2-Pyridinecarbohydrazide | Pyridines

CAS No. :	1452-63-7
Formula :	C₆H₇N₃O
M.W :	137.14
SMILES Code :	O=C(NN)C1=NC=CC=C1
MDL No. :	MFCD00059782
InChI Key :	BAQLNPIEFOYKNB-UHFFFAOYSA-N
Pubchem ID :	255881

Safety of [ 1452-63-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P280-P305+P351+P338-P310

Computational Chemistry of [ 1452-63-7 ] Show Less

Physicochemical Properties

Num. heavy atoms	10
Num. arom. heavy atoms	6
Fraction Csp3	0.0
Num. rotatable bonds	2
Num. H-bond acceptors	3.0
Num. H-bond donors	2.0
Molar Refractivity	35.13
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	68.01 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.14
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	-0.83
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	-0.31
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	-0.47
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.27
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	-0.15

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-0.48
Solubility	45.5 mg/ml ; 0.332 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-0.12
Solubility	104.0 mg/ml ; 0.762 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-1.64
Solubility	3.17 mg/ml ; 0.0231 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-7.73 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	2.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.38

Application In Synthesis of [ 1452-63-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1452-63-7 ]

[ 1452-63-7 ] Synthesis Path-Downstream 1~5

1
[ 1452-63-7 ]
[ 13395-36-3 ]
[ 1447673-55-3 ]

References: [1]Chemistry of Heterocyclic Compounds,2013,vol. 49,p. 408 - 416.
Khim. Geterotsikl. Soedin.,2013,vol. 49,p. 440 - 449,10.

2
[ 1452-63-7 ]
[ 103854-64-4 ]
C₁₇H₁₄N₄O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	In ethanol; for 1h;Reflux;	Compound 2 (200 mg, 1.156 mmol) and picolinohydrazide (3) (190 mg, 1.387 mmol) were dissolved in 25 mL of absolute ethanol, the solution was heated to reflux and stirred for 1 h. After cooled to room temperature, the pale yellow precipitates formed was collected by filtration, which was washed with ethanol and dried under vacuum to give 1 in 74% yield. mp 182.5-183 C. 1H NMR (400 MHz, DMSO-d6) δ 12.69 (s, 1H), 8.77 (s, 1H), 8.72 (d,1H, J = 4.4 Hz), 8.33 (d, 1H, J = 4.8 Hz), 8.13 (t, 2H, J = 9.2Hz), 8.05 (t, 1H, J = 7.2 Hz), 7.67 (dd, 1H, J1 = 6.8 Hz, J2 =5.2 H), 7.54-7.48 (m, 2H), 7.20 (d, 1H, J = 6.8 Hz), 3.96 (s,3H). 13C NMR (100 MHz, DMSO-d6) δ 161.35, 155.58, 152.93, 149.78, 149.52, 149.02, 139.51, 138.55, 136.93, 129.40, 128.26, 127.67, 123.45, 119.82, 118.37, 109.36,56.02. HRMS (ESI+) cacld for C17H14N4O2Na: 329.1014, found: m/z 329.1017 [M+Na]+.

References: [1]Bulletin of the Korean Chemical Society,2013,vol. 34,p. 2256 - 2260.

