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Chemical Structure| 42074-68-0 Chemical Structure| 42074-68-0
Chemical Structure| 42074-68-0

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Product Citations

Johan Storm Jørgensen ; Elnaz Harifi Mood ; Anne Sofie Holst Knap ; Simone Eidnes Nielsen ; Peter E. Nielsen ; Dorota Żabicka , et al.

Abstract: In view of the increased prevalence of antimicrobial resistance among human pathogens, antibiotics against multidrug-resistant (MDR) bacteria are in urgent demand. In particular, the rapidly emerging resistance to last-resort antibiotic colistin, used for severe Gram-negative MDR infections, is critical. Here, a series of polymyxins containing unnatural were explored, and some analogues exhibited excellent activity against Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. Hydrophobicity of the compounds within this series (as measured by retention in reversed-phase analytical HPLC) exhibited a discernible correlation with their antimicrobial activity. This trend was particularly pronounced for colistin-resistant pathogens. The most active compounds demonstrated competitive activity against a panel of Gram-negative pathogens, while exhibiting low in vitro cytotoxicity. Importantly, most of these hits also retained (or even had increased) potency against colistin-susceptible strains. These findings infer that fine-tuning hydrophobicity may enable the design of polymyxin analogues with favorable activity profiles.

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Product Details of 2-Chlorotrityl chloride

CAS No. :42074-68-0
Formula : C19H14Cl2
M.W : 313.22
SMILES Code : ClC1=CC=CC=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)Cl
MDL No. :MFCD00040399
InChI Key :JFLSOKIMYBSASW-UHFFFAOYSA-N
Pubchem ID :94524

Safety of 2-Chlorotrityl chloride

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H290-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of 2-Chlorotrityl chloride

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42074-68-0 ]

[ 42074-68-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2979-22-8 ]
  • [ 42074-68-0 ]
  • [ 196814-73-0 ]
  • (S)-2-(2-Benzoyl-phenylamino)-3-[4-(2-methoxy-2-phenyl-ethoxy)-phenyl]-propionic acid [ No CAS ]
  • 2
  • [ 42074-68-0 ]
  • [ 35661-51-9 ]
  • C19H14Cl2*C15H14N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20℃; 2-Chlorotrityl chloride resin (loading=0.6 mmol/g) (1 g) wasswelled in CH2Cl2/N,N-dimethylformamide (DMF)(10 mL/10 mL) at 0 °C. Fmoc-NH2NH2 (1.5 g, 10 eq.) andDIPEA (2 mL, 20 eq.) were added. The reaction was carriedout from 0 °C to r.t. overnight. Methanol (1 mL) was addedto quench the remaining 2-CTC resin. Then the resin waswashed with DMF, methanol and stored at 4 °C.
 

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