[ CAS No. 19872-91-4 ]

Name: 19872-91-4|Dimethyl 4-hydroxypyridine-2,6-dicarboxylate|98%
Brand: Ambeed
SKU: A288214
Price: 25.0 USD
Availability: InStock
Rating: 91 (22 reviews)

{[proInfo.proName]} ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 19872-91-4

Structure of 19872-91-4 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 100K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 19872-91-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 19872-91-4 ]

SDS Specification

Alternatived Products of [ 19872-91-4 ]

Product Details of [ 19872-91-4 ]

CAS No. :	19872-91-4	MDL No. :	MFCD00185834
Formula :	C₉H₉NO₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FERASHUCDLDGHK-UHFFFAOYSA-N
M.W :	211.17	Pubchem ID :	592568
Synonyms :

Safety of [ 19872-91-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 19872-91-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 19872-91-4 ]
Downstream synthetic route of [ 19872-91-4 ]

[ 19872-91-4 ] Synthesis Path-Upstream 1~2

1
[ 19872-91-4 ]
[ 5371-70-0 ]

Reference： [1] Arkivoc, 2011, vol. 2011, # 9, p. 77 - 93
[2] Chemistry Letters, 2018, vol. 47, # 3, p. 288 - 291

2
[ 19872-91-4 ]
[ 162102-79-6 ]

Reference： [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7267 - 7283
[2] Tetrahedron, 2008, vol. 64, # 2, p. 399 - 411
[3] Organic Letters, 2011, vol. 13, # 3, p. 442 - 445

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 19872-91-4 ]

Alcohols

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

[ 68631-52-7 ]

Diethyl 4-hydroxypyridine-2,6-dicarboxylate

Similarity: 0.96

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

Esters

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

[ 68631-52-7 ]

Diethyl 4-hydroxypyridine-2,6-dicarboxylate

Similarity: 0.96

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

Related Parent Nucleus of
[ 19872-91-4 ]

Pyridines

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

[ 68631-52-7 ]

Diethyl 4-hydroxypyridine-2,6-dicarboxylate

Similarity: 0.96

[ 1256633-27-8 ]

Methyl 4-hydroxypicolinate hydrochloride

Similarity: 0.98

[ 473269-77-1 ]

Methyl 4-hydroxypicolinate

Similarity: 0.98

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Yield	Reaction Conditions	Operation in experiment
	With methanol; sulfuric acid
	Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / Heating 2: dichloromethane

Yield	Reaction Conditions	Operation in experiment
60%	With pyridinium p-toluenesulfonate In dichloromethane at 20 - 50℃; for 20h;
	With pyridinium p-toluenesulfonate In dichloromethane Ambient temperature;

Yield	Reaction Conditions	Operation in experiment
92%	With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 4h;
90%	Stage #1: dimethyl 4-hydroxypyridine-2,6-dicarboxylate With potassium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: propargyl bromide In toluene; acetonitrile for 12h; Reflux;
80.8%	With potassium carbonate In acetonitrile for 24h; Heating;

Yield	Reaction Conditions	Operation in experiment
99%	With thionyl chloride at 20 - 60℃; for 26h;
99%	With thionyl chloride In methanol at 0 - 60℃; for 26h;
99%	With thionyl chloride at 0 - 65℃; for 26h;	1.0; 6.0 Dimethyl 4-hydroxypyridine-2,6-dicarboxylate (14). Thionyl chloride (SOCI2) (9.50 ml_, 0.130 mol, 5 equiv) was added slowly using a syringe to a stirred suspension of chelidamic acid monohydrate (5.28 g, 26.2 mmol, 1 equiv) in MeOH (60 ml.) in a two-neck round-bottom flask at 0 °C. The mixture was stirred at room temperature for 24 h and then refluxed for an additional 2 h. The solvent was removed under reduced pressure gently at room temperature and then D.l. water was added slowly at 0 °C. The mixture was neutralized with 1 M K2C03 in water solution and the precipitate was filtered by vacuum filtration, and then washed with 50% MeOH in water solution (~10 ml_). The white precipitate was dried under reduced pressure to give a white solid (5.54 g, >99%). 1H NMR (400 MHz, 298 K, (CD3)2SO): d 6.74 (s, 2H), 3.72 (s, 6H). 13C NMR (75 MHz, 298 K, (CD3)2SO): d 165.7, 149.2, 1 16.6, 52.7. LR-ESI-MS : calcd for [C9H9N05 + Na]+ 234.0; found [M + Na]+ 234.2

[ CAS No. 19872-91-4 ]

Quality Control of [ 19872-91-4 ]

Related Doc. of [ 19872-91-4 ]

Product Details of [ 19872-91-4 ]

Safety of [ 19872-91-4 ]

Application In Synthesis of [ 19872-91-4 ]

[ 19872-91-4 ] Synthesis Path-Upstream 1~2

[ 19872-91-4 ] Synthesis Path-Downstream 1~68