Home Cart Sign in  
Chemical Structure| 198205-95-7 Chemical Structure| 198205-95-7

Structure of 198205-95-7

Chemical Structure| 198205-95-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 198205-95-7 ]

CAS No. :198205-95-7
Formula : C14H9F3O
M.W : 250.22
SMILES Code : C1=CC=CC(=C1C2=CC=C(C=C2)C=O)C(F)(F)F
MDL No. :MFCD01631916
InChI Key :SDDRLRQYSYHJED-UHFFFAOYSA-N
Pubchem ID :1392653

Safety of [ 198205-95-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 198205-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 198205-95-7 ]

[ 198205-95-7 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 392-83-6 ]
  • [ 87199-17-5 ]
  • [ 198205-95-7 ]
YieldReaction ConditionsOperation in experiment
88% With sodium carbonate In 1,4-dioxane; water at 80 - 100℃; To a stirred solution of 2-trifluromethyl-bromobenzene (0.7 g, 2.75 mmol) and 4-carbaldehyde boronic acid (0.5 g, 3.3 mmol) in dioxane (20 ml_) under nitrogen at 80 5C was added Pd(PPh3)4 (0.05 g) followed by the addition of a solution of Na2CO3 (0.7 g) in H2O (5 m). The mixture was stirred at 100 5C for 6 h. The solvent was evaporated and the residue was diluted to 50 ml with EtOAc and washed with H2O. The solvent was devaporated to dryness and the residue was purified by FCC (SiO2) to give the title compound (0.61 g; 88percent), as creamy solid. 1H-NMR (CDCI3) 7.49 (d, 1 H, J = 7.41 Hz); 7.48 (d, 2H, J = 8.13 Hz); 7.61 - 7.53 (m, 2H); 7.76 (d, 1 H, J = 7.8 Hz); 7.91 (d, 2H, J = 8.34 Hz); 10.07 (s, 1 H).
References: [1] Patent: WO2010/42998, 2010, A1, . Location in patent: Page/Page column 95.
  • 2
  • [ 1423-27-4 ]
  • [ 1122-91-4 ]
  • [ 198205-95-7 ]
References: [1] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2975 - 2990.
[2] Patent: WO2005/118542, 2005, A1, . Location in patent: Page/Page column 59.
  • 3
  • [ 392-83-6 ]
  • [ 104-88-1 ]
  • [ 198205-95-7 ]
References: [1] Organic Letters, 2012, vol. 14, # 17, p. 4606 - 4609.
  • 4
  • [ 444-29-1 ]
  • [ 1122-91-4 ]
  • [ 198205-95-7 ]
References: [1] Tetrahedron Letters, 2004, vol. 45, # 20, p. 3909 - 3912.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 198205-95-7 ]

Fluorinated Building Blocks

Chemical Structure| 343604-24-0

A366583 [343604-24-0]

4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 1.00

Chemical Structure| 30071-93-3

A107409 [30071-93-3]

1-(3,5-Bis(trifluoromethyl)phenyl)ethanone

Similarity: 0.93

Chemical Structure| 349-76-8

A116660 [349-76-8]

3'-(Trifluoromethyl)acetophenone

Similarity: 0.93

Chemical Structure| 878001-20-8

A993787 [878001-20-8]

2-Methyl-3-(trifluoromethyl)benzaldehyde

Similarity: 0.93

Chemical Structure| 401-95-6

A111403 [401-95-6]

3,5-Bis(trifluoromethyl)benzaldehyde

Similarity: 0.92

Aryls

Chemical Structure| 343604-24-0

A366583 [343604-24-0]

4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 1.00

Chemical Structure| 30071-93-3

A107409 [30071-93-3]

1-(3,5-Bis(trifluoromethyl)phenyl)ethanone

Similarity: 0.93

Chemical Structure| 349-76-8

A116660 [349-76-8]

3'-(Trifluoromethyl)acetophenone

Similarity: 0.93

Chemical Structure| 878001-20-8

A993787 [878001-20-8]

2-Methyl-3-(trifluoromethyl)benzaldehyde

Similarity: 0.93

Chemical Structure| 401-95-6

A111403 [401-95-6]

3,5-Bis(trifluoromethyl)benzaldehyde

Similarity: 0.92

Aldehydes

Chemical Structure| 343604-24-0

A366583 [343604-24-0]

4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 1.00

Chemical Structure| 878001-20-8

A993787 [878001-20-8]

2-Methyl-3-(trifluoromethyl)benzaldehyde

Similarity: 0.93

Chemical Structure| 401-95-6

A111403 [401-95-6]

3,5-Bis(trifluoromethyl)benzaldehyde

Similarity: 0.92

Chemical Structure| 455-19-6

A226445 [455-19-6]

1-Formyl-4-trifluoromethylbenzene

Similarity: 0.92

Chemical Structure| 447-61-0

A329711 [447-61-0]

2-(Trifluoromethyl)benzaldehyde

Similarity: 0.92

Trifluoromethyls

Chemical Structure| 343604-24-0

A366583 [343604-24-0]

4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde

Similarity: 1.00

Chemical Structure| 30071-93-3

A107409 [30071-93-3]

1-(3,5-Bis(trifluoromethyl)phenyl)ethanone

Similarity: 0.93

Chemical Structure| 349-76-8

A116660 [349-76-8]

3'-(Trifluoromethyl)acetophenone

Similarity: 0.93

Chemical Structure| 878001-20-8

A993787 [878001-20-8]

2-Methyl-3-(trifluoromethyl)benzaldehyde

Similarity: 0.93

Chemical Structure| 401-95-6

A111403 [401-95-6]

3,5-Bis(trifluoromethyl)benzaldehyde

Similarity: 0.92