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[ CAS No. 188707-99-5 ] {[proInfo.proName]}

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Chemical Structure| 188707-99-5
Chemical Structure| 188707-99-5
Structure of 188707-99-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 188707-99-5 ]

CAS No. :188707-99-5 MDL No. :MFCD10699651
Formula : C6H7ClN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 142.59 Pubchem ID :-
Synonyms :

Safety of [ 188707-99-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 188707-99-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 188707-99-5 ]

[ 188707-99-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 188707-99-5 ]
  • [ 1193-85-7 ]
YieldReaction ConditionsOperation in experiment
With ammonia
  • 2
  • [ 79762-54-2 ]
  • [ 188707-99-5 ]
  • 6-bromo-1-(4-ethylpyrimidin-2-yl)-1H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% To a solution of <strong>[79762-54-2]6-bromo-1H-indazole</strong> (2.5 g, 12.7 mmol, 1.0 eq) in dry DMF (10 mL) was slowly added NaH (560 mg, 14.0 mmol, 1.1 eq) at rt. After stirring at ft for 10 mm, 2-chloro-4-ethylpyrimidine (2.0 g, 14.0 mmol, 1.1 eq) was added to the mixture. Then the mixturewas stirred at 130 C for 4 h under N2 atmosphere. After cooling down to rt, the mixture wasdiluted with H20 (50 mL) and stirred at ft for 10 mm. The precipitate was collected by filtration and was purified by silica gel chromatography (PE/EA = 3/1) to give 6-bromo-1-(4-ethylpyrimidin-2-yl)-1H-indazole as a yellow solid. 3.5 g, Y: 91%. ESI-MS (M+H): 303.1. ?H NMR (400 MHz, CDC13) (5: 9.06 (s, 1H), 8.69 (d, J = 5.2 Hz, 1H), 8.26 (s, 1H), 7.64 (d, J = 8.4Hz, 1H), 7.42 (d, J= 8.0 Hz, 1H), 7.07 (d, J= 5.2 Hz, 1H), 2.96 (q, J= 7.6 Hz, 2H), 1.43 (t, J= 7.6 Hz, 3H).
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