3
[ 1452-63-7 ]
[ 87220-68-6 ]
2-(9-phenyl-9H-carbazole-3-yl)-5-(pyridin-2-yl)-1,3,4-oxadiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39.9%	In ethanol;Reflux;	9-Phenyl-9H-carbazole-3-carbaldehyde (2.71 g, 10 mmol) was added to the reaction flask and2-pyridinecarboxylic acid hydrazide (1.37 g, 10 mmol) followed by 120 mL of ethanol,The reaction was heated and stirred at reflux overnight. After cooling to room temperature,Slowly pour the reaction mixture into 500 mL of deionized water, and let it stand for 2 minutes after stirring for 10 minutes.Filter off and collect the white solid. The resulting white cake is in turn deionized water andEthanol was washed and placed in a vacuum oven at 50C for 24 hours.The dried intermediate product was placed in a single-mouth reaction flask and 70 mL of acetonitrile was added sequentially.30mL 1,4-dioxane and 150mL sodium hypochlorite solution,Stir for 30 min at room temperature. Pour the reaction slowly into 500mLDeionized water and extracted with dichloromethane (150 mL x 3).The organic phases were combined and washed with deionized water (200 mL x 3).The resulting organic phase was dried over anhydrous magnesium sulfate and concentrated.Column chromatography using ethyl acetate and petroleum ether as eluents gives the product L3 as a white solid.(1.55 g, 3.99 mmol), yield 39.9%.

References: [1]Patent: CN104163835,2017,B .Location in patent: Paragraph 0050; 0051.

4
[ 1452-63-7 ]
[ 7113-10-2 ]
2-phenyl-N′-picolinoylthiazole-4-carbohydrazide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 5881 - 5899.

5
[ 1452-63-7 ]
[ 39067-29-3 ]
N′-picolinoyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 5881 - 5899.

Historical Records

Technical Information

• Acyl Group Substitution • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

Related Functional Groups of
[ 1452-63-7 ]

Amides

A226558 [1452-77-3]

2-Pyridinecarboxamide

Similarity: 0.90

A303056 [956386-24-6]

6-Hydroxypicolinohydrazide

Similarity: 0.83

A161543 [1254073-41-0]

5-Fluoropicolinohydrazide

Similarity: 0.82

A152128 [50608-99-6]

3-Aminopicolinamide

Similarity: 0.82

A184798 [145255-19-2]

5-Aminopyridine-2-carboxamide

Similarity: 0.80

Hydrazides

A303056 [956386-24-6]

6-Hydroxypicolinohydrazide

Similarity: 0.83

A161543 [1254073-41-0]

5-Fluoropicolinohydrazide

Similarity: 0.82

A563218 [69583-00-2]

2-(Pyridin-4-yl)acetohydrazide

Similarity: 0.74

A166696 [39513-54-7]

Pyrimidine-4-carbohydrazide

Similarity: 0.73

Amines

A226558 [1452-77-3]

2-Pyridinecarboxamide

Similarity: 0.90

A303056 [956386-24-6]

6-Hydroxypicolinohydrazide

Similarity: 0.83

A161543 [1254073-41-0]

5-Fluoropicolinohydrazide

Similarity: 0.82

A152128 [50608-99-6]

3-Aminopicolinamide

Similarity: 0.82

A184798 [145255-19-2]

5-Aminopyridine-2-carboxamide

Similarity: 0.80

Hydrazines

A303056 [956386-24-6]

6-Hydroxypicolinohydrazide

Similarity: 0.83

A161543 [1254073-41-0]

5-Fluoropicolinohydrazide

Similarity: 0.82

A563218 [69583-00-2]

2-(Pyridin-4-yl)acetohydrazide

Similarity: 0.74

A166696 [39513-54-7]

Pyrimidine-4-carbohydrazide

Similarity: 0.73

Related Parent Nucleus of
[ 1452-63-7 ]

Pyridines

A226558 [1452-77-3]

2-Pyridinecarboxamide

Similarity: 0.90

A303056 [956386-24-6]

6-Hydroxypicolinohydrazide

Similarity: 0.83

A161543 [1254073-41-0]

5-Fluoropicolinohydrazide

Similarity: 0.82

A152128 [50608-99-6]

3-Aminopicolinamide

Similarity: 0.82

A184798 [145255-19-2]

5-Aminopyridine-2-carboxamide

Similarity: 0.80

Precautionary Statements-General
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Prevention
Code	Phrase
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Code	Phrase
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P320
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P321
P322
P330	Rinse mouth.
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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
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P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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P411
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P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
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P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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P501	Dispose of contents/container to ...
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1452-63-7

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