Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	530-78-9
Formula :	C₁₄H₁₀F₃NO₂
M.W :	281.23
SMILES Code :	O=C(O)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
Synonyms :	Flufenamic acid; CI-440; INF-1837
MDL No. :	MFCD00002422
InChI Key :	LPEPZBJOKDYZAD-UHFFFAOYSA-N
Pubchem ID :	3371

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H315-H319
Precautionary Statements:	P264-P270-P280-P301+P310+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P405-P501
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Pig ventricular myocytes	100 µM	>5 minutes	Investigate the effect of FFA on membrane ion currents, FFA caused an increase in currents with a reversal potential of +38 mV	Br J Pharmacol. 2010 Sep;161(2):416-29.
Mouse precursor osteoblasts (D1 cells)	1.0 and 2.0 mg/mL	21 days	Investigate the effect of FA on the proliferation and mineralization of D1 cells. Results showed that high concentrations of FA were not conducive to the proliferation of D1 cells but enhanced mineralization activity.	Pharmaceuticals (Basel). 2023 May 1;16(5):680.
Primary microglial cells	100 µM	24 hours	FA suppressed Syk activation, restored AMPK activity, and improved mitochondrial fission/fusion balance.	Aging Cell. 2022 May;21(5):e13623.
Primary microglial cells	200 µM	24 hours	FA inhibited microglial NLRP3 inflammasome activation by regulating Syk and AMPK, reducing ASC speck formation and IL-1β secretion.	Aging Cell. 2022 May;21(5):e13623.
Candida albicans SC5314 strain	≥8 mg/L	24 hours	Evaluate the preventive effect of FFA combined with FLU on Candida albicans biofilm formation, results showed that FFA ≥8 mg/L combined with FLU 32 mg/L could increase antifungal activity to 99%	Int J Antimicrob Agents. 2014 Jan;43(1):86-91.
Candida albicans mature biofilms	1024 mg/L	24 hours	Evaluate the therapeutic effect of FFA on mature Candida albicans biofilms, results showed that FFA concentrations of 1024 mg/L could reduce >85% of biofilm metabolic activity	Int J Antimicrob Agents. 2014 Jan;43(1):86-91.
Candida albicans biofilms	≥512 mg/L	24 hours	Evaluate the preventive effect of FFA on Candida albicans biofilm formation, results showed that FFA concentrations of ≥512 mg/L could prevent >80% of biofilm formation	Int J Antimicrob Agents. 2014 Jan;43(1):86-91.
Hippocampal pyramidal neurons	200 µM	30 ms	To investigate the effect of FFA on voltage-gated sodium currents, results showed that FFA inhibits ~50% of the sodium current with an IC50 of 189 μM.	J Physiol. 2010 Oct 15;588(Pt 20):3869-82.
Airway smooth muscle cells (ASMCs)	100 µM	330 seconds	Evaluate the relaxing effect of FFA on ASMCs, results showed FFA significantly reduced cell stiffness at 100 μM.	Theranostics. 2024 Feb 17;14(4):1744-1763.
Airway smooth muscle cells (ASMCs)	1 µM	330 seconds	Evaluate the relaxing effect of FFA on ASMCs, results showed FFA rapidly reduced cell stiffness at 1 μM.	Theranostics. 2024 Feb 17;14(4):1744-1763.
Rat supraoptic nucleus neuroendocrine cells	0.3 mM–5 mM	5–10 minutes	To examine the effects of flufenamic acid (FFA) on depolarizing afterpotentials (DAPs), results showed that FFA reversibly inhibited DAPs with an IC50 of 13.8 mM.	J Physiol. 2002 Dec 1;545(2):537-42.
Human adipose-derived stem cells (hASCs)	25, 50, 100, 200 µM	7 days	Low concentrations of FFA (25, 50, 100 μM) significantly enhanced osteogenic differentiation of hASCs, as evidenced by increased ALP activity and accelerated mineralization; 200 μM FFA inhibited osteogenic differentiation. The optimal concentration was 50 μM.	Stem Cell Res Ther. 2019 Jul 19;10(1):213.
Human bone marrow-derived mesenchymal stem cells (hBMMSCs)	25, 50, 100, 200 µM	7 days	Low concentrations of FFA (25, 50, 100 μM) significantly enhanced osteogenic differentiation of hBMMSCs, as evidenced by increased ALP activity and accelerated mineralization; 200 μM FFA inhibited osteogenic differentiation. The optimal concentration was 50 μM.	Stem Cell Res Ther. 2019 Jul 19;10(1):213.
HEK293 cells	2.49 µM (IC50)	72 hours	Assessed cytotoxicity, showing lower toxicity towards HEK293 cells, indicating selectivity for cancer cells over non-cancerous cells	Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202317940.
HMLER-shEcad cells	0.18 µM (IC50)	72 hours	Assessed cytotoxicity, showing sub-micromolar toxicity towards HMLER-shEcad cells, with 24-fold and 31-fold higher potency than salinomycin and cisplatin, respectively	Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202317940.
HMLER cells	0.27 µM (IC50)	72 hours	Assessed cytotoxicity, showing sub-micromolar toxicity towards HMLER cells	Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202317940.

Mice	4T1 metastatic triple-negative breast cancer model	Intraperitoneal injection	10 mg/kg	Three times a week for 14 days	Evaluated in vivo antitumour efficacy, showing significant inhibition of tumour growth and reduced lung metastasis without inducing significant systemic toxicity	Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202317940.
C57BL/6 mice and Thy1-GFP-M mice	T10 spinal cord contusion model	Intraperitoneal injection	12.5 mg/kg	Once daily for one week	FFA inhibited Trpm4 expression, reduced secondary hemorrhage and capillary fragmentation, and promoted angiogenesis; inhibited the expression of MMP-2 and MMP-9, attenuated BSCB disruption; decreased the activation of microglia/macrophages, reduced lesion size and cavity formation, protected motor neurons, and improved locomotor function.	Theranostics. 2018 Jul 30;8(15):4181-4198
C57BL/6J mice	Cardiac arrest/cardiopulmonary resuscitation model	Intraperitoneal injection	12.5 mg/kg	Once daily for one week	FFA improved survival and neurologic outcome after CA/CPR in mice, reduced neuropathological injuries, attenuated brain edema, lessened the leakage of IgG and Evans blue dye, restored tight junction protein expression, and promoted microglia/macrophages from the pro-inflammatory subtype toward the anti-inflammatory subtype.	J Neuroinflammation. 2022 Sep 1;19(1):214
BALB/c mice	Ovalbumin-induced asthmatic Mice model	Inhalation	2, 4, 8 μg	Single administration	Evaluate the effect of FFA on airway resistance in vivo, results showed FFA significantly reduced airway resistance at 8 μg.	Theranostics. 2024 Feb 17;14(4):1744-1763.
ADLPAPT mice	Alzheimer's disease model	Intraperitoneal injection	5 mg/kg	Once daily for 8 weeks	FA inhibited microglial NLRP3 inflammasome activation, significantly reducing amyloid plaques and phosphorylated tau pathology while improving cognitive function.	Aging Cell. 2022 May;21(5):e13623.
BALB/C nude mice	Heterotopic bone formation model	Subcutaneous implantation	50 μM	Single implantation, lasting 8 weeks	50 μM FFA promoted osteogenic differentiation of hBMMSCs in vivo, as evidenced by more newly formed bone and collagen organization.	Stem Cell Res Ther. 2019 Jul 19;10(1):213.

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CAS No.: 530-78-9

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CAS No.: 530-78-9

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed