19686-05-6|2,8-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole| Ambeed

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CAS No. :	19686-05-6
Formula :	C₁₃H₁₆N₂
M.W :	200.28
SMILES Code :	CC1=CC2=C(NC3=C2CN(C)CC3)C=C1
MDL No. :	MFCD00452533

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 150℃; for 16h;	Example No. 19; Preparation of Compound No. 19[0316] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.2 g, lmmol), <strong>[34259-99-9]4-bromo-thiazole</strong> (0.246 g, 1.5 mmol), K3P04 (0.636 g, 3 mmol), Cul (19 mg, 0.1 mmol) and L-Proline (23 mg, 0.2 mmol) in dry DMF (5 mL) was stirred at 150 °C for 16h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude material, which was purified by reverse phase HPLC to yield 2,8-dimethyl-5-thiazol-4- yl-2,3,4,5-tetrahydro-lH-pyrido[4,3-b]indole (59 mg). 1H NMR (TFA salt, CD3OD) d (ppm): 9.10 (s, 1H), 7.62 (s, 1H), 7.38 (d, 1H), 7.30 (s, 1H), 7.10 (d, 1H), 4.70 (d, 1H), 4.30 (d, 1H), 3.80 (m, 1H), 3.50 (m, 1H), 3.26 (m, 1H), 3.18 (s, 3H), 3.16 (m, 1H), 2.42 (s, 3H).
	With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 150℃; for 16h;	Example No. 19: Preparation of Compound No. 19[0307] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.2 g, lmmol), <strong>[34259-99-9]4-bromo-thiazole</strong> (0.246 g, 1.5 mmol), K3P04 (0.636 g, 3 mmol), Cul (19 mg, 0.1 mmol) and L- Proline (23 mg, 0.2 mmol) in dry DMF (5 mL) was stirred at 150 °C for 16h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude material, which was purified by reverse phase HPLC to yield 2,8-dimethyl-5-thiazol-4-yl-2,3,4,5- tetrahydro-lH-pyrido[4,3-b]indole (59 mg). 1H NMR (TFA salt, CD3OD) delta (ppm): 9.10 (s, 1H), 7.62 (s, 1H), 7.38 (d, 1H), 7.30 (s, 1H), 7.10 (d, 1H), 4.70 (d, 1H), 4.30 (d, 1H), 3.80 (m, 1H), 3.50 (m, 1H), 3.26 (m, 1H), 3.18 (s, 3H), 3.16 (m, 1H), 2.42 (s, 3H).

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 150℃; for 16h;	Example No. 58; Preparation of Compound No. 58 [0355] A solution of 2,8-dimethyl-2,3 ,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.1 g, 0.499 mmol), <strong>[63927-22-0]8-bromoisoquinoline</strong> (0.155 g, 0.748 mmol), potassium phosphate (0.317 g, 1.495 mmol), Cul (9 mg, 0.047 mmol) and L-Proline (11 mg, 0.095 mmol) in dry DMF (3 mL) was heated at 150 °C for 16h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude, which was purified by reverse phase HPLC to yield 5- (isoquinolin-8-yl)-2,8-dimethyl-2,3,4,5-tetrahydro-lH-pyrido[4,3-b]indole. 1H NMR (TFA salt, CD3OD) d (ppm): 8.8 (d, 1H), 8.62 (d, 1H), 8.42 (bs, 1H), 8.4 (d, 1H), 8.3 (t, 1H), 8.0 (d, 1H), 7.42 (s, 1H), 7.0 (d, 1H), 6.87 (bs, 1H), 4.7 (d, 1H), 4.3 (d, 1H), 3.8 (m, 1H), 3.6 (m, 1H), 3.16 (m, 4H), 2.8 (m, 1H), 2.4 (s, 3H).
	With potassium phosphate; copper(l) iodide; L-proline; In N,N-dimethyl-formamide; at 150℃; for 16h;	Example No. 58: Preparation of Compound No. 58[0346] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.1 g, 0.499 mmol), <strong>[63927-22-0]8-bromoisoquinoline</strong> (0.155 g, 0.748 mmol), potassium phosphate (0.317 g, 1.495 mmol), Cul (9 mg, 0.047 mmol) and L-Proline (11 mg, 0.095 mmol) in dry DMF (3 mL) was heated at 150 °C for 16h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain crude, which was purified by reverse phase HPLC to yield 5- (isoquinolin-8-yl)-2,8-dimethyl-2,3,4,5-tetrahydro-lH-pyrido[4,3-b]indole. 1H NMR (TFA salt, D o ( pm . , H , . , H , . s, H , . , H , eta nu alpha, ), 7.42 (s, 1H), 7.0 (d, 1H), 6.87 (bs, 1H), 4.7 (d, 1H), 4.3 (d, 1H), 3.8 (m, 1H), 3.6 (m, 1H), 3.16 (m, 4H), 2.8 (m, 1H), 2.4 (s, 3H).

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CAS No.: 19686-05-6

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CAS No.: 19686-05-6

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Code	Phrase
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