeczot, Alexia; Leyser, Mariana; De Oliveira, Sílvia Dias; De Araújo Lock, Graziela; De Araújo, Bibiana Verlindo; Costa, Teresa Dalla; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo [ACS Medicinal Chemistry Letters, 2022, vol. 13, # 8, p. 1337 - 1344]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
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Code	Phrase
P301	IF SWALLOWED:
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P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere