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Chemical Structure| 19482-24-7 Chemical Structure| 19482-24-7

Structure of 19482-24-7

Chemical Structure| 19482-24-7

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Product Details of [ 19482-24-7 ]

CAS No. :19482-24-7
Formula : C13H11Cl
M.W : 202.68
SMILES Code : CC1=CC=C(Cl)C(C2=CC=CC=C2)=C1
MDL No. :MFCD14701656

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Application In Synthesis of [ 19482-24-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19482-24-7 ]

[ 19482-24-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57310-39-1 ]
  • [ 98-80-6 ]
  • [ 19482-24-7 ]
YieldReaction ConditionsOperation in experiment
90% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 100℃; for 16h; EXAMPLE 2 4-Amino-l -(7H-pyrrolo['2,3-d1pyriniidin-4-ylVpiperidine-4-carboxylic acid (6- chloro-biphenyl-3-ylmethylVamide hydrochloride2A. 2-Chloro-5-methyl-biphenylA mixture of 2-bromo-l-chloro-4-methyl-benzene (4.83 g, 23.4 mmol), benzeneboronic acid (5.7 g, 46.7 mmol), Pd(Ph3P)4 (1.35 g, 1.2 mmol) and 2M Na2CO3 (34 mL) in DME (100 mL) was stirred at 1000C under N2 for 16 h. After cooling, the resulting suspension was filtered. The filtrate was diluted with saturated brine and extracted with ethyl acetate (2 x 150 mL). The combined organic layers were washed with brine (100 mL) and water (100 mL), dried (Na2SO4) and filtered through decolourising charcoal. After evaporation of the solvent, n-hexane was added to the oil. The mixture was filtered to remove solids and the filtrate was concentrated. The resulting crude oil was purified by silica column chromatography (ethyl acetate : n-hexane / 1 : 20) to give the title <n="90"/>compound (1.76g, 90 %) as a light yellow oil. Rf= 0.55. GC-MS (EI) m/z 202.3 [M]+, Rt 3.41 min. 1H (500 MHz, CDCl3) delta 7.64 (IH, d, J = 7.5 Hz), 7.50-7.35 (5H, m), 7.15 (IH, s), 7.12 (IH, d, J = 7.5 Hz), 2.39 (3H, s).
 

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