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Chemical Structure| 198084-12-7 Chemical Structure| 198084-12-7

Structure of 198084-12-7

Chemical Structure| 198084-12-7

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Product Details of [ 198084-12-7 ]

CAS No. :198084-12-7
Formula : C11H8N2O
M.W : 184.19
SMILES Code : C2=C(C1=CN=CN=C1)C=CC(=C2)C=O
MDL No. :MFCD02684108
InChI Key :BXNXTOLXLPQMHS-UHFFFAOYSA-N
Pubchem ID :3861212

Safety of [ 198084-12-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 198084-12-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 198084-12-7 ]

[ 198084-12-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15862-94-9 ]
  • [ 198084-12-7 ]
  • 2-(4,5-dimethoxy-2-nitrophenyl)-1-(4-(pyrimidin-5-yl)phenyl)ethanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% General procedure: To a glass vessel suitable for sealing with Teflon cap (for microwave vials) were added <strong>[15862-94-9]1-(chloromethyl)-4,5-dimethoxy-2-nitrobenzene</strong> (1 equiv.) [34] and benzaldehyde derivative (3 equiv.) The vessel was capped and then evacuated and backfilled with N2 (thrice-repeated process). Anhydrous DMF (3.5mL/mmol) was introduced and the solution was vigorously stirred for 20minat-20C. TDAE (1.06 equiv.) was added slowly and the mixture was stirred for one hour. Then, the reaction was stirred at room temperature overnight. After LC-MS analysis clearly showed that the chloride had been totally consumed, the reaction was hydrolyzed with water. The mixture was then extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered off, and concentrated under reduced pressure to afford the corresponding crude product.
 

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