[ CAS No. 19886-78-3 ] {[proInfo.proName]}

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Quality Control of [ 19886-78-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 19886-78-3 ]

Product Details of [ 19886-78-3 ]

CAS No. :	19886-78-3	MDL No. :	MFCD08060611
Formula :	C₁₀H₁₃NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	163.22	Pubchem ID :	-
Synonyms :

Safety of [ 19886-78-3 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 19886-78-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 19886-78-3 ]

[ 19886-78-3 ] Synthesis Path-Downstream 1~52

1
[ 22826-55-7 ]
[ 19886-78-3 ]

Reference： [1]Archiv der Pharmazie,1954,vol. 287,p. 613,616

2
[ 19886-78-3 ]
phenylmagnesium bromide [ No CAS ]
[ 6969-97-7 ]

Reference： [1]Archiv der Pharmazie,1954,vol. 287,p. 613,616

3
[ 19886-78-3 ]
[ 98-86-2 ]
[ 110032-05-8 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 82,87

4
[ 109-80-8 ]
[ 19886-78-3 ]
[ 101707-70-4 ]

Reference： [1]Synthesis,1985,p. 698 - 699

5
[ 20320-37-0 ]
[ 19886-78-3 ]

Reference： [1]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 1953 - 1968

6
[ 19886-78-3 ]
[ 156-57-0 ]
Dimethyl-(2-thiazolidin-2-yl-benzyl)-amine [ No CAS ]

Reference： [1]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 1953 - 1968

7
[ 19886-78-3 ]
[ 65858-34-6 ]
[ 127136-93-0 ]

Reference： [1]Chemistry Letters,1989,p. 1877 - 1880

8
[ 19886-78-3 ]
[ 134455-70-2 ]

Reference： [1]Journal of Organic Chemistry,1991,vol. 56,p. 4208 - 4213

9
[ 19886-78-3 ]
[6-[1-Dimethylamino-meth-(E)-ylidene]-cyclohexa-2,4-dien-(Z)-ylidene]-methanol [ No CAS ]
C₁₀H₁₃NO [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1993,p. 598 - 599

10
[ 19886-78-3 ]
[ 88-89-1 ]
[ 101168-41-6 ]

Reference： [1]Journal of Organic Chemistry,1991,vol. 56,p. 4208 - 4213

11
[ 19886-78-3 ]
[ 624-49-7 ]
(1S,2R,3R,4S)-1-Dimethylamino-4-hydroxy-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid dimethyl ester [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1993,p. 598 - 599

12
[ 19886-78-3 ]
[ 623-91-6 ]
(1S,2R,3R,4S)-1-Dimethylamino-4-hydroxy-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid diethyl ester [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1993,p. 598 - 599

13
[ 6639-21-0 ]
[ 124-40-3 ]
[ 19886-78-3 ]

Reference： [1]Journal of Organic Chemistry,1961,vol. 26,p. 1371 - 1374

16
(+-)-tetra-N-methyl-1,2-dihydro-cyclobutabenzene-1r,2t(?)-diyldiamine [ No CAS ]
[ 19886-78-3 ]

Reference： [1]Journal of Organic Chemistry,1959,vol. 24,p. 579

17
[ 5326-34-1 ]
[ 19886-78-3 ]
[ 880880-15-9 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

18
[ 19886-78-3 ]
2-[(2-dimethylaminomethyl-phenyl)-methoxy-methyl]-5-methyl-phenylamine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

19
[ 19886-78-3 ]
(2-amino-4-methyl-phenyl)-(2-dimethylaminomethyl-phenyl)-methanone [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

20
[ 19886-78-3 ]
(2-amino-4-methyl-phenyl)-(2-dimethylaminomethyl-phenyl)-methanol [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

21
[ 19886-78-3 ]
[ 880880-16-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

22
[ 19886-78-3 ]
[ 880880-17-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1297 - 1300

23
[ 19886-78-3 ]
[ 112562-75-1 ]

Reference： [1]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 1953 - 1968

24
[ 19886-78-3 ]
[ 1460-59-9 ]

Reference： [1]Synthesis,1985,p. 698 - 699
[2]Synthesis,1985,p. 698 - 699

25
[ 19886-78-3 ]
[ 101681-22-5 ]

Reference： [1]Synthesis,1985,p. 698 - 699

26
[ 19886-78-3 ]
[ 101681-25-8 ]

Reference： [1]Synthesis,1985,p. 698 - 699
[2]Synthesis,1985,p. 698 - 699

27
[ 19886-78-3 ]
[ 101681-24-7 ]

Reference： [1]Synthesis,1985,p. 698 - 699

28
[ 19886-78-3 ]
[ 6196-39-0 ]

Reference： [1]Archiv der Pharmazie,1954,vol. 287,p. 613,616

29
[ 19886-78-3 ]
[ 101168-76-7 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 82,87

30
[ 19886-78-3 ]
[ 113135-25-4 ]

Reference： [1]Archiv der Pharmazie,1958,vol. 291,p. 82,87

31
[ 738570-45-1 ]
[ 19886-78-3 ]
2-(Dimethylaminomethyl)benzaldehyde 4-(oxazol-5-yl)phenylhydrazone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol;Heating / reflux;	Example 63 2-(Dimethylaminomethyl)benzaldehyde 4-(oxazol-5-yl)phenylhydrazone 2-(Dimethylaminomethyl)benzaldehyde (166 mg) was added to an ethanol solution (5 ml) of 4-(oxazol-5-yl)phenylhydrazine (163 mg), followed by heating overnight under reflux. The solvent was evaporated and the thus obtained residue was washed with diethyl ether to obtain the title compound (124 mg) as a yellow solid. 1H-NMR (400 MHz, CDCl3) delta: 2.25 (6H, s), 3.54 (2H, s), 7.16 (2H, d, J=8.5 Hz), 7.21 (1H, s), 7.22 (1H, t, J=7.8 Hz), 7.26 (1H, d, J=7.8 Hz), 7.33 (1H, t, J=7.8 Hz), 7.56 (2H, d, J=8.5 Hz), 7.85 (1H, s), 7.92 (1H, s), 8.06 (1H, d, J=7.8 Hz), 8.24 (1H, s). ESI-MS m/z: 321 (M+H)+.

Reference： [1]Patent: EP1612204,2006,A1 .Location in patent: Page/Page column 113

32
[ 53369-76-9 ]
[ 19886-78-3 ]

Yield	Reaction Conditions	Operation in experiment
		Reference Example 68 2-(Dimethylaminomethyl)benzaldehyde Diisobutylaluminum hydride (16.7 ml, 0.93 M hexane solution) was added dropwise to a THF solution (20 ml) of 2-(dimethylaminomethyl)benzonitrile (830 mg) at -78C, followed by stirring at the same temperature for 2 hours. Methanol (5.0 ml) was added dropwise to the reaction solution, and silica gel was subsequently added to the mixture, followed by stirring overnight at room temperature. The solvent was evaporated, the thus obtained residue was purified by silica gel column chromatography, and the fraction obtained from the elude of dichloromethane:methanol = 10:1 was concentrated under reduced pressure to obtain the title compound (166 mg) as a yellowish brown oil. 1H-NMR (400 MHz, CDCl3) delta: 2.25 (6H, s), 3.76 (2H, s), 7.39 (1H, t, J=7.8 Hz), 7.42 (1H, d, J=7.8 Hz), 7.51 (1H, t, J=7.8 Hz), 7.87 (1H, d, J=7.8 Hz), 10.37 (1H, s). ESI-MS m/z: 164 (M+H)+.

Reference： [1]Patent: EP1612204,2006,A1 .Location in patent: Page/Page column 42-43

33
[ 103-83-3 ]
[ 68-12-2 ]
[ 19886-78-3 ]

Reference： [1]ChemMedChem,2015,vol. 10,p. 2099 - 2110
[2]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 1078 - 1080

34
[ 5407-57-8 ]
[ 19886-78-3 ]
[ 1345001-24-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 1078 - 1080
[2]ChemMedChem,2015,vol. 10,p. 2099 - 2110

35
[ 19886-78-3 ]
[ 17876-09-4 ]

Reference： [1]ChemMedChem,2015,vol. 10,p. 2099 - 2110
[2]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 1078 - 1080

36
[ 6630-33-7 ]
[ 19886-78-3 ]

Reference： [1]Patent: US2014/243349,2014,A1

37
[ 1976-04-1 ]
[ 68-12-2 ]
[ 19886-78-3 ]

Yield	Reaction Conditions	Operation in experiment
25.5%		To a solution of 1-(2-bromophenyl)-N,N-dimethylmethanamine (LIII) in THF (25 mL) cooled to -78 C. under N2 was added a 2.5M solution of nBuLi in hexane (3.37 mL, 8.42 mmol). The reaction was stirred at -78 C. under N2 for 1.5 h before adding DMF (0.68 mL, 8.79 mmol). The reaction was stirred at -78 C. under N2 for 1 h and then warmed to room temperature. The solvent was removed under reduced pressure and purified on a silica column (100% CHCl3?10% MeOH/CHCl3) to produce 2-((dimethylamino)methyl)benzaldehyde (LIV) as a light yellow oil (305 mg, 1.87 mmol, 25.5% yield). 1H NMR (DMSO-d6, 500 MHz) delta ppm 2.14 (s, 6H), 3.72 (s, 2H), 7.42 (d, J=7.6 Hz, 1H), 7.45-7.48 (m, 1H), 7.57-7.59 (m, 1H), 7.78 (dd, J=1.2 Hz, J=7.6 Hz, 1H), 10.34 (s, 1H); ESIMS found C9H12BrN m/z 163.9 (M+H)

Reference： [1]Patent: US2014/243349,2014,A1 .Location in patent: Paragraph 1735; 1737

38
[ 19886-78-3 ]
[ 53369-77-0 ]