[ CAS No. 192642-85-6 ] {[proInfo.proName]}

Name: 192642-85-6|2-(5-Bromopyridin-2-yl)acetic acid|95% Titration by NaOH
Brand: Ambeed
SKU: A241033
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Quality Control of [ 192642-85-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 192642-85-6 ]

Product Details of [ 192642-85-6 ]

CAS No. :	192642-85-6	MDL No. :	MFCD09999983
Formula :	C₇H₆BrNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ATKULCGQSLCGEK-UHFFFAOYSA-N
M.W :	216.03	Pubchem ID :	46238459
Synonyms :

Calculated chemistry of [ 192642-85-6 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.14
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	43.48
TPSA :	50.19 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.88 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.3
Log Po/w (XLOGP3) :	1.04
Log Po/w (WLOGP) :	1.47
Log Po/w (MLOGP) :	0.82
Log Po/w (SILICOS-IT) :	1.72
Consensus Log Po/w :	1.27

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-2.11
Solubility :	1.69 mg/ml ; 0.00783 mol/l
Class :	Soluble
Log S (Ali) :	-1.68
Solubility :	4.47 mg/ml ; 0.0207 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.66
Solubility :	0.469 mg/ml ; 0.00217 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.65

Safety of [ 192642-85-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302+H312+H332-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 192642-85-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 192642-85-6 ]
Downstream synthetic route of [ 192642-85-6 ]

[ 192642-85-6 ] Synthesis Path-Upstream 1~6

1
[ 1215098-80-8 ]
[ 192642-85-6 ]

Yield	Reaction Conditions	Operation in experiment
80%	Stage #1: With water; sodium hydroxide In methanol at 20℃; for 3 h; Stage #2: With hydrogenchloride In water	Example 40 5-(Bromo-pyridin-2-yl)-acetic acidTo a solution of 2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (16.6 g, 52.5 mmol) in MeOH (200 mL) was added aq. NaOH (2N, 105 mL, 210 mmol). The solution was stirred at room temperature for 3 h, then concentrated in vacuo. The residue was dissolved in water and neutralized with 2N HCl to pH 3-4. Then the solid was filtered and washed with water, ether, dried to give a white solid product without further purification (9.0 g, 80percent). MS: calc'd 215 (MH+), exp 215 (MH+).
70%	With sodium hydroxide In methanol; water at 20℃; for 3 h;	To a solution of diethyl 2-(5-bromopyridin-2-yl)malonate 166 (2.1 g, 6.6 mmol) in MeOH (30 mL) was added 2 M NaOH aqueous solution (14 mL, 28 mmol). The resulting mixture was stirred at room temperature for 3 hours. The solution was concentrated under reduced pressure and the residue was dissolved in water (20 mL). The pH of the solution was adjusted to 3-4 by addition of 6 M HCI. The white precipitate formed was collected by filtration, washed with water and dried at 50 °C to give the title compound as a white solid (1 .0 g, 70percent). LCMS-C: RT 0.78 min; m/z 216.0 [M+H]⁺.

Reference： [1] Patent: US2010/69328, 2010, A1, . Location in patent: Page/Page column 36
[2] Patent: WO2016/34673, 2016, A1, . Location in patent: Page/Page column 100
[3] Patent: WO2014/53967, 2014, A1, . Location in patent: Page/Page column 160; 161

2
[ 192642-83-4 ]
[ 192642-85-6 ]

Reference： [1] Tetrahedron, 1997, vol. 53, # 24, p. 8257 - 8268
[2] Patent: WO2011/45703, 2011, A2, . Location in patent: Page/Page column 34

3
[ 2402-97-3 ]
[ 192642-85-6 ]

Reference： [1] Tetrahedron, 1997, vol. 53, # 24, p. 8257 - 8268
[2] Patent: WO2011/45703, 2011, A2,

4
[ 223463-13-6 ]
[ 192642-85-6 ]

Reference： [1] Patent: WO2014/53967, 2014, A1,
[2] Patent: WO2016/34673, 2016, A1,

5
[ 626-55-1 ]
[ 192642-85-6 ]

Reference： [1] Patent: WO2011/45703, 2011, A2,

6
[ 67-56-1 ]
[ 192642-85-6 ]
[ 917023-06-4 ]

Yield	Reaction Conditions	Operation in experiment
90%	at 0 - 20℃; for 3 h;	Example 41 ; (5-Bromo-pyridin-2-yl)-acetic acid methyl esterTo a solution of 5-(Bromo-pyridin-2-yl)-acetic acid (9 g, 41.7 mmol) in MeOH (80 mL), SOCl₂(10 g, 83.4 mmol) was added at 0 degrees Celsius, then the mixture stirred at room temperature for 3 h. After cooling, the solution was evaporated to dryness under reduced pressure, then EtOAc was added and the mixture was washed with aq. NaHCO₃, the organic layer was dried with MgSO₄, and evaporated to give the compound as an oil (8.6 g, 90percent). MS: calc'd 229 (MH+), exp 229 (MH+).

Reference： [1] Patent: US2010/69328, 2010, A1, . Location in patent: Page/Page column 36

[ 192642-85-6 ] Synthesis Path-Downstream 1~40

1
[ 192642-83-4 ]
[ 192642-85-6 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In water; for 2h;Reflux;	Preparation of 5:2-(5-Bromopyridin-2-yl)acetic acidA solution of 5-(5-bromopyridin-2(1 H)-ylidene)-2,2-dimethyl-1 ,3-dioxane-4,6- dione (3) (40.0 g, 133.3 mmol) in HCI (30%, 400 mL) was heated gently to reflux, and was refluxed for 2h. The solvent was removed in vacuo and the residue (29.75 g) was used in the next step without further purification. 1 H-NMR (CDCI3, 300 MHz): delta 3.79 (s,2H, CH2), 7.41 (d, 1 H, ArH), 8.08 (dd, 1 H, ArH), 8.66 (d, 1 H, ArH).

Reference： [1]Tetrahedron,1997,vol. 53,p. 8257 - 8268
[2]Patent: WO2011/45703,2011,A2 .Location in patent: Page/Page column 34

2
[ 2402-97-3 ]
[ 192642-85-6 ]

Reference： [1]Tetrahedron,1997,vol. 53,p. 8257 - 8268
[2]Patent: WO2011/45703,2011,A2

3
[ 74-89-5 ]
[ 192642-85-6 ]
[ 1160789-82-1 ]

Yield	Reaction Conditions	Operation in experiment
27%		To a suspension of delta-bromo-pyridin^-yl-acetic acid (0.87 g, 4.0 mmol) in THF (12 mL) was added HOBt (0.74 g, 4.8 mmol) and EDCI. HCI (0.85 g, 4.4 mmol) and stirred the resulting reaction mixture for 15-20min at room temperature followed by drop-wise addition of methyl amine (2.0 M in THF, 4.05 mL, 8.0 mmol). The resulting mixture was then continued to stir for 6-7 h at room temperature. After completion of reaction, water was added and extracted with ethyl acetate. The crude residue was purified over silica (60-120 M) using dichloromethane:methanol (97.5:2.5) to obtain the pale-yellow solid compound (0.25 g, 27%). 1H NMR (DMSO-d6, 400 MHz): delta 2.58 (d, J= 4.8 Hz, 3H), 3.57 (s, 2H)1 7.33 (d, J= 1 H), 7.96 (d, J= 2.4 Hz & 8.4 Hz, 1 H), 8.00 (br s, 1 H) and 8.58 (d, J= 2.4 Hz, 1 H). MS: 229.11 (M+H+).

Reference： [1]Patent: WO2009/74812,2009,A1 .Location in patent: Page/Page column 15

4
[ 67-56-1 ]
[ 192642-85-6 ]
[ 917023-06-4 ]

Yield	Reaction Conditions	Operation in experiment
90%	With thionyl chloride; at 0 - 20℃; for 3h;	Example 41 ; (5-Bromo-pyridin-2-yl)-acetic acid methyl esterTo a solution of 5-(Bromo-pyridin-2-yl)-acetic acid (9 g, 41.7 mmol) in MeOH (80 mL), SOCl2 (10 g, 83.4 mmol) was added at 0 degrees Celsius, then the mixture stirred at room temperature for 3 h. After cooling, the solution was evaporated to dryness under reduced pressure, then EtOAc was added and the mixture was washed with aq. NaHCO3, the organic layer was dried with MgSO4, and evaporated to give the compound as an oil (8.6 g, 90%). MS: calc'd 229 (MH+), exp 229 (MH+).
	With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 - 45℃; for 12h;	General procedure: To a suspended solution of 2-pyridylacetic acid hydrochloride (1.0 mmol) and alcohol(1.5 mmol) in 5 mL dichloromethane was added triethylamine (2.0 mmol),1,3-dicyclohexylcarbodiimide (DCC) (1.0 mmol) and a catalytic amount of4-(dimethylamino)pyridine (DMAP) (0.05 mmol) at 25 oC. The reaction mixture wasstirred 12 h at 45 oC, the reaction mixture was filtered to remove 1,3-dicyclohexylurea.The filtrate was washed with water (3×5 mL), dried with MgSO4 and concentratedunder reduced pressure, the crude product was purified by column chromatography togive the pure sample.

