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Chemical Structure| 201990-16-1 Chemical Structure| 201990-16-1

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Chemical Structure| 201990-16-1

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Product Details of [ 201990-16-1 ]

CAS No. :201990-16-1
Formula : C12H12INO3
M.W : 345.13
SMILES Code : O=C1N(CCOCCI)C(C2=C1C=CC=C2)=O

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Application In Synthesis of [ 201990-16-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 201990-16-1 ]

[ 201990-16-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 201990-16-1 ]
  • [ 309947-86-2 ]
  • [ 1408059-07-3 ]
YieldReaction ConditionsOperation in experiment
61% To a solution of protected adenine 30 (295 mg, 0.88 mmol) in DMF (10 mL) was added NaH (60% in mineral oil, 42 mg, 1.05 mmol). The reaction mixture was stirred at 70 C for one hour and then compound 29a (364 mg, 1.05 mmol) was added and the reaction mixture was stirred for 4 h at 70 C. After addition of water (20 mL) and EtOAc (30 mL) and decantation, the aqueous phase was extracted with EtOAc (2 * 30 mL) and the organic phase was dried over Na2SO4. After filtration and removal of the solvents under reduced pressure, the residue was purified by flash chromatography (cyclohexane/AcOEt, 30:70) to afford compound 31a (298 mg, 61%) as a colorless oil. 1H NMR (CDCl3) delta: 8.83 (s, 1H, H-2), 8.38 (s, 1H, H-8), 7.86 (m, 2H, 2 * H-phenyl), 7.72 (m, 2H, 2 * H-phenyl), 4.46 (2H, t, J = 5.0 Hz, CH2), 3.88 (2H, t, J = 5.4 Hz, CH2), 3.82 (2H, t, J = 4.8 Hz, CH2), 3.68 (2H, t, J = 5.3 Hz, CH2), 1.46 (s, 18H, C(CH3)3) ppm; 13C NMR (CDCl3) delta: 168.32 (C), 153.29 (C), 151.92 (CH), 150.59 (C), 150.05 (C), 146.11 (CH), 134.20 (CH), 132.04 (C), 128.24 (C), 123.51 (CH), 83.86 (C), 68.50 (CH2), 43.93 (CH2), 37.25 (CH2), 29.78 (CH2), 27.90 (CH3).
 

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