There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
USD 200+
Structure of 20074-80-0 * Storage: {[proInfo.prStorage]}
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Stage #1: With diisobutylaluminium hydride In toluene at -78℃; for 4 h; Stage #2: With hydrogenchloride; water In toluene at -78℃;
Example 53:Synthesis of 5-chloropentanaIO O *~Methyl 5-chloropentanoate 5-chloropentanalReaction:Material Amount mmol Mw equivA Methyl-5-Cl-pentanoate 3.5 mL 23.6 150.61 1B DIBALH 1 mol/L in 3O mL 30 (142.22) 1.27 toluene c toluene 13O mLProcedure:[0593] A solution of Methyl 5-chloropentanoate in toluene (130 mL) was cooled to -78 °C then DIBALH ( 30 mL, 30 mrnol) was added dropwise within 1 h. After three hours of additional stirring at -78°C the reaction was quenched by dropwise addition of 6 N hydrochloric acid (50 mL). The mixture was allowed to warm to rt. The layers were separated and then organic layer was washed with water (2 x), dried (Na2SC>4) and partially evaporated. The 5-chloropentanal was isolated as a clear colorless liquid (49percent by NMR) in toluene. The product solution was stored under argon at 4°C and used in the next step without further purification.
Reference:
[1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1962, # 3, p. 497[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1962, # 3, p. 538
[3] Organic and Biomolecular Chemistry, 2005, vol. 3, # 13, p. 2420 - 2430
[4] European Journal of Organic Chemistry, 2011, # 10, p. 1870 - 1879
[5] Organic Letters, 2011, vol. 13, # 15, p. 3988 - 3991
[6] Organic Letters, 2017, vol. 19, # 13, p. 3502 - 3504
[7] Patent: WO2008/137779, 2008, A2, . Location in patent: Page/Page column 271
2
[ 5259-98-3 ]
[ 20074-80-0 ]
Reference:
[1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 46, p. 10953 - 10962
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 3, p. 588 - 594
[3] Liebigs Annalen der Chemie, 1993, # 7, p. 771 - 776
[4] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9192 - 9202
[5] Synlett, 2000, # 9, p. 1336 - 1338
[6] Chemical Communications, 2004, # 16, p. 1830 - 1831
[7] Journal of the American Chemical Society, 2006, vol. 128, # 5, p. 1472 - 1473
[8] Synthesis, 2006, # 4, p. 687 - 691
[9] Patent: US2004/167167, 2004, A1, . Location in patent: Page/Page column 38
[10] Organic and Biomolecular Chemistry, 2007, vol. 5, # 22, p. 3614 - 3622
[11] Patent: EP1224173, 2005, B1, . Location in patent: Page/Page column 8
[12] RSC Advances, 2015, vol. 5, # 24, p. 18894 - 18908
[13] Journal of the American Chemical Society, 2015, vol. 137, # 30, p. 9523 - 9526
[14] RSC Advances, 2016, vol. 6, # 41, p. 35008 - 35013
3
[ 14267-92-6 ]
[ 5891-21-4 ]
[ 20074-80-0 ]
Reference:
[1] Angewandte Chemie - International Edition, 1998, vol. 37, # 20, p. 2867 - 2869
[2] Angewandte Chemie - International Edition, 1998, vol. 37, # 20, p. 2867 - 2869
4
[ 6280-87-1 ]
[ 20074-80-0 ]
Reference:
[1] Journal of Organic Chemistry, 1981, vol. 46, # 10, p. 2002 - 2009
5
[ 5259-98-3 ]
[ 78999-24-3 ]
[ 20074-80-0 ]
Reference:
[1] Patent: US5081287, 1992, A,
6
[ 96-41-3 ]
[ 20074-80-0 ]
Reference:
[1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988, vol. 37, p. 2289 - 2293[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988, # 11, p. 2538 - 2542
7
[ 19141-74-3 ]
[ 20074-80-0 ]
Reference:
[1] Tetrahedron Letters, 1971, p. 13 - 16
8
[ 96-41-3 ]
[ 110-62-3 ]
[ 20074-80-0 ]
[ 1119-46-6 ]
[ 120-92-3 ]
Reference:
