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Chemical Structure| 191284-80-7 Chemical Structure| 191284-80-7

Structure of 191284-80-7

Chemical Structure| 191284-80-7

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Product Details of [ 191284-80-7 ]

CAS No. :191284-80-7
Formula : C13H13NO
M.W : 199.25
SMILES Code : NC1=CC=C(OC2=CC=CC=C2)C(C)=C1

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Application In Synthesis of [ 191284-80-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 191284-80-7 ]

[ 191284-80-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3973-08-8 ]
  • [ 191284-80-7 ]
  • 1-(3-methyl-4-phenoxyphenyl)-3-(1,3-thiazol-4-yl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% A solution of 1 ,3-<strong>[3973-08-8]Thiazole-4-carboxylic acid</strong> (0.50 g, 0.0038 mol) in toluene (5.0 ml) was stirred and cooled to 0C and TEA (1.63 ml, 0.0116 mol) was added drop wise. To the resulting mixture diphenyl phosphoryl azide (DPPA, 1.17 g, 0.0042 mol) was added dropwise and stirred at 0C for 1 h. 3-methyl-4-phenoxy-aniline (0.50 g, 0.0025 mol) in toluene was added dropwise and resulting reaction mixture was stirred at 110C for 16 h. The solvent was evaporated and the reaction mixture was quenched with water (40 ml) and extracted with EtOAc (3 x 50 ml). The combined organic layer was washed with brine (40 ml) and dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by Combi-flash chromatography using 30% ethyl acetate in hexanes as an eluent to yield 0.400 g (49% yield) the title compound. 1H NMR (400 MHz, DMSO-d6) d ppm 9.47 (s, 1 H), 8.95 (d, J = 2.2 Hz, 1 H), 8.78 (s, 1 H), 7.43 (d, J = 2.6 Hz, 1 H), 7.38 - 7.27 (m, 4H), 7.04 (t, J = 7.4 Hz, 1 H), 6.90 (d, J = 8.8 Hz, 1 H), 6.89 - 6.79 (m, 2H), 2.12 (s, 3H). MS(ESI+) m/z 326 (M+H)+
 

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