Reference： [1]Patent: US2010/69328,2010,A1 .Location in patent: Page/Page column 36
[2]Journal of Organic Chemistry,2019,vol. 84,p. 1630 - 1639
[3]Synlett,2019,vol. 30,p. 863 - 867

5
[ 1215098-80-8 ]
[ 192642-85-6 ]

Yield	Reaction Conditions	Operation in experiment
80%		Example 40 5-(Bromo-pyridin-2-yl)-acetic acidTo a solution of 2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (16.6 g, 52.5 mmol) in MeOH (200 mL) was added aq. NaOH (2N, 105 mL, 210 mmol). The solution was stirred at room temperature for 3 h, then concentrated in vacuo. The residue was dissolved in water and neutralized with 2N HCl to pH 3-4. Then the solid was filtered and washed with water, ether, dried to give a white solid product without further purification (9.0 g, 80%). MS: calc'd 215 (MH+), exp 215 (MH+).
70%	With sodium hydroxide; In methanol; water; at 20℃; for 3h;	To a solution of diethyl 2-(5-bromopyridin-2-yl)malonate 166 (2.1 g, 6.6 mmol) in MeOH (30 mL) was added 2 M NaOH aqueous solution (14 mL, 28 mmol). The resulting mixture was stirred at room temperature for 3 hours. The solution was concentrated under reduced pressure and the residue was dissolved in water (20 mL). The pH of the solution was adjusted to 3-4 by addition of 6 M HCI. The white precipitate formed was collected by filtration, washed with water and dried at 50 C to give the title compound as a white solid (1 .0 g, 70%). LCMS-C: RT 0.78 min; m/z 216.0 [M+H]+.
	With water; lithium hydroxide; In tetrahydrofuran; at 60℃; for 3h;	To a solution of diethyl(5-bromopyridin-2-yl)malonate (Preparation 134, 5.28 g, 16.70 mmol) in THF (50 ml_) was added a solution of LiOH (2.10 g, 50.13 mmol) in water (12.5 ml_) and the reaction was heated to 60C for 3 hours. The reaction was cooled and acidified to pH 3-4 with 2N HCI and diluted with 20% IPA in DCM. The organic layer was collected, dried over sodium sulphate and concentrated in vacuo. The crude residue was triturated with hexane to afford the title compound. 1H NMR (400 MHz, DMSO-d6): delta ppm 3.73 (s, 2H), 7.36 (d, 1 H), 8.01 (m, 1 H), 8.61 (d, 1 H), 12.5 (s, 1 H).

Reference： [1]Patent: US2010/69328,2010,A1 .Location in patent: Page/Page column 36
[2]Patent: WO2016/34673,2016,A1 .Location in patent: Page/Page column 100
[3]Patent: WO2014/53967,2014,A1 .Location in patent: Page/Page column 160; 161

6
[ 192642-85-6 ]
[ 1206968-77-5 ]

Yield	Reaction Conditions	Operation in experiment
80%		[Example 60]tert-Butyl 4-[2-[2-(4-methanesulfonylphenoxyethyl)pyridine-5-yl]piperidine-1-carboxylate (1) 2-(5-Bromopyridin-2-yl)ethanol To a solution of <strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong> (60.0 mg, 0.278 mmol) in dry tetrahydrofuran (1.4 mL) was added dropwise borane- tetrahydrofuran complex (1.06M in tetrahydrofuran, 0.34 mL, 0.361 mmol) under N2. The mixture was stirred at room temperature for 19 hours and water(5 mL)-acetic acid (5 mL) was added slowly. The mixture was concentrated under reduced pressure, the residue was poured into saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=7/1?ethyl acetate) to give the title compound as a yellow oil (45 mg, yield 80%).1H NMR(CDCl3,400 MHz): delta= 2.98(2H, t, J=5 Hz), 3.68(1H, brs), 4.01(2H, t, J=5 Hz), 7.09(1H, d, J=8 Hz), 7.75(1H, dd, J=2 Hz, 8 Hz), 8.57(1H, d, J=2 Hz).
79%	With diborane; In tetrahydrofuran; at -78 - 20℃; for 16h;Inert atmosphere;	[00543] To a solution of Example 105a (2.16 g, 10.0 mmol) in dry THF (80 mL) was added slowly added BH3/THF (1.0 M, 30 mL) at -78C under nitrogen atmosphere. After addition, the mixture was allowed to stir from -78C to r.t. for 16 h. The reaction was quenched by saturated aqueous K2C03, extracted by EtOAc (50 mL*2), dried over Na2S04, filtered and concentrated. The residue was purified by silica gel chromatography (Petroleum Ether/EtOAc = 30/70) to give the desired product Example 105b (1.6 g, yield 79%) as colorless oil. LCMS [M+l]+ =202.0/204.0
51%	In Petroleum ether;	a. 2-(5-bromo-2-pyridyl)ethanol To a stirred solution of <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (2 g, 9.25 mmol) in THF (50 mL) was added BH3.THF (12 mL, 12.03 mmol, 1M in THF) drop wise at room temperature under nitrogen and stirred at same temperature for 24 h. The mixture was cooled to 0 C, quenched with water: acetic acid (10 mL, 1:1) and stirred at room temperature for 30 minutes. The reaction mixture was evaporated and resulting residue was diluted with EtOAc (50 mL). The organic layer was washed with saturated aqueous sodium bicarbonate solution and water, dried, filtered and evaporated. The crude compound was chromatographed on silica eluting with 40% EtOAc in petroleum ether affording a yellow liquid (950 mg, 51%). M/z = 202.0 (M+H)+.

