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Chemical Structure| 18977-45-2 Chemical Structure| 18977-45-2

Structure of 18977-45-2

Chemical Structure| 18977-45-2

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Product Details of [ 18977-45-2 ]

CAS No. :18977-45-2
Formula : C5H11N
M.W : 85.15
SMILES Code : CNCC1CC1
MDL No. :MFCD11150443
InChI Key :BFPMCZWKUSUMKE-UHFFFAOYSA-N
Pubchem ID :12919209

Safety of [ 18977-45-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H314
Precautionary Statements:P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501
Class:3(8)
UN#:2733
Packing Group:

Application In Synthesis of [ 18977-45-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 18977-45-2 ]

[ 18977-45-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18977-45-2 ]
  • [ 161957-56-8 ]
  • 3-bromo-N-cyclopropylmethyl-2-fluoro-N-methyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 18h; 47a) 3-Bromo-N-cyclopropylmethyl-2-fluoro-N-methyl-benzamide A solution of 3-bromo-2-fluoro-benzoic acid (0.50 g, 2.28 mmol), HATU (1 .30 g, 3.42 mmol), cyclopropylmethyl-methylamine (0.42 g, 3.42 mmol) and DIPEA (0.89 g, 6.85 mmol) in DMF (9 mL) was stirred for 18 h. The mixture was partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc and the combined organic phases washed with water (x 2) and brine before drying (MgS04), filtering, and concentrating to give the product (0.708g, quantative), used without further purification. LC-MS m/z 573 (2M + H) +, 1 .32 (ret. time), basic method.
 

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