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Chemical Structure| 38107-10-7 Chemical Structure| 38107-10-7

Structure of 38107-10-7

Chemical Structure| 38107-10-7

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Product Details of [ 38107-10-7 ]

CAS No. :38107-10-7
Formula : C11H9NO2S
M.W : 219.26
SMILES Code : OC(=O)CC1=NC(=CS1)C1=CC=CC=C1
MDL No. :MFCD05177043
InChI Key :OLQHHTZTEVMZLC-UHFFFAOYSA-N
Pubchem ID :3926109

Safety of [ 38107-10-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 38107-10-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 38107-10-7 ]

[ 38107-10-7 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 339561-18-1 ]
  • [ 38107-10-7 ]
  • 4
  • [ 70-11-1 ]
  • sodium compound of fluorene-carboxylic acid-(9)-ethyl ester [ No CAS ]
  • [ 38107-10-7 ]
  • 5
  • [ 6094-68-4 ]
  • [ 38107-10-7 ]
  • 6
  • [ 2010-06-2 ]
  • [ 38107-10-7 ]
  • 7
  • [ 41381-89-9 ]
  • [ 38107-10-7 ]
YieldReaction ConditionsOperation in experiment
54% To a solution of Compound 18 (130 mg, 0.649 mmol) in EtOH (1.5 ml) was added 5 M NaOH solution (0.389 ml, 1.947 mmol). It was heated under reflux for 1 hour, diluted with 1M HCl aqueous solution (5 ml), and extracted with chloroform (10 ml) five times. The organic layer was dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified with silicagel chromatography (CHCl3: MeOH : AcOH = 10 : 1 : 0.1) to give Compound 19 (77.2 mg, 54 %) as brown oil. 1H-NMR(DMSO-d6): delta(ppm) 4.13 (s, 2H), 7.30-7.37 (m, 1H), 7.39-7.47 (m, 2H), 7.90-7.97 (m, 2H), 8.04 (s, 1H), 12.81 (brs, 1H)
  • 8
  • [ 1826-23-9 ]
  • [ 38107-10-7 ]
  • 9
  • [ 38107-10-7 ]
  • [ 1221931-26-5 ]
  • [ 1221931-52-7 ]
YieldReaction ConditionsOperation in experiment
55% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20.0℃; for 12.0h; To a solution of Compound 19 (60 mg, 0.274 mmol) in DMF (1 ml) were added triethylamine (0.19 ml, 1.368 mmol), WSCD-HCl (79 mg, 0.410 mmol), HOBt (56 mg, 0.410 mmol) and tert-butyl 3-(aminomethyl) benzoate hydrochloride (133 mg, 0.547 mmol). It was stirred at room temperature for 12 hours. It was diluted with 1M HCl aqueous solution (2.0 ml) and extracted with ethyl acetate (10 ml). The oil layer was washed with H2O (5 ml) and brine (5 ml), respectively and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified with silicagel chromatography (n-hexane : ethyl acetate = 1 : 1) to give Compound 20 (61.4 mg, 55 %) as yellow amorphous. 1H-NMR (DMSO-d6) delta: 1.53 (s, 9H), 4.05 (s, 2H) 4.40 (d, J=5.6 Hz, 2H), 7.30-7.37 (m, 1H), 7.39-7.49 (m, 3H), 7.55 (d, J=7.6 Hz, 1H), 7.76-7.85 (m, 2H), 7.93 (d, J=7.6 Hz, 2H), 8.00 (s, 1H), 8.87 (t, J=5.6 Hz, 1H).
  • 10
  • [ 38107-10-7 ]
  • [ 1221918-42-8 ]
 

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