		Preparation of 6:2-(5-Bromopyridin-2-yl)ethanolUnder N2, a solution of <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (5, 29.75 g) in THF (450 mL) was cooled to 0C. Borane THF complex (1 M in THF, 413.2 mL, 413.2 mmol) was added dropwise, keeping the reaction temperature below 5C. The mixture was allowed to warm to room temperature and stir for 4h. The mixture was cooled to 0C and saturated aqueous K2C03 solution (500 mL) and H20 (500 mL) were added slowly. The mixture was extracted with EtOAc (3x 500 mL). The combined organic layers were washed with brine (500 mL), dried over Na2S04 and filtered. The solvent was removed in vacuo and the residue was purified by column chromatography (silica,Heptane/EtOAc 3:7) yielding compound 6 (10.9 g, 53.9 mmol, 40% over 2 steps). 1 H- NMR (CDCI3, 300 MHz): delta 3.00 (t, 2H, CH2), 3.64 (bs, 1 H, OH), 4.03 (t, 2H, CH2), 7.10 (d, 1 H, ArH), 7.76 (dd, 1 H, ArH), 8.59 (d, 1 H, ArH).
1.09 g	With borane-THF; In tetrahydrofuran; at 5 - 20℃;	Commercially available <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (1.00 g, 4.6 mmol) in tetrahydrofuran (10 mL) is cooled to 5 C. and treated dropwise over 10 minutes with borane-tetrahydrofuran complex (13.9 mL, 13.9 mmol). After stirring at room temperature for 4 hours, the reaction mixture is quenched with saturated aqueous potassium carbonate (20 mL), extracted with ethyl acetate (50 mL), dried over MgSO4, filtered, the solvent removed under reduced pressure, and the crude material purified by column chromatography on silica gel eluting with a gradient of neat heptane to neat ethyl acetate to afford the title compound (1.09 g): m/z (CI) 203 [M+H].

Reference： [1]Patent: EP2311822,2011,A1 .Location in patent: Page/Page column 51
[2]Patent: WO2019/51265,2019,A1 .Location in patent: Paragraph 00543
[3]Patent: EP3628672,2020,A1
[4]Patent: WO2011/45703,2011,A2 .Location in patent: Page/Page column 34
[5]Patent: US2014/88046,2014,A1 .Location in patent: Paragraph 0111-0112

7
[ 626-55-1 ]
[ 192642-85-6 ]

Reference： [1]Patent: WO2011/45703,2011,A2

8
[ 504-29-0 ]
[ 192642-85-6 ]
[ 1204651-59-1 ]

Yield	Reaction Conditions	Operation in experiment
45%	With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20℃; for 3h;Inert atmosphere;	Under an inert atmosphere, 0.09 g (0.95 mmol) of 2-aminopyridine, 0.31 g (2.4 mmol) of diisopropylethylamine and 0.35 g (1.1 mmol) of TBTU are successively added to 0.26 g (0.95 mmol) of <strong>[192642-85-6](5-bromo-2-pyridyl)acetic acid</strong> (a synthesis of which is described in Tetrahedron, 1997, 53(24) 8257-8268 Gurnos J. et al.) dissolved in anhydrous THF (4 ml). The reaction mixture is stirred for 3 hours at room temperature. The reaction mixture is concentrated under reduced pressure, the residue is taken up in ethyl acetate (20 ml) and the organic phase thus obtained is then washed with saturated ammonium chloride solution (15 ml) and with saturated sodium hydrogen carbonate solution (15 ml), and then dried over Na2SO4, filtered and concentrated under reduced pressure. The residue is purified by flash chromatography on silica gel (eluent: dichloromethane/ethyl acetate, 1% NH4OH), with a gradient of 0% to 20% ethyl acetate, 1% NH4OH. 0.125 g of compound is obtained in the form of a white powder. Yield: 45%. Melting point: 131 C. MH+: 292-294 (tr: 6.1 min., condition 1)

Reference： [1]Patent: US2011/124643,2011,A1 .Location in patent: Page/Page column 17

9
[ 192642-85-6 ]
[ 1582262-84-7 ]

Reference： [1]Patent: US2014/88046,2014,A1

10
[ 192642-85-6 ]
[ 1582261-92-4 ]

Reference： [1]Patent: US2014/88046,2014,A1

11
[ 223463-13-6 ]
[ 192642-85-6 ]

Reference： [1]Patent: WO2014/53967,2014,A1
[2]Patent: WO2016/34673,2016,A1

12
tert-butyl (S)-2-amino-4-isopropyl-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole-5-carboxylate [ No CAS ]
[ 192642-85-6 ]
C₂₀H₂₅BrN₄O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20℃; for 8h;	[00220] To a solution of compound IV-1 (105 mg, 0.37 mmol) in DMF (3 mL) was added carboxylic acid V-3 (120 mg, 0.56 mmol), N,N-diisopropylethylamine (130 iL, 0.93 mmol) followed by propylphosphonic anhydride solution (T3P, 50 wt.% in ethyl acetate, 330 iL, 0.56 mmol). The mixture was allowed to stir at rt for 8 h and diluted with H20 (20 mL) and ethyl acetate (30 mL). The aqueous phase was extracted with ethyl acetate (2 x 20 mL). The combined organic layers were washed with brine (30 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel eluting with Hexanes/ethyl acetate (4/6) to afford compound 111-3 (150 mg, 84%) as an orange solid. LC-MS tR = 1.77 mm in 2 mm chromatography, MS (ESI) m/z 480, 482 [M + H]. ?H NMR (CD3OD, 400MHz): 5 8.61 (s, 1H), 7.98 (d, J= 8.4 Hz, 1H), 7.39 (d, J= 8.4 Hz, 1H), 4.73-4.64 (m, 2H), 4.5 1-4.44 (m, 1H), 3.97 (s, 2H), 2.46- 2.40 (m, 1H), 1.51 (s, 9H), 1.14-1.11 (m, 3H), 0.65-0.61 (m, 3H).

Reference： [1]Patent: WO2014/179564,2014,A1 .Location in patent: Paragraph 00220

13
[ 192642-85-6 ]
methyl 6-(2-oxo-2-(piperidin-1-yl)ethyl)nicotinate [ No CAS ]

Reference： [1]Patent: WO2016/34673,2016,A1

14
[ 192642-85-6 ]
6-(2-oxo-2-(piperidin-1-yl)ethyl)nicotinic acid [ No CAS ]

Reference： [1]Patent: WO2016/34673,2016,A1

15
[ 110-89-4 ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-1-(piperidin-1-yl)ethanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20℃;	To a solution of <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> 167 (890 mg, 4.1 mmol) in DCM (5 mL) was added HATU (2.4 g, 6.2 mmol) followed by a solution of piperidine (526 mg, 6.2 mmol) in DCM (5 mL) and DIPEA (1.9 mL, 14.4 mmol). The resulting mixture was stirred at room temperature overnight. Water (15 mL) and DCM (15 mL) were then added, the layers were separated and the aqueous layer extracted with DCM (3 x 15 mL). The combined organic extracts were washed with saturated NaHCOa (3 x 10 mL) and brine (3 x 10 mL), dried ( a2S04) and concentrated in vacuo. The residue was purified by silica gel chromatography (ethyl acetate /petroleum ether = 1/10) to give the title compound as a white solid (960 mg, 82%). 1 HNMR (400 MHz, DMSO-cfe) delta 8.59 (d, J = 2.4 Hz, 1 H), 7.97 (dd, J =8.4, 2.4 Hz, 1 H), 7.28 (d, J = 8.4 Hz, 1 H), 3.83 (s, 2H), 3.45-3.40 (m, 4H), 1 .58-1 .52 (m, 2H), 1 .43-1.37 (m. 4H); LCMS-C: RT 2.22 min; m/z 283.1 [M+H]+

Reference： [1]Patent: WO2016/34673,2016,A1 .Location in patent: Page/Page column 100

16
[ 1415397-18-0 ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(5-(4-(5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2016,vol. 7,p. 520 - 524

17
[ 722-92-9 ]
[ 192642-85-6 ]
2-(5-bromo-2-pyridyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
820 mg	With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 1h;	i) To a solution of <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (500 mg) in DCM (4 mL) were added 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (625 mg), EDCl (476 mg) and DMAP (57 mg). The reaction mixture was stirredat RT for 1 hour, poured into water, filtered on a water repellent filter cartridge and concentrated under reducedpressure. The residue was purified by column chromatography on silica gel, using 10% EtOAc in heptane as theeluent, followed by trituration with ether/pentane to obtain 820 mg of the expected compound. MS(ES+) m/z 456.9[M+H]+.

Reference： [1]Patent: EP3101005,2016,A1 .Location in patent: Paragraph 0166

18
[ 722-92-9 ]
[ 192642-85-6 ]
2-[5-(cyclopropylmethylsulfonyl)-2-pyridyl]-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide [ No CAS ]

Reference： [1]Patent: EP3101005,2016,A1

19
1,3-bis(N-benzyloxycarbonyl)-3′-dihyro-3′-deoxy-3′(R)-amino spectinomycin [ No CAS ]
[ 192642-85-6 ]
C₃₇H₄₃BrN₄O₁₁ [ No CAS ]

Reference： [1]ACS Infectious Diseases,2017,vol. 3,p. 72 - 88

20
[ 192642-85-6 ]
methyl 3-benzoyl-6-bromoindolizine-1-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 1630 - 1639

21
[ 192642-85-6 ]
methyl 6-bromo-3-(3,5-dimethylbenzoyl)indolizine-1-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 1630 - 1639

22
[ 192642-85-6 ]
methyl 6-bromo-3-(3,5-difluorobenzoyl)indolizine-1-carboxylate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 1630 - 1639

23
[ 56547-82-1 ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; at 20℃; for 1h;	General procedure: In a 1 dram vial, to a stirred solution of bicyclo[2.2.1]heptan-2-amine (15.0 mg, 0.13 mmol), 2-(5-phenyl-2H-tetrazol-2-yl)acetic acid (27.0 mg, 0.13 mmol) and TEA (54.8 muL, 0.40 mmol) in DCM (1 mL) was dropwise added propylphosphonic anhydride solution ?50 wt. % in ethyl acetate (107.4 muL, 0.16 mmol). The reaction was stirred at RT for 1 hour. The product was partitioned between ethyl acetate (15 mL * 2) and water (15 mL). Organic layers were combined, washed with brine, dried over sodium sulphate, concentrated and purified by reverse phase preparative chromatography (0-100% ACN in water). (28.0 mg, 70%)

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,p. 791 - 796

24
[ 56547-82-1 ]
[ 192642-85-6 ]
N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)-2-(5-phenylpyridin-2-yl)acetamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,p. 791 - 796

25
4-((benzyl(propyl)amino)methyl)-3-chloroaniline [ No CAS ]
[ 192642-85-6 ]
N-(4-[benzyl(propyl)amino]methyl}-3-chlorophenyl)-2-(5-bromopyridin-2-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59.7%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 5h;	4-((Benzyl)propylamino)methyl)-3-chloroaniline (200 mg, 0.69 mmol), <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (200 mg) was added to a 50 mL single-necked bottle. 0.93mmol), HATU (400mg, 1.05mmol),DIPEA(425 muL, 2.58 mmol), 30 mL of dichloromethane.After stirring at room temperature for 5 hours, the reaction was completed by TLC.Purification of dichloromethane by column chromatography: methanol 50:1,Obtained 200 mg of a white solid product.The yield was 59.7%.

Reference： [1]Patent: CN109206346,2019,A .Location in patent: Paragraph 0558; 0561; 0562; 0563

26
[ 1099073-00-3 ]
[ 192642-85-6 ]
C₂₄H₂₆BrN₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56.9%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 5h;	4-((Benzyl(propyl)amino)methyl)aniline (200 mg, 0.78 mmol) was added sequentially to a 50 mL vial, <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (200 mg.0.93 mmol), HATU (400 mg, 1.05 mmol), DIPEA (425 muL,2.58 mmol), 30 mL of dichloromethane.Stir at room temperature for 5 hours.The reaction was completed by TLC.Purification of dichloromethane by column chromatography:Methanol 50:1 gave a white solid product of 200 mg.The yield was 56.9%.

Reference： [1]Patent: CN109206346,2019,A .Location in patent: Paragraph 0540; 0549; 0550; 0551

27
3-chloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)aniline [ No CAS ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(3-chloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)phenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62.8%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 5h;	3-chloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)aniline was added sequentially to a 50 mL single-mouth bottle(200mg, 0.68mmol),2-(5-Bromopyridin-2-yl)acetic acid (200 mg. 0.93 mmol), HATU (400 mg, 1.05 mmol),DIPEA (425 muL, 2.58 mmol), dichloromethane 30 mL.After stirring at room temperature for 5 hours, the reaction was completed by TLC.Purification of dichloromethane by column chromatography: methanol 50:1,Obtained 210 mg of a white solid product.The yield was 62.8%.

