Alternatived Products of [ 19614-14-3 ]
Product Details of [ 19614-14-3 ]
| CAS No. : | 19614-14-3 |
MDL No. : | MFCD28361827 |
| Formula : |
C9H11Br
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | SRXJZMLETPOSSJ-UHFFFAOYSA-N |
| M.W : |
199.09
|
Pubchem ID : | 15748977 |
| Synonyms : |
|
Application In Synthesis of [ 19614-14-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 19614-14-3 ]
- Downstream synthetic route of [ 19614-14-3 ]
- 1
-
[ 103-65-1 ]
-
[ 19614-14-3 ]
-
[ 588-93-2 ]
- 2
-
triethyl-orthoacetate
[ No CAS ]
-
[ 19614-14-3 ]
-
[ 1147-43-9 ]
-
[ 158425-08-2 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With hydrazine; In propionic acid anhydride; |
EXAMPLE 199 3-Methyl-1-[2-[(1-oxopropyl)amino]phenyl]-4-(3-phenylpropyl)-1H-2,4-benzodiazepine (Formula I: R1, R4, R6 =H; R2 =(CH2)3Ph; R3 =Me; R5 = STR258 By a procedure analogous to that of Example 41, it is contemplated that 1-(2-aminophenyl)-4-(3-phenylpropyl)-3-methyl-1H-2,4-benzodiazepine can be synthesised from 2-(2-aminobenzoyl)-benzoic acid, hydrazine, bromobenzenepropane and triethyl-orthoacetate. It is further contemplated that this product may be acylated by treatment with propionic anhydride at room temperature to produce 3-methyl-1-[2-[(1-oxopropyl)amino]-phenyl]-4-(3-phenylpropyl)-1H-2,4-benzodiazepine. |
- 3
-
[ 19614-14-3 ]
-
[ 551-16-6 ]
-
γ-Phenylpropyl 6-aminopenicillanate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
With sodium hydrogencarbonate; triethylamine; In N-methyl-acetamide; water; ethyl acetate; |
A. gamma-Phenylpropyl 6-aminopenicillanate To a stirred suspension of <strong>[551-16-6]6-aminopenicillanic acid</strong> (21.6 g.) in dimethylformamide (200 ml.) triethylamine (11.4 ml.) and gamma-bromophenylpropane (22.0 g.) was added at room temperature. Stirring was continued at room temperature for 18 hours. 200 ml. of ethyl acetate was added and the mixture filtered. The filtrate was diluted with 400 ml. of ethyl acetate, extracted four times with 100 ml. of water and dried over magnesium sulfate. After evaporation in vacuo, the oily residue was dissolved in a mixture of water and ether (200 ml. of each) with stirring and ice-cooling. By slow addition of diluted hydrochloric acid the pH was adjusted to 3 to 4. The aqueous phase was separated, made alkaline to pH of about 7.5 by addition of sodium bicarbonate and extracted with ether. After drying, the ether was evaporated in vacuo to leave the crude ester as an oil. |
|
With sodium hydrogencarbonate; triethylamine; In N-methyl-acetamide; water; ethyl acetate; |
A. gamma-phenylpropyl 6-aminopenicillanate To a stirred suspension of <strong>[551-16-6]6-aminopenicillanic acid</strong> (21.6 g) in dimethylformamide (200 ml), triethylamine (11.4 ml) and gamma-bromophenylpropane (22.0 g) were added at room temperature. Stirring was continued at room temperature for 18 hours. 200 ml of ethyl acetate were added, and the mixture was filtered. The filtrate was diluted with 400 ml of ethyl acetate, extracted four times with 100 ml of water and dried over magnesium sulfate. After evaporation in vacuo, the oily residue was dissolved in a mixture of water and ether (200 ml of each) with stirring and ice-cooling. By slow addition of diluted hydrochloric acid the pH was adjusted to 3 to 4. The aqueous phase was separated, made alkaline to a pH of about 7.5 by addition of sodium bicarbonate, and extracted with ether. After drying, the ether was evaporated in vacuo to leave the crude ester as an oil. |
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