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Chemical Structure| 187756-76-9 Chemical Structure| 187756-76-9

Structure of 187756-76-9

Chemical Structure| 187756-76-9

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Product Details of [ 187756-76-9 ]

CAS No. :187756-76-9
Formula : C10H23BrOSi
M.W : 267.28
SMILES Code : C[Si](C(C)(C)C)(OC[C@@H](C)CBr)C

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Application In Synthesis of [ 187756-76-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 187756-76-9 ]

[ 187756-76-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1776-37-0 ]
  • [ 187756-76-9 ]
  • (S)-1-(3-((tert-butyldimethylsilyl)oxy)-2-methylpropyl)-5-methyl-1H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.12 g With caesium carbonate; In N,N-dimethyl-formamide; at 50℃; for 15h; [0227] 5 -methyl- lH-indazole (760 mg), ((R)-3-bromo-2-methylpropoxy)(tert- butyl)dimethylsilane (1.59 g) and CsC03 were stirred in DMF at 50 °C for 15 h and thereafter the suspension was cooled to rt, water added and the mixture extracted with ethyl acetate and the combined organic layers washed with water and brine, dried over Na2S04, concentrated and purified by flash column chromatography (Si02: petroleum ether/ethyl acetate 20: 1), to give a colorless oil of (S)-l -(3 -((tert-butyldimethylsilyl)oxy)-2-methylpropyl)-5 -methyl- lH-indazole (l -12g).
 

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