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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 19982-07-1 |
Formula : | C14H23NO |
M.W : | 221.34 |
SMILES Code : | CC(NC12CC3(C)CC(C2)(C)CC(C3)C1)=O |
MDL No. : | MFCD06656139 |
InChI Key : | WVIRSYCDAYUOMJ-UHFFFAOYSA-N |
Pubchem ID : | 5276209 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73.5% | With sulfuric acid; at 60 - 80℃; for 10h; | 10g <strong>[702-79-4]1,3-dimethyladamantane</strong>,36.8mL of acetonitrile is heated to 60 to 65 ,Slowly control the internal temperature not to drop 75mL concentrated sulfuric acid over 80 ,After the addition was completed, the reaction was carried out at 65 to 70 C for 10 h. The reaction mixture was quenched with ice water. After extraction with dichloromethane twice, the organic phases were combined, washed with organic phase, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure at 40 C The product has a yield of 73.5% and a purity of 99.7%. |
With sulfuric acid; at 65 - 80℃; for 10h;Product distribution / selectivity; | Example-1: Preparation of l-acetamido-3,5-dimethyI adamantane :A mixture of 1,3 -dimethyl adamantane (10 grams) and acetonitrile (36.8 ml) was heated to 60-65C. Sulphuric acid (75 ml) was slowly added to the above reaction mixture at below 80C. The reaction mixture was stirred for 10 hours at 65-70C. The reaction mixture was quenched with ice water. The reaction mixture was extracted with methylene chloride. The organic and aqueous layers were separated. The aqueous layer was extracted with methylene chloride and the organic layer was washed with water. The organic layer was dried with sodium sulphate. The methylene chloride from the organic layer was distilled off under reduced pressure at below 40C to get the title compound. Yield: 12.5 grams.Purity by GC: 99.47%; Example-2: Preparation of l-acetamido-3,5-dimethyl adamantane : A mixture of <strong>[702-79-4]1,3-dimethyl adamantane</strong> (10 grams) and acetonitrile (36.8 ml) was heated to 60-65C. Sulphuric acid (75 ml) was slowly added to the above reaction mixture at below 8O0C. The reaction mixture was stirred for 10 hours at 65-70C. The reaction mixture was quenched with ice water. The reaction mixture was extracted with toluene. The organic and aqueous layers were separated. The aqueous layer was extracted with toluene and the organic layer was washed with water. The organic layer was dried with sodium sulphate. The toluene from the organic layer was distilled off under reduced pressure at below 700C to get the title compound. Yield: 12.3 grams | |
Bromide (500 gm) was added to dimethyladamantane (100 gm) under stirring for 1 hour 30 minutes at 25 to 30C. The reaction mass maintained for 12 hours at 25 to 30C and the reaction mass was poured in water and methylene chloride under stirring at 5 to 10C. To the reaction mass was added sodium sulfite (20%, 1000 ml) at 0 to 5C and stirred for 30 minutes at 0 to 5C. The layers were separated and the organic layer was distilled off completely under vacuum at below 45C to obtain a residue. The residue was dissolved in acetonitrile (600 ml). The solution was cooled to 0 to 5C and then added concentrated sulfuric acid (300 ml) drop wise for 2 hours at 0 to 5C. Then, the contents were maintained for 14 hours at 25 to 30C and the reaction mass was poured into a mixture of water and methylene chloride under stirring at 0 to 5C. The layers were separated and the organic layer was distilled off completely under vacuum at below 45C to obtain a residue. To the residue was added water (500 ml) at 35 to 40C and stirred for 30 minutes at 50C. The reaction mass was cooled to 25 to 30C and maintained for 2 hours at 25 to 30C, filtered. The solid obtained was dried at 45C for 6 hours to obtain 130 gm of l-acetamido-3, 5 -dimethyl adamantane. |
12.8 g | With sulfuric acid; at 25 - 45℃; | Into <strong>[702-79-4]1,3-dimethyladamantane</strong> (10grams), sulphuric acid (56ml) added andslowly acetonitrile (37 .5rnl) was added at .25C-45C. The reaqtion mixturewas stirred at 25C-45C. The water was added in reaction mixture at 200C-300C. Then filtration followed by water washing to get ihe wet cake of titlecompound.Yield: 15.06grams wet cake (12.8grams on dried basis)Purity by GC: 99.50%Water content (moisture): 15%w jw |
59.9 g | With sulfuric acid; In tert-butyl alcohol; at 60℃; for 20h; | <strong>[702-79-4]1,3-dimethyl adamantane</strong> 50g three-necked flask 1L, acetonitrile 254 mL, was charged with t- butanol 28.2 g, heating at 60 C., 895 g sulfuric acid It was slowly added dropwise over a period of 2 hours. It was heated 18 hours at 60 C. After the dropwise addition. The reaction was poured into ice-cold water, and extracted with dichloromethane 700 mL. The organic layer was washed with water, and recrystallized from hexane 300mL After concentration under reduced pressure to give 1-acetamido-3,5-dimethyl adamantane 59.9 g. |
With sulfuric acid; In tert-butyl alcohol; at 50 - 70℃; for 18h; | 40 g of <strong>[702-79-4]1,3-dimethyl adamantane</strong> and 235 ml of sulfuric acid to give a layer of colorless liquid, ice water cooled to below 30 degrees; Stir under the drop of 95g acetonitrile, exothermic, control the internal temperature of the system up to no more than 75 degrees;After the dropwise addition, the controlled temperature was allowed to react at 50-70 C for 18 h and cooled to room temperature. Pour into 350ml ice water, stir; Extraction (100 ml X3) with dichloromethane, the organic phases were combined, dried and concentrated to give 46-48 g of a white solid powder. | |
With tert-butyl alcohol;sulfuric acid; at 50 - 80℃; for 6h; | A mixture of <strong>[702-79-4]1,3-dimethyladamantane</strong>, acetonitrile and t-butanol heat to 50 to 80C and add conc. sulphuric acid slowly within 3 hours. Maintain at 70 - 80C for 3 hours. The reaction mixture product was poured in to ice and extracted with dichloromethane and wash the dichloromethane layer with water and sodium bicarbonate solution. Wash with water and dry with sodium sulphate. Distilled the dichloromethane and concentrated of organic layer and add n-Hexane and reflux. Cool to 0C and filter the compound and wash with chilled n-hexane and dry the compound 1-acetamido-3,5-dimethyl adamantane. |
Tags: 1-Actamido-3,5-dimethyladmantane | Amines | Aliphatic Cyclic Hydrocarbons | Amides | Organic Building Blocks | 19982-07-1
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P101 | If medical advice is needed,have product container or label at hand. |
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Code | Phrase |
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P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
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P243 | Take precautionary measures against static discharge. |
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P270 | Do not eat, drink or smoke when using this product. |
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P231 + P232 | Handle under inert gas. Protect from moisture. |
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Code | Phrase |
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P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
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P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
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P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
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P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
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P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
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P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
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P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
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P502 | Refer to manufacturer/supplier for information on recovery/recycling |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
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H203 | Explosive; fire, blast or projection hazard |
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H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
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Health hazards | |
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H305 | May be harmful if swallowed and enters airways |
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H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
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H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
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H373 | May cause damage to organs through prolonged or repeated exposure |
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Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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