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Chemical Structure| 487-70-7 Chemical Structure| 487-70-7

Structure of Mesitaldehyde
CAS No.: 487-70-7

Chemical Structure| 487-70-7

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2,4,6-Trihydroxybenzaldehyde is an orally active NF-κB inhibitor with antitumor, anticancer cell proliferation, and anti-obesity biological activities.

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Product Citations

Product Citations

Lulu Xue ; Alex G. Hamilton ; Gan Zhao ; Zebin Xiao ; Rakan El-Mayta ; Xuexiang Han , et al.

Abstract: nanoparticles for delivering mRNA therapeutics hold immense promise for the treatment of a wide range of lung-associated diseases. However, the lack of effective methodologies capable of identifying the pulmonary delivery profile of chemically distinct libraries poses a significant obstacle to the advancement of mRNA therapeutics. Here we report the implementation of a barcoded high-throughput screening system as a means to identify the lung-targeting efficacy of cationic, degradable lipid-like materials. We combinatorially synthesize 180 cationic, degradable lipids which are initially screened in vitro. We then use barcoding technology to quantify how the selected 96 distinct nanoparticles deliver DNA barcodes in vivo. The top-performing nanoparticle formulation delivering Cas9-based genetic editors exhibits therapeutic potential for antiangiogenic cancer therapy within a lung in female mice. These data demonstrate that employing high-throughput barcoding technology as a screening tool for identifying nanoparticles with lung tropism holds potential for the development of next-generation extrahepatic delivery platforms.

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Product Details of Mesitaldehyde

CAS No. :487-70-7
Formula : C7H6O4
M.W : 154.12
SMILES Code : O=CC1=C(O)C=C(O)C=C1O
MDL No. :MFCD00003329
InChI Key :BTQAJGSMXCDDAJ-UHFFFAOYSA-N
Pubchem ID :68099

Safety of Mesitaldehyde

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.49mL

1.30mL

0.65mL

32.44mL

6.49mL

3.24mL

64.88mL

12.98mL

6.49mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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