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Chemical Structure| 20328-15-8 Chemical Structure| 20328-15-8

Structure of 20328-15-8

Chemical Structure| 20328-15-8

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Product Details of [ 20328-15-8 ]

CAS No. :20328-15-8
Formula : C7H9NO3
M.W : 155.15
SMILES Code : O=C(C1=CON=C1C)OCC
MDL No. :MFCD01075736

Safety of [ 20328-15-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 20328-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20328-15-8 ]

[ 20328-15-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 134653-70-6 ]
  • [ 20328-15-8 ]
  • [ 51135-73-0 ]
  • 2
  • [ 123-75-1 ]
  • [ 79-24-3 ]
  • [ 65651-80-1 ]
  • [ 103-72-0 ]
  • [ 623-47-2 ]
  • [ 20328-15-8 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In toluene; acetonitrile; a. 3-Methyl-4-[4-(trifluoromethyl)phenyl-aminocarbonyl]isoxazole. Ethyl propiolate (2.8 g) and pyrrolidine (1.4 g) in 5 mL of acetonitrile are mixed at room temperature for 1 hour, the solvent evaporated and the ethyl 3-pyrrolidin-1-acrylate used as isolated or distilled under vacuum. Triethylamine (0.25 mL) is added to a mixture of 1.8 g of ethyl 3-pyrrolidin-1-acrylate, 0.9 g of nitroethane and 2.5 g of phenyl isothiocyanate in 10 mL of toluene at room temperature and stirred overnight. The mixture is then refluxed for 0.5 hour, cooled, and the diphenylurea removed by filtration. The mixture is washed with water and brine, dried over anhydrous sodium sulfate, and evaporated to dryness under vacuum to give 1.4 g of ethyl 3-methyl-4-isoxazolecarboxylate. (Stork, G., McMurry, J. C., J. Am. Chem. Soc. 89, 5461,1967).
 

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