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[ CAS No. 19178-25-7 ]

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2D
Chemical Structure| 19178-25-7
Chemical Structure| 19178-25-7
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Product Details of [ 19178-25-7 ]

CAS No. :19178-25-7MDL No. :MFCD09999183
Formula : C7H5N3O Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :147.13Pubchem ID :135567106
Synonyms :

Computed Properties of [ 19178-25-7 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 19178-25-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19178-25-7 ]

  • Upstream synthesis route of [ 19178-25-7 ]
  • Downstream synthetic route of [ 19178-25-7 ]

[ 19178-25-7 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 7579-20-6 ]
  • [ 19178-25-7 ]
Reference: [1] Patent: US5654307, 1997, A
[2] Patent: US5034393, 1991, A
[3] Patent: WO2013/12915, 2013, A1
  • 2
  • [ 3473-63-0 ]
  • [ 7579-20-6 ]
  • [ 19178-25-7 ]
YieldReaction ConditionsOperation in experiment
35% at 160℃; for 0.50 h; Microwave irradiation A Biotage microwave vial was charged with 3-aminoisonicotinic acid (691 mg, 5.0 mmol), formamidine acetate (573 mg, 5.5 mmol), and ethanol (10 mL). The reaction mixture was heated in the microwave at 160 °C for 30 min, diluted with H20 (20 mL), and cooled to 0 °C. The suspension was filtered and the solids were washed with cold H20 (10 mL) to provide quinazoline A2 (259 mg, 35percent) as a white solid: LC-MS (>98percent) m/z = 148.0[M+H], Rt= 0.604.
Reference: [1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1370 - 1387
[2] Patent: WO2014/179237, 2014, A1. Location in patent: Paragraph 00491
  • 3
  • [ 64188-97-2 ]
  • [ 122-51-0 ]
  • [ 19178-25-7 ]
Reference: [1] Patent: WO2013/12915, 2013, A1. Location in patent: Paragraph 00677
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