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Chemical Structure| 2010-06-2 Chemical Structure| 2010-06-2
Chemical Structure| 2010-06-2

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Product Details of 2-Amino-4-phenylthiazole

CAS No. :2010-06-2
Formula : C9H8N2S
M.W : 176.24
SMILES Code : NC1=NC(C2=CC=CC=C2)=CS1
MDL No. :MFCD00039680
InChI Key :PYSJLPAOBIGQPK-UHFFFAOYSA-N
Pubchem ID :40302

Safety of 2-Amino-4-phenylthiazole

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H318-H335
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of 2-Amino-4-phenylthiazole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2010-06-2 ]

[ 2010-06-2 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 2010-06-2 ]
  • [ 526-08-9 ]
  • [ 97854-94-9 ]
  • 3
  • [ 2010-06-2 ]
  • [ 38107-10-7 ]
  • 4
  • [ 2010-06-2 ]
  • [ 53308-95-5 ]
  • tert-butyl N-[(1S)-1-[(4-phenylthiazol-2-yl)carbamoyl]butyl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20℃; for 8h;Inert atmosphere; To a mixture of (2S)-2-(tert-butoxycarbonylamino)pentanoic acid (200.0 mg, 920.55 pmol) in DCM (5.0 mL) was added EEDQ (310.42 mg, 1 .26 mmol) and 4-phenylthiazol-2-amine (147.49 mg, 836.86 pmol) in one portion at 20 °C under N2. The mixture was stirred at 20 °C for 8 hours. The reaction mixture was diluted with EtOAC (50.0 mL), and washed with citric acid (1 0percent) (50.0 mL * 3). The combined organic layers were washed with saturated brine (20.0 mL * 3), dried over Na2SC>4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (S1O2, Petroleum ether/Ethyl acetate=20/1 ) to give intermediate i-13a as colorless oil. LCMS (ESI) m/z: [M+H]+ = 376.3.
 

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