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Chemical Structure| 18718-83-7 Chemical Structure| 18718-83-7

Structure of 18718-83-7

Chemical Structure| 18718-83-7

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Product Details of [ 18718-83-7 ]

CAS No. :18718-83-7
Formula : C11H10ClNO
M.W : 207.66
SMILES Code : CC1=C(CCl)C(C2=CC=CC=C2)=NO1

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Application In Synthesis of [ 18718-83-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18718-83-7 ]

[ 18718-83-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 53137-27-2 ]
  • [ 18718-83-7 ]
  • [ 1254969-88-4 ]
YieldReaction ConditionsOperation in experiment
60% Example 14-Methyl-2- [2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl] -thiazole-5-carboxylic acid iso- propylamidea) 2- [2-(5-Methyl-3 -phenyl- isoxazol-4-yl)-ethyl] -thiazole-5-carboxylic acidTo a stirred solution of <strong>[53137-27-2]2,4-dimethyl-thiazole-5-carboxylic acid</strong> (250 mg, 1.59 mmol) inTHF (16 mL) at -78C and under argon was added LDA (1.6 mL of a 2M solution in THF, 3.2 mmol) dropwise. After 1.5 h a solution of 4-chloromethyl-5-methyl-3-phenyl-isoxazole (330 mg, 1.59 mmol) in THF (4 mL) was added dropwise. After 1 h the reaction mixture was quenched with HCl (IN, 10 mL) then warmed to room temperature and extracted with ethyl acetate. The combined extracts were dried, filtered and concentrated. Purification by chromatography (silica, 0 to 10% methanol in dichloromethane) gave the title compound (315 mg, 60%) as a light yellow gum. MS: m/e = 329.1 [M+H]+.
  • 2
  • [ 40004-69-1 ]
  • [ 18718-83-7 ]
  • [ 1254969-89-5 ]
YieldReaction ConditionsOperation in experiment
61% ) 2- [2-(5-Methyl-3 -phenyl- isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acidTo a stirred solution of <strong>[40004-69-1]2-methyl-thiazole-5-carboxylic acid</strong> (100 mg, 0.7 mmol) in THF (5 mL) at -72°C and under argon was added LDA (0.7 mL of a 2M solution in THF, 1.40 mmol) dropwise. After 1.5 h a solution of 4-chloromethyl-5-methyl-3 -phenyl- isoxazo Ie (145 mg, 0.7 mmol) in THF (5 mL) was added dropwise. After 1 h the reaction mixture was quenched with HCl (IN, 10 mL) then warmed to room temperature and extracted with ethyl acetate. The combined extracts were dried, filtered and concentrated then triturated with diisopropyl ether to give the title compound (135 mg, 61percent) as a light brown solid which was used directly in the next reaction.
 

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