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[ CAS No. 20352-84-5 ] {[proInfo.proName]}

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Product Details of [ 20352-84-5 ]

CAS No. :	20352-84-5	MDL No. :	MFCD00126957
Formula :	C₇H₄ClN₃O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XVYNBLCPQVDRCH-UHFFFAOYSA-N
M.W :	197.58	Pubchem ID :	88504
Synonyms :

Safety of [ 20352-84-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H312-H317-H319-H332	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 20352-84-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 20352-84-5 ]
Downstream synthetic route of [ 20352-84-5 ]

[ 20352-84-5 ] Synthesis Path-Upstream 1~2

1
[ 20352-84-5 ]
[ 34662-30-1 ]

Reference： [1] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1518 - 1521
[2] Patent: US2008/188450, 2008, A1, . Location in patent: Page/Page column 14

2
[ 20352-84-5 ]
[ 34662-36-7 ]

Reference： [1] Patent: US2008/188450, 2008, A1,

[ 20352-84-5 ] Synthesis Path-Downstream 1~21

1
[ 20352-84-5 ]
[ 6375-46-8 ]
[ 2679-71-2 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sulfuric acid; aminosulfonic acid; sodium nitrite 1) 2 h, r.t.; 2) water, 6 h; Yield given. Multistep reaction;

Reference： [1]Thiel, W.; Mayer, R.; Jauer, E.-A.; Modrow, H.; Dost, H. [Journal fur praktische Chemie (Leipzig 1954), 1986, vol. 328, # 4, p. 497 - 514]

2
[ 20352-84-5 ]
[ 82997-64-6 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrogenchloride; zinc In tetrahydrofuran; water for 2h;	Aqueous hydrochloric acid (12 M, 5.3 mL) was added slowly to a mixture of zinc dust (2.01 g) and 2-amino-3-chloro-5-nitro-benzonitrile (0.50 g) in tetrahydrofuran (40 mL). The reaction mixture was stirred for 2 hours, neutralized with saturated aqueous sodium carbonate (50 mL), and extracted with ethyl acetate (3x 50 mL). The combined organic phases were dried over sodium sulfate and concentrated in vacuo to furnish 0.42 g (99% yield) of the title compound as a red solid.'H NMR (500 MHz, DMSO-d6): 4.89 (s, 2H), 5.13 (s, 2H), 6.64 (d, 1H), 6.89 (d, 1H).
76%	With hydrogenchloride; tin(ll) chloride at 45 - 50℃; for 1h;
	With hydrogen; hydrazine hydrate In ethanol at 40℃; for 4h; Autoclave; chemoselective reaction;

	With hydrazine hydrate In ethanol at 30℃; for 1.33333h; Autoclave; chemoselective reaction;	2.4. Catalytic reduction of nitro aromatics General procedure: The catalytic reduction of nitro aromatics was conducted in a 25 mlTelfon-lined stainless steel autoclave with magnetic stirring. In a typicalprocess, 6 mmol nitroarene, and desired amounts of reducing agent andsolvents were introduced in the reactor. The autoclave was transferredinto a water bath at the set temperature with an accuracy of better than0.2 °C for ∼0.5 h. Then, 10 mg catalyst was added into the reactionmixture and started the reduction at a stirring rate of 450 rpm. After thereaction, the catalyst was rapidly separated by ltration. n-Decane(500 μL) as standard was added into the ltrate and was dried withanhydrous Na 2 SO 4 . The products were analyzed by gas chromato-graphy-mass spectrometry (GC-MS) (Shimadzu GCMS-QP2010 Plus)and GC (Varian CP-3800) with a capillary column (column VF-1 ms,15 m, 0.25 mm, 0.25 μm) and a ame ionization detector (FID).
	With hydrogen In ethanol at 120℃; for 9h; Autoclave;	General procedure: The chemoselective hydrogenation of nitro aromatics with H2 as the hydrogen donor was carried out in a 100 mL stainless-steel autoclave with an external stirring and temperature controller. In a typical experiment, 10 mmol of nitro aromatics, 100 mg of catalysts and 10 mL of ethanol were introduced into the autoclave. Before starting the reaction, the autoclave was purged three times with 5 bar of hydrogen to remove the air, and pressurized to 2 MPa H2, followed by heating to 120 °C. The stirring speed is kept at 800 rpm. After a period of reaction, the autoclave was cooled down to room temperature and the remaining H2 was carefully released. The liquid solution was separated from the reaction mixture by filtration for further analysis.

Reference： [1]Current Patent Assignee: H. LUNDBECK A/S - WO2005/87754, 2005, A1 Location in patent: Page/Page column 42
[2]Shand, Charles A.; Thomson, Ronald H.; Greenhalgh, Colin W. [Journal of Chemical Research, Miniprint, 1982, # 6, p. 1601 - 1617]
[3]Wei, Ning; Zou, Xiujing; Huang, Haigen; Wang, Xueguang; Ding, Weizhong; Lu, Xionggang [European Journal of Organic Chemistry, 2018, vol. 2018, # 2, p. 209 - 214]
[4]Huang, Haigen; Liang, Xiangcheng; Wang, Xueguang; Sheng, Yao; Chen, Chenju; Zou, Xiujing; Lu, Xionggang [Applied Catalysis A: General, 2018, vol. 559, p. 127 - 137]
[5]Lu, Xionggang; Ren, Jiaan; Sheng, Yao; Wang, Xueguang; Wu, Baoqin; Zou, Xiujing [Journal of Alloys and Compounds, 2022, vol. 897]

3
[ 99-30-9 ]
[ 544-92-3 ]
[ 20352-84-5 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine

Reference： [1]Johri; Varshney [Journal of the Indian Chemical Society, 1996, vol. 73, # 11, p. 629 - 630]

4
[ 20352-84-5 ]
[ 148-87-8 ]
2'-chloro-6'-cyano-4'-nitro-4-(N-β-cyanoethyl-N-ethyl)amino-1,1'-azobenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; sodium acetate; acetic acid; sodium nitrite 1.) 10 deg C, 2.) 5 deg C, overnight; Yield given. Multistep reaction;

Reference： [1]Johri; Varshney [Journal of the Indian Chemical Society, 1996, vol. 73, # 11, p. 629 - 630]

Yield	Reaction Conditions	Operation in experiment
	Rk.mit NO(HSO4), H2SO4 (Kinetik): Geschw.-Konst.; Aktivierungsenergie;

Yield	Reaction Conditions	Operation in experiment
	3-Chlor-5-nitro-anthranilamid;
		Examples of Amines Useful in the Present Invention 2-chloro-4,6-dinitroaniline 2-bromo-4,6-dinitroaniline 2-chloro-6-cyano-4-nitroaniline 2-bromo-6-cyano-4-nitroaniline 2,6-dicyano-4-nitroaniline 2-cyano-4,6-dinitroaniline
	Triphenylphosphin-2-brom-4-nitro-6-chlorphenylimin-1, 1) CuCN/N-Methylpyrrolidon, Δ, 2) HCl (10percent), Δ;

7
[ 20352-84-5 ]
C₁₉H₁₂ClN₃S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 76 percent / SnCl₂*2H₂O, conc. HCl / 1 h / 45 - 50 °C 2: 46 percent / pyridine / CH₂Cl₂

Reference： [1]Shand, Charles A.; Thomson, Ronald H.; Greenhalgh, Colin W. [Journal of Chemical Research, Miniprint, 1982, # 6, p. 1601 - 1617]

8
[ 21414-23-3 ]
[ 20352-84-5 ]
[5-(2-Amino-3-chlor-5-nitrophenyl)tetrazolato]carbonylbis(triphenylphosphan)iridium(I)*0.5CH₂Cl₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	In tetrahydrofuran in N2, stirring for 2 d; filtration, graduation of the soln., addn. of ether, recrystn. twice from CH2Cl2/ether, drying for several hs with high vac., elem.anal.;

Reference： [1]Erbe, Juergen; Beck, Wolfgang [Chemische Berichte, 1983, vol. 116, # 12, p. 3867 - 3876]

9
[ 30854-89-8 ]
[ 20352-84-5 ]
[ 88178-10-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	In tetrahydrofuran in N2, stirring at room temp. for 3 d; graduation, addn. of ether, recrystn. twice from CH2Cl2/ether, washing with ether, drying in high vac., elem.anal.;

Reference： [1]Erbe, Juergen; Beck, Wolfgang [Chemische Berichte, 1983, vol. 116, # 12, p. 3867 - 3876]

10
[ 20352-84-5 ]
[ 34662-30-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; sodium nitrite; In water; isopropyl alcohol; at 0 - 40℃; for 3h;	Concentrated H2SO4 (440 mL) was added slowly to crushed ice (1200 g) and 2-amino-3-chloro-5-nitrobenzonitrile (43.8 g) was suspended in the resulting H2SO4 solution. After addition of 2-propanol (1600 mL), the mixture was heated to 40 C. internal temperature with vigorous stirring. A solution of NaNO2 (66.0 g) in water (100 mL) was added dropwise. After completion of addition, the mixture was kept at 40 C. for an additional 3 h, then cooled to ambient temperature and extracted with CH2Cl2. The organic extract was washed sequentially with water, 0.1 N NaOH, water, and brine, and then dried over MgSO4, filtered through a pad of silica gel, and evaporated to yield the crude product as a yellow solid. Chromatography on silica gel (20% EtOAc/hexanes) followed by crystallization from 2-propanol yielded the product as yellow crystals. 1H-NMR (CDCl3): delta 8.47 (1H, t, J=2.0 Hz), 8.43 (1H, dd, J=1.4, 2.0 Hz), 7.98 (1H, dd, J=1.4, 2.0 Hz). 13C-NMR (CDCl3): delta 148.8, 137.4, 137.0, 128.1, 125.3, 115.4, 115.3.

Reference： [1]Journal of Medicinal Chemistry,2009,vol. 52,p. 1518 - 1521
[2]Patent: US2008/188450,2008,A1 .Location in patent: Page/Page column 14

11
[ 20352-84-5 ]
[ 1192548-72-3 ]

Yield	Reaction Conditions	Operation in experiment
	With tert.-butylnitrite; copper(l) cyanide In acetonitrile at 0 - 65℃;	111 Reference Example 111 3-Chloro-5-nitrophthalonitrile To acetonitrile solution (150 mL) comprising 2-amino-3-chloro-5-nitrobenzonitrile (3.0 g, manufactured by Aldrich Company), copper (I) cyanide (2.04 g, manufactured by Aldrich Company) and tert-butyl nitrite (2.73 mL, manufactured by Kanto Chemical Co., Inc.) were added at 0° C. After stirring the mixture for one hour, the temperature was raised to room temperature and the mixture was stirred for 2 hours, followed by raising the temperature to 65° C. and stirring at the same temperature for 15 hours. Then, copper (I) cyanide (2.04 g) and tert-butyl nitrite (2.73 mL) were added again thereto and the mixture was stirred for 9 hours. Upon the completion of stirring, the reaction solution was poured over saturated brine, extracted with ethyl acetate, and the organic layer was dried over sodium sulfate. The solids were removed by filtration, and the filtrate was dried under reduced pressure and subjected to flash column chromatography (using 10/1 (v:v) hexane/ethyl acetate as an eluent) to obtain the title compound (299 mg). 1H-NMR (CDCl3): 8.62 (1H, dd, J=1.83), 8.55 (1H, dd, J=1.83).

Reference： [1]Current Patent Assignee: ASAHI KASEI CORPORATION - US2009/298894, 2009, A1 Location in patent: Page/Page column 92

12
[ 1222406-73-6 ]
[ 20352-84-5 ]
[ 1222406-76-9 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1-amino-2-cyano-4-nitro-6-chlorobenzene With nitrosylsulfuric acid; sulfuric acid In water at 20℃; Stage #2: 3-diallylaminophenoxyacetic acid methylester With sulfuric acid; aminosulfonic acid; acetic acid In water at 4 - 20℃;	I.2 14 g of sulfuric acid (97%) are added to 1 1.5 g of ice. After the solution has cooled down to 20 0C, 3.4 g of 2-amino-3-chlor-5-nitrobenzonitrile is added. Subsequently, 3.4 g of nitrosyl sulfuric acid (40% in sulfuric acid) are added while the reaction mixture is cooled. Then the mixture is stirred for two hours at 20 0C and cooled down to 5 0C before coupling. A solution of the coupling component is prepared by addition of 4.6 g of sulfuric acid and 4.5 g of 3-diallylaminophenoxyacetic acid methylester to 50 ml water. Afterwards, 9.3 g of acetic acid, 2.6 g of a solution (10 %) of sulfamic acid and 22 g of ice are added, followed by the addition of the solution of the diazonium salt. The temperature is held between 4 and 8 0C while adding 46 g of ice and afterwards the reaction mixture is allowed to grow warm to 20 0C. It is stirred for 22 hours at room temperature, filtered and washed until it becomes neutral. The wet filter cake (32g) is given to 57 g water. 137 mg of Surfynol 104E and acetic acid are added in an amount to adjust the pH value between 3 and 4. The mixture is stirred at 95 0C for six hours. Subsequently, the hot solution is filