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[ CAS No. 19482-11-2 ]

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2D
Chemical Structure| 19482-11-2
Chemical Structure| 19482-11-2
Structure of 19482-11-2 *Storage: {[proInfo.prStorage]}

Quality Control of [ 19482-11-2 ]

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Alternatived Products of [ 19482-11-2 ]

Product Details of [ 19482-11-2 ]

CAS No. :19482-11-2MDL No. :MFCD06201392
Formula : C13H11Cl Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :202.68Pubchem ID :2757677
Synonyms :

Computed Properties of [ 19482-11-2 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 19482-11-2 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19482-11-2 ]

  • Downstream synthetic route of [ 19482-11-2 ]

[ 19482-11-2 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 106-47-8 ]
  • [ 19482-11-2 ]
  • [ 89346-57-6 ]
  • 2
  • [ 2028-84-4 ]
  • [ 108-90-7 ]
  • [ 19482-11-2 ]
  • [ 19493-33-5 ]
  • 3
  • [ 10312-71-7 ]
  • [ 108-88-3 ]
  • [ 19482-11-2 ]
  • [ 89346-57-6 ]
  • [ 19482-10-1 ]
  • [ 103-29-7 ]
  • 4
  • [ 673-41-6 ]
  • [ 108-88-3 ]
  • [ 19482-11-2 ]
  • [ 89346-57-6 ]
  • [ 19482-10-1 ]
  • 5
  • [ 637-87-6 ]
  • [ 624-31-7 ]
  • [ 19482-11-2 ]
  • 6
  • bis(4-chlorophenyl)iodonium tetrafluoroborate [ No CAS ]
  • potassium (4-methylphenyl)trifluoroborate [ No CAS ]
  • [ 19482-11-2 ]
YieldReaction ConditionsOperation in experiment
> 90% With palladium diacetate; In ethanol; water; ethylene glycol; at 20℃; for 24h; General procedure: As shown in the above scheme, 82 mg (0.18 mmol) of potassium salt of a stable art type complex of 4-methylphenylboronic acid and scyllo-inositol, 0.40 mmol of an aryl Br compound having various substituents,1.7 mg (0.01 mmol) of palladium acetate as a catalyst, Triphenylphosphine ligand-palladium4.3 mg (0.01 mmol) was suspended in 3.6 mL of a mixed solvent of ethanol: water: ethylene glycol (4: 1: 1) as a reaction solvent or 3.6 mL of a mixed solvent of ethanol: water (5: 1) And the mixture was stirred at room temperature for 24 hours. For the evaluation after the reaction, 2 mul of the reaction solution was developed with a solvent of ethyl acetate: hexane (1: 1) using silica gel TLC to develop the raw material 4-methylphenylboronic acid with potassium permanganate and analyzed by image analysis The degree of decrease was measured and the reaction conversion rate was calculated. However, because image analysis has low accuracyEvaluation is made in units of 10%. The results are shown in the following table.
87% With bis(benzonitrile)palladium(II) dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50℃; for 3h; General procedure: 1 mmol of aromatic hydrazine, 1.2 mmol of aryl silicone ether,0.05 mmol of divalent palladium catalyst and 1 mmol of camphorsulfonic acid (CSA)A round bottom flask containing 1 ml of TBAF (1 M) in tetrahydrofuran was added and stirred at 50 C for 3 hours.After the reaction is completed, the temperature is lowered to room temperature, and the solid is filtered off. After the solvent is dried, the column is separated to obtain a product.The raw materials, catalysts and reaction results used are shown in Table 1.
78% With sodium methylate; In 1,4-dioxane; at 100℃; for 24h;Schlenk technique; Inert atmosphere; General procedure: [0037] According to one aspect, the method may be performed in a Schienk flask. According to the method to obtain the biaryl molecule, GO-PdNPs catalyst of about ic mg is taken. The GO-PdNPs is obtained by the method described above. According to an aspect, the GO-PdNPs is mixed with substrates, aryl halide (i mmol) and phenyl boronic acid (1.5 mmol); and base NaOMe (2 mmol). The mixture is subjected to high vacuum. The vacuum removes oxygen, moisture and other volatile reactive elements from the mixture. In one embodiment, the mixture may be subjected to vacuum for about one hour; the time however may be decided based on the quantity of the mixture. According to a further aspect, the dry dioxane ( mL) is added to the mixture under N2 atmosphere followed by the addition of liquid substrates (if any) in the requisite amounts. The dioxane dissolves aryl halide, phenyl boronic acid and partially dissolves sodium methoxide. Nitrogen creates substantially inert environment. Further, subjecting the mixture to high vacuum could result into vaporization of liquid aryl halides; therefore, liquid substrates (aryl halides) may be added to the mixture after a nitrogenous environment is created. The mixture is then heated at about icc degree Celsius for about 24 hours under nitrogenous environment. In some embodiments, the time for heating the mixture may be determined based on quantity of the mixture. Furthermore, the temperature at which the mixture is heated is determined based on the temperature at which cross-coupling reaction starts but the temperature is kept below the temperature at which the structure of the catalyst deforms. The catalyst and biaryl molecule are extracted, by cooling the mixture at room temperature, filtration using a membrane paper and washing of the reaction mixture and the desired biaryl molecule is then purified employing vaporization under reduced pressure and short column chromatography (silica gel 100-200 mesh) etc.
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