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CAS No. :	23056-36-2
Formula :	C₅H₃ClN₂O₂
M.W :	158.54
SMILES Code :	ClC1=NC=CC(=C1)[N+](=O)[O-]
MDL No. :	MFCD00661454
InChI Key :	LIEPVGBDUYKPLC-UHFFFAOYSA-N
Pubchem ID :	735152

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302+H312+H332-H315-H319-H335
Precautionary Statements:	P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312

Yield	Reaction Conditions	Operation in experiment
95%		The mixture of diethyl malonate (80 ml, 0.5 mol) and sodium (2.76 g, 0.12 mol) was heated to 90 C in an oil bath and stirred for 1 h.After heating to 120 C for 45 min, it was cooled to room temperature.2-Chloro-4-nitropyridine (15.6 g, 0.1 mol) in toluene solution was added dropwise, and the reaction mixture was heated to 110 C for 1.5 h, cooled to room temperature and stirred for 15 h.The solvent was evaporated under reduced pressure, and then 6N hydrochloric acid (100 ml) was evaporated.The pH was made alkaline with a saturated sodium carbonate solution, extracted with ethyl acetate, combined with a base phase and dried over anhydrous sodium sulfate.Concentration by suction filtration gave 2-methyl-4-nitropyridine in a molar yield of 95%.
95%		The oil bath of the mixture of diethyl malonate (80 ml, 0.5 mol) and sodium (2.76 g, 0.12 mol) was warmed to 90 C. and stirred for 1 h. After warming to 120 C. and stirred for 45 min, it was cooled to room temperature.Add a solution of 2-chloro-4-nitropyridine (15.6g, 0.1mol) in toluene dropwise.The reaction solution was heated to 110 C for 1.5 h, cooled to room temperature and stirred for 15 h.The solvent was distilled off under reduced pressure, 6N hydrochloric acid (100ml) was added, the temperature was raised to reflux for 3.5h, and then cooled to room temperature.Adjust the pH to basic with saturated sodium carbonate solution, extract with ethyl acetate, combine the base phase,Dry over anhydrous sodium sulfate and concentrate by suction filtration to obtain 2-methyl-4-nitropyridine in a molar yield of 95%.

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P378
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire:
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P401
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P411 + P235	Keep cool.
Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 23056-36-2

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CAS No.: 23056-36-2

Alternative Products

Product Details of 2-Chloro-4-nitropyridine

Safety of 2-Chloro-4-nitropyridine

Application In Synthesis of 2-Chloro-4-nitropyridine

[ 23056-36-2 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed