[ CAS No. 1904-24-1 ] {[proInfo.proName]}

Name: 1904-24-1|3-Amino-5-ethylpyrazole|97%
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Quality Control of [ 1904-24-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1904-24-1 ]

SDS Specification

Alternatived Products of [ 1904-24-1 ]

Product Details of [ 1904-24-1 ]

CAS No. :	1904-24-1	MDL No. :	MFCD08060982
Formula :	C₅H₉N₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	AXDGPQLEVYSXNL-UHFFFAOYSA-N
M.W :	111.15	Pubchem ID :	21991095
Synonyms :

Safety of [ 1904-24-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1904-24-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1904-24-1 ]
Downstream synthetic route of [ 1904-24-1 ]

[ 1904-24-1 ] Synthesis Path-Upstream 1~2

1
[ 33279-01-5 ]
[ 1904-24-1 ]

Yield	Reaction Conditions	Operation in experiment
78%	With hydrazine hydrate In ethanol for 12 h; Reflux	To a stirred solution of 3-oxopentanenitrile (XXXV; 2g; 21 mmol) in ethanol (60 mL) was added hydrazine hydrate (1.3 mL; 41 mmol). The reaction mixture was heated to a reflux for12 hours. The reaction mixture was cooled and concentrated under reduced pressure. The crude mixture was purified by column chromatography using 8percent MeOH-DCM to obtain 5-ethyl-1H- pyrazol-3-amine as a brown sticky solid (XXXVI; 1.8 g; 78percent yield). ‘H NMR (400 MHz,DMSO-d6): ö 11.0 (bs, 1H), 5.17 (s, 1H), 4.5 (bs, 2H), 2.4 (m, 2H), 1.1 (m, 3H). MS (M+1):111.93.
51%	With hydrazine In ethanol at 70℃; for 12 h;	A mixture of a portion (0.6 g) of the material so obtained, hydrazine hydrate (0.28 ml) and ethanol (45 ml) was heated at 70°C for 12 hours. The solvent was evaporated and the residue was purified by column chromatography on silica using a 19:1 mixture of methylene chloride and methanol as eluent. There was thus obtained the required starting material in 51percent yield; ¹H NMR: (DMSOd₆) 1.04 (t, 3H)₅ 2.41 (q, 2H), 4.4 (br s, 2H).

Reference： [1] Patent: WO2015/97122, 2015, A1, . Location in patent: Page/Page column 92
[2] Patent: WO2007/99326, 2007, A1, . Location in patent: Page/Page column 114

2
[ 554-12-1 ]
[ 75-05-8 ]
[ 1904-24-1 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1998, vol. 46, # 1, p. 69 - 78

[ 1904-24-1 ] Synthesis Path-Downstream 1~61

1
[ 2208-07-3 ]
[ 1904-24-1 ]
N-(5-ethyl-1H-pyrazol-3-yl)acetamidine hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		(A) In the same manner as described in the step (A) of Reference Example 19, 9.97 g of N-(5-ethyl-1H-pyrazol-3-yl)acetamidine hydrochloride was obtained from 12.9 g of <strong>[1904-24-1]3-amino-5-ethyl-1H-pyrazole</strong> and 16.3 g of ethyl acetimidate hydrochloride.

Reference： [1]Chemical and Pharmaceutical Bulletin,1998,vol. 46,p. 69 - 78
[2]Patent: US5475114,1995,A

2
[ 40546-35-8 ]
[ 1904-24-1 ]
N-(5-ethyl-1H-pyrazol-3-yl)propionamidine hydrochloride [ No CAS ]