Reference： [1]Patent: CN109206346,2019,A .Location in patent: Paragraph 0582; 0585; 0586; 0587

28
3,5-dichloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)aniline [ No CAS ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(3,5-dichloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)phenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62.5%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 5h;	Add 3,5-dichloro-4-(((cyclohexylmethyl)(propyl)amino)methyl)aniline to a 50 mL single-mouth bottle(200mg, 0.61mmol),<strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (200 mg.0.93 mmol),HATU (400mg, 1.05mmol),DIPEA (425 muL, 2.58 mmol), dichloromethane 30 mL.After stirring at room temperature for 5 hours, the reaction was completed by TLC.Purification of dichloromethane by column chromatography: methanol 50:1,Obtained 200 mg of a white solid product.The yield was 62.5%.

Reference： [1]Patent: CN109206346,2019,A .Location in patent: Paragraph 0594; 0597; 0598; 0599

29
4-((benzyl(propyl)amino)methyl)-3,5-dichloroaniline [ No CAS ]
[ 192642-85-6 ]
C₂₄H₂₄BrCl₂N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59.7%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 5h;	4-((Benzyl)propylamino)methyl)-3-chloroaniline (200 mg, 0.69 mmol) was added sequentially to a 50 mL vial.2-(5-Bromopyridin-2-yl)acetic acid (200 mg. 0.93 mmol), HATU (400 mg, 1.05 mmol),DIPEA(425 muL, 2.58 mmol), 30 mL of dichloromethane. Stir at room temperature for 5 hours.The reaction was completed by TLC. Purification of dichloromethane by column chromatography:Methanol 50:1,White solid product200mg,The yield was 59.7%.

Reference： [1]Patent: CN109206346,2019,A .Location in patent: Paragraph 0570; 0573; 0574; 0575

30
C₁₆H₁₅F₃N₂ [ No CAS ]
[ 192642-85-6 ]
C₂₃H₁₉BrF₃N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%		At room temperature, Compound 8 (0.72 g, 2.47 mmol, 1.0 eq), 9 (0.53 g, 2.47 mmol, 1.0 eq) was added to 20 mL DMF. After stirring for 5 min, DIEA (1.27 g, 9.9 mmol, 4.0 eq) was added and stirred at room temperature for 6 hours. The reaction was monitored by TLC, and 30 mL of EA and 50 mL of water were added to the mixture. The liquid phase was separated, and the aqueous phase was extracted three times with 50 mL of EA. The organic phase was combined, and the organic phase was washed with water and saturated sodium chloride. The organic phase was dried over anhydrous sodium sulfate. The mixture was spin-dried under reduced pressure to give compound 10 (0.70 g, yield: 58%).

Reference： [1]Patent: CN109384711,2019,A .Location in patent: Paragraph 0127; 0164; 0165; 0166; 0167; 0168; 0169

31
C₁₈H₁₉F₃N₂ [ No CAS ]
[ 192642-85-6 ]
C₂₅H₂₃BrF₃N₃O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%		At room temperature, Compound 9 (0.18 g, 0.56 mmol, 1.0 eq), 10 (0.134 g, 0.62 mmol, 1.1 eq), HATU (0.319 mg, 0.84 mmol, 4.0 eq) was added to 20 mL DMF. Stirred for 5min, added DIEA (0.289mg, 2.2mmol, 4.0eq), stirred at room temperature for 2h. The reaction was monitored by TLC, and 30 mL of EA and 50 mL of water were added to the mixture. The liquid phase was separated, and the aqueous phase was extracted three times with 50 mL of EA. The organic phase was combined, and the organic phase was washed with water and saturated sodium chloride. The organic phase was dried over anhydrous sodium sulfate. The mixture was dried under reduced pressure and passed through a column (PE: EA = 20:1 to 5:1) to afford compound 11 (0.18 g, yield: 63%).

Reference： [1]Patent: CN109384711,2019,A .Location in patent: Paragraph 0185; 0228; 0229; 0230; 0231; 0232; 0233

32
C₁₅H₂₅NOSi [ No CAS ]
[ 192642-85-6 ]
C₂₂H₂₉BrN₂O₂Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 16h;	Compound 3 (0.2 g, 0.76 mmol, 1.0 eq), Compound 4 (182 mg, 0.84 mmol, 1.1 eq) was dissolved in DMF (5 mL). Then, HATU (433 mg, 1.14 mmol, 1.5 eq) was added, followed by DIEA (386 mg, 3.04 mmol, 4.0 eq), and allowed to react at room temperature for 16 hours. TLC showed little residue of compound 3, EA (10 mL), water was added and the organic phase was separated. The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and rotary evaporation under reduced pressure to give compound 5 (200mg, yield: 76%).