[1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984, vol. 33, # 6, p. 1235 - 1239[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984, # 6, p. 1345 - 1348
9
[ 96-41-3 ]
[ 20074-80-0 ]
[ 1119-46-6 ]
[ 120-92-3 ]
Reference:
[1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984, vol. 33, # 6, p. 1235 - 1239[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984, # 6, p. 1345 - 1348
10
[ 113832-57-8 ]
[ 109-70-6 ]
[ 20074-80-0 ]
Reference:
[1] Journal of Organometallic Chemistry, 1976, vol. 122, p. 123 - 128
[2] Journal of Organic Chemistry, 1981, vol. 46, # 10, p. 2002 - 2009
11
[ 142-68-7 ]
[ 20074-80-0 ]
Reference:
[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9192 - 9202
12
[ 20395-28-2 ]
[ 20074-80-0 ]
Reference:
[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9192 - 9202
With diisobutylaluminium hydride In hexane; toluene at -78℃; for 3.5h;
With diisobutylaluminium hydride In toluene at -78℃; for 2h;
With diisobutylaluminium hydride In hexane; dichloromethane at -60℃; for 2.16667h; Inert atmosphere;
With diisobutylaluminium hydride In dichloromethane at -78℃; for 0.666667h;
49 %Spectr.
Stage #1: methyl 5-chloropentanoate With diisobutylaluminium hydride In toluene at -78℃; for 4h;
Stage #2: With hydrogenchloride; water In toluene at -78℃;
53
Example 53:Synthesis of 5-chloropentanaIO O *~Methyl 5-chloropentanoate 5-chloropentanalReaction:Material Amount mmol Mw equivA Methyl-5-Cl-pentanoate 3.5 mL 23.6 150.61 1B DIBALH 1 mol/L in 3O mL 30 (142.22) 1.27 toluene c toluene 13O mLProcedure:[0593] A solution of Methyl 5-chloropentanoate in toluene (130 mL) was cooled to -78 °C then DIBALH ( 30 mL, 30 mrnol) was added dropwise within 1 h. After three hours of additional stirring at -78°C the reaction was quenched by dropwise addition of 6 N hydrochloric acid (50 mL). The mixture was allowed to warm to rt. The layers were separated and then organic layer was washed with water (2 x), dried (Na2SC>4) and partially evaporated. The 5-chloropentanal was isolated as a clear colorless liquid (49% by NMR) in toluene. The product solution was stored under argon at 4°C and used in the next step without further purification.
(R)-5-chloro-1-((R)-2-methylene-2,3-dihydrobenzo[b]thiophen-3-yl)pentan-1-ol[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
90%
With chromium dichloride; manganese; zirconocene dichloride; 1,8-bis((S)-4-ethyl-4,5-dihydrooxazol-2-yl)-9H-carbazole; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dimethoxyethane at -10℃; for 24h; Inert atmosphere; Schlenk technique; stereoselective reaction;
7-chloro-2-(ethylsulfonyl)hepta-2-enenitrile[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
81%
With piperidine; acetic acid at 50℃; for 1h;
1 Production of 7-Chloro-2- (ethylsulfonyl) hepta-2-enenitrile
5-Chloropentanal 1.21 g (0.01 mol) and2- (Ethylsulfonyl) acetonitrile1.33 g (0.01 mol) was dissolved in 4 mL of acetic acid and heated to an internal temperature of 50 ° C. Under stirring, a solution of 0.17 g (2 mmol) of piperidine in 1 mL of acetic acid was added dropwise.Then, it heated to 50 degreeC for 1 hour. After allowing to cool, water was added to the reaction mixture, extracted with toluene, the organic layer was washed with water and then saturated brine, and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was subjected to silica gel column chromatography (ethyl acetate-hexane).Purification by 1: 2) gave 1.92 g (81%) of the title compound as a viscous oil.