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Chemical Structure| 3392-97-0

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Product Details of 2,6-Dimethoxybenzaldehyde

CAS No. :3392-97-0
Formula : C9H10O3
M.W : 166.17
SMILES Code : O=CC1=C(OC)C=CC=C1OC
MDL No. :MFCD00010862
InChI Key :WXSGQHKHUYTJNB-UHFFFAOYSA-N
Pubchem ID :96404

Safety of 2,6-Dimethoxybenzaldehyde

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of 2,6-Dimethoxybenzaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3392-97-0 ]

[ 3392-97-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 19012-02-3 ]
  • [ 3392-97-0 ]
  • [ 1344706-53-1 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In water; at 60℃; for 12h; General procedure: To a solution of N-methyl-3-acetylindol (1 mmol) and the benzaldehyde derivative (1 mmol) in methanol (10 ml) was added KOH (1 ml from a 50% solution in H2O). The mixture was heated at 60 C for 12 h then evaporated to dryness. The crude was dissolved in ethyl acetate (30 ml) then washed with HCl (1N, 10 ml) and H2O (10 ml), respectively. The organic layer was separated, dried over Na2SO4 and evaporated. The product was purified by chromatography column eluted with hexane:ethyl acetate (8:2) to yield the title compound as a yellow powder.
  • 2
  • [ 2040-05-3 ]
  • [ 3392-97-0 ]
  • [ 1355341-66-0 ]
  • 3
  • [ 6882-68-4 ]
  • [ 3392-97-0 ]
  • 14-(2,5-dimethoxyphenylmethylene)sophoridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% With sodium hydride; In tetrahydrofuran; mineral oil; at 37℃; for 13h;Reflux; General procedure: <strong>[6882-68-4]Sophoridin</strong>e(200 mg, 0.8 mmol) and 60% sodium hydride (806 mg, 20 mmol) into around-bottomed flask (50 mL) were resolved in anhydrous tetrahydrofuran (20mL). The solution was stirred and aldehyde (4 mmol) was added at 37 C andstirred for 1 h. The solution was then refluxed for 12 h. After cooling to roomtemperature, the mixture was pouredinto water (10 mL), acidified to pH=1~3 with 2N HCl and extracted with dichloromethane(3 × 40 mL). The aqueous phase was adjusted to pH=10~11 with 2N NaOH, and extracted with dichloromethane (3 × 40mL). The solvent was removed in vacuo, and the residue was purified by flashsilica gel column chromatography (petroleum ether/acetone, 10%) to afford 11-16.
  • 4
  • [ 3392-97-0 ]
  • [ 86361-55-9 ]
 

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