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[ CAS No. 202197-78-2 ] {[proInfo.proName]}

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Chemical Structure| 202197-78-2
Chemical Structure| 202197-78-2
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Product Details of [ 202197-78-2 ]

CAS No. :202197-78-2 MDL No. :MFCD08276179
Formula : C8H4ClIN2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 290.49 Pubchem ID :-
Synonyms :

Safety of [ 202197-78-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 202197-78-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202197-78-2 ]

[ 202197-78-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 20776-54-9 ]
  • [ 202197-78-2 ]
  • 2
  • [ 202197-77-1 ]
  • [ 202197-78-2 ]
YieldReaction ConditionsOperation in experiment
0.43 g With trichlorophosphate for 2h; Inert atmosphere; Reflux; 1.b (b)
Preparation of 4-Chloro-7-iodoquinazoline
7-Iodoquinazolin-4-one (0.46 g) was treated with phosphorous oxychloride (5 ml) at reflux under nitrogen for 2 hours. The mixture was cooled, evaporated and partitioned between saturated aqueous sodium carbonate and ethyl acetate. The organic phase was dried and concentrated in vacuo to give the title compound (0.43 g); m/z (M+1+) 291.
3 g With trichlorophosphate at 110℃; for 3h; Inert atmosphere; 1 Add 4-hydroxy-7-iodoquinazoline (5g, 18.4mmol) to 30ml phosphorus oxychloride,Under the protection of nitrogen, it was heated to 110°C and reacted for 3 hours.The reaction mixture was cooled to room temperature, and excess phosphorus oxychloride was removed by distillation under reduced pressure.Pour the residue into ice water and stir vigorously,It was basified with 2N sodium hydroxide aqueous solution to pH=9-10, and extracted with dichloromethane.The organic layer was dried with anhydrous sodium sulfate,Concentrate under reduced pressure to obtain 4-chloro-7-iodo-6-methoxyquinazoline (I-4, 3.0 g, yield 73%),The product is a yellow solid.
  • 3
  • [ 202197-78-2 ]
  • [ 1010422-58-8 ]
  • N-(5-ethynyl-2-fluorophenyl)-7-iodoquinazolin-4-amine [ No CAS ]
Reference: [1]ChemMedChem,2019
  • 4
  • [ 202197-78-2 ]
  • [ 77123-60-5 ]
  • N-(3-ethynyl-4-fluorophenyl)-7-iodoquinazolin-4-amine [ No CAS ]
Reference: [1]ChemMedChem,2019
  • 5
  • [ 116529-62-5 ]
  • [ 202197-78-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: tin(II) chloride dihdyrate / ethyl acetate / 20 °C 2: 2-methoxy-ethanol / 130 °C / Inert atmosphere 3: trichlorophosphate / 3 h / 110 °C / Inert atmosphere
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