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CAS No. : | 188707-99-5 | MDL No. : | MFCD10699651 |
Formula : | C6H7ClN2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 142.59 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
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With ammonia |
Yield | Reaction Conditions | Operation in experiment |
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91% | To a solution of <strong>[79762-54-2]6-bromo-1H-indazole</strong> (2.5 g, 12.7 mmol, 1.0 eq) in dry DMF (10 mL) was slowly added NaH (560 mg, 14.0 mmol, 1.1 eq) at rt. After stirring at ft for 10 mm, 2-chloro-4-ethylpyrimidine (2.0 g, 14.0 mmol, 1.1 eq) was added to the mixture. Then the mixturewas stirred at 130 C for 4 h under N2 atmosphere. After cooling down to rt, the mixture wasdiluted with H20 (50 mL) and stirred at ft for 10 mm. The precipitate was collected by filtration and was purified by silica gel chromatography (PE/EA = 3/1) to give 6-bromo-1-(4-ethylpyrimidin-2-yl)-1H-indazole as a yellow solid. 3.5 g, Y: 91%. ESI-MS (M+H): 303.1. ?H NMR (400 MHz, CDC13) (5: 9.06 (s, 1H), 8.69 (d, J = 5.2 Hz, 1H), 8.26 (s, 1H), 7.64 (d, J = 8.4Hz, 1H), 7.42 (d, J= 8.0 Hz, 1H), 7.07 (d, J= 5.2 Hz, 1H), 2.96 (q, J= 7.6 Hz, 2H), 1.43 (t, J= 7.6 Hz, 3H). |