Reference： [1]Patent: CN109384711,2019,A .Location in patent: Paragraph 0254; 0268; 0269; 0270

33
[ 192642-85-6 ]
C₂₅H₂₄N₆O₃ [ No CAS ]

Reference： [1]Patent: WO2019/51265,2019,A1

34
[ 192642-85-6 ]
C₂₅H₂₃FN₆O₂ [ No CAS ]

Reference： [1]Patent: WO2019/51265,2019,A1

35
[ 371-40-4 ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(4-fluorophenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20℃; for 2h;	2-(5-Bromopyridin-2-yl)acetic acid (200 mg, 0.93 mmol),4-fluoroaniline (103 mg, 0.93 mmol),HATU (353mg, 0.93mmol)After stirring with TEA (188 mg, 1.86 mmol) in DMF (10 mL) at room temperature for 2 h,Water (50 mL) was poured and extracted with ethyl acetate (2×50 mL).The organic phase was separated and washed with saturated aqueous NaCl (2×).The organic phase was separated and dried over anhydrous Na 2 SO 4Filter and concentrate, and the residue was purified by silica gel column chromatography.Elution with ethyl acetate/petroleum ether (1:3) gave the desired compound 18 (250 mg, 87%).

Reference： [1]Patent: CN110218182,2019,A .Location in patent: Paragraph 0295-0300

36
[ 371-40-4 ]
[ 192642-85-6 ]
N-(4-fluorophenyl)-2-(5-(6-fluoroquinolin-4-yl)pyridin-2-yl)acetamide [ No CAS ]

Reference： [1]Patent: CN110218182,2019,A

37
4'-amino-2',6'-dichloro-4-isobutyl-[1,1'-biphenyl]-3-carbonitrile [ No CAS ]
[ 192642-85-6 ]
2-(5-bromopyridin-2-yl)-N-(2,6-dichloro-3'-cyano-4'-isobutyl-[1,1'-biphenyl]-4-yl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 3h;	4'-Amino-2',6'-dichloro-4-isobutyl-[1,1'-biphenyl]-3-carbonitrile (100 mg, 0.31 mmol), <strong>[192642-85-6]2-<strong>[192642-85-6](5-bromopyridin-2-yl)acetic acid</strong></strong> (80 mg, 0.37 mmol), HATU (141 mg, 0.37 mmol), N,N-diisopropylethylamine (120 mg, 0.93 mmol) and dichloromethane (5 mL) were added in a 25 mL single-neck flask, and the mixture was reacted at room temperature for 3 hours. Then dichloromethane (10 mL) was added, and the mixture was washed with saturated ammonium chloride, and then with saturated sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to remove the solvent to obtain a crude product (200 mg), which was used for the next step directly.

Reference： [1]Patent: EP3581561,2019,A1 .Location in patent: Paragraph 0103-0104

38
[ 192642-85-6 ]
2-(5-bromo-2-pyridyl)ethyl methanesulfonate [ No CAS ]

Reference： [1]Patent: EP3628672,2020,A1

39
[ 192642-85-6 ]
4-[2-(5-bromo-2-pyridyl)ethyl]morpholine [ No CAS ]

Reference： [1]Patent: EP3628672,2020,A1

40
[ 2620-50-0 ]
[ 192642-85-6 ]
C₁₅H₁₃BrN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 6h;	Synthesis of intermediate 3b Add 1 equivalent of 2-(5-bromopyridin-2-yl)acetic acid (1) to the reaction flask, dissolve it with enough DMF, and then add 2 equivalents of 3,4-methylenedioxybenzylamine and 2 The equivalent of the catalyst HATU was reacted at room temperature for 6 hours.After the reaction was completed, a large amount of water was added to precipitate a white solid, which was suction filtered, and the filter cake was washed 3 times with water.The intermediate 3b was obtained by drying the filter cake with a yield of 90%.

Reference： [1]Current Patent Assignee: CHENGDU ZELING BIOMEDICAL TECH - CN113461665, 2021, A Location in patent: Paragraph 0128-0130

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
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Code	Phrase
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 192642-85-6 ] {[proInfo.proName]}

Quality Control of [ 192642-85-6 ]

Related Doc. of [ 192642-85-6 ]

Product Details of [ 192642-85-6 ]

Calculated chemistry of [ 192642-85-6 ]

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

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Application In Synthesis of [ 192642-85-6 ]

[ 192642-85-6 ] Synthesis Path-Upstream 1~6

[ 192642-85-6 ] Synthesis Path-Downstream 1~40

Related Functional Groups of [ 192642-85-6 ]

Bromides

Carboxylic Acids

Related Parent Nucleus of [ 192642-85-6 ]

Pyridines

Precautionary Statements-General

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[ 192642-85-6 ]

Related Parent Nucleus of
[ 192642-85-6 ]