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Chemical Structure| 187217-99-8 Chemical Structure| 187217-99-8

Structure of 187217-99-8

Chemical Structure| 187217-99-8

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Product Details of [ 187217-99-8 ]

CAS No. :187217-99-8
Formula : C7H13F3N2
M.W : 182.19
SMILES Code : NC1CCN(CC(F)(F)F)CC1
MDL No. :MFCD09040660

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Application In Synthesis of [ 187217-99-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 187217-99-8 ]

[ 187217-99-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 187217-99-8 ]
  • [ 505082-91-7 ]
  • [ 1033844-11-9 ]
YieldReaction ConditionsOperation in experiment
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20℃; for 1.0h; To a vial was added <strong>[505082-91-7]6-(2-fluorophenyl)nicotinic acid</strong> (100 mg, 0.46 mmol), 1-(2,2,2-trifluoroethyl)piperidin-4-amine (83.8 mg, 0.46 mmol), EDAC (97.1 mg, 0.51 mmol), HOBT (62.2 mg, 0.46 mmol), DMA (2 mL) and NMM (0.127 mL, 1.15 mmol). The reaction was stirred for 1 hour at room temperature and then diluted with EtOAc (0.2 mL) followed by H2O (4 mL). The resulting solids were washed in H2O and collected by filtration. 1 H NMR (400 MHz, DMSO-d6) ppm 9.11 (1 H, d, J=1.9 Hz), 8.52 (1 H, d, J=7.5 Hz), 8.28 (1 H, dd, J=8.3, 2.3 Hz), 7.94-8.05 (1 H, m), 7.90 (1 H, dd, J=8.4, 1.5 Hz), 7.50-7.58 (1 H, m), 3.72-3.89 (1 H, m), 3.19 (2 H, q, J=10.3 Hz), 2.95 (2 H, d, J=11.9 Hz), 2.40-2.48 (2 H, m) 1.82 (2 H, d, J=13.1 Hz), 1.52-1.67 (2 H, m).
 

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