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Chemical Structure| 201811-58-7 Chemical Structure| 201811-58-7

Structure of 201811-58-7

Chemical Structure| 201811-58-7

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Product Details of [ 201811-58-7 ]

CAS No. :201811-58-7
Formula : C11H14ClNO3
M.W : 243.69
SMILES Code : O=C(OC(C)(C)C)NC1=CC=C(O)C=C1Cl

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Application In Synthesis of [ 201811-58-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 201811-58-7 ]

[ 201811-58-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 201811-58-7 ]
  • [ 417721-36-9 ]
  • tert-butyl 4-(6-carbamoyl-7-methoxyquinolin-4-oxy)-2-chlorophenylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
93.9% With caesium carbonate; In dimethyl sulfoxide; at 90℃; for 8h; To 1000 ml of dimethylsulfoxide was added 87.0 g of <strong>[417721-36-9]7-methoxy-4-chloroquinoline-6-carboxamide</strong> (C), 100.0 g of tert-butyl (2-chloro-4-hydroxy-phenyl) B) and 334.0 g of cesium carbonate were added and stirred at 90 ° C for 8 hours.The reaction solution was lowered to room temperature, and the reaction solution was poured into 3000 ml of water, stirred for 30 minutes, filtered and dried to obtain 154.0 g of the title compound (D).(Yield 93.9percent).
  • 2
  • [ 201811-58-7 ]
  • [ 417721-36-9 ]
  • C23H23ClN2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
93.9% With tetrabutylammomium bromide; potassium carbonate; In dimethyl sulfoxide; at 90℃; for 8h; 6.1) Adding compound VI (100.0 g), compound V (87 g), to vessel F,1000 ml of dimethylsulfoxide (DMSO), potassium carbonate (138.2 g) and tetrabutylammonium bromide (65.8 g) were dissolved to give a mixture O; 6.2) The mixture O was stirred at 90°C for 8 hours, and then The stirred mixture O was poured into 3000ml of water for stirring, filtration, drying to obtain 154.0g of compound VII (yield 93.9percent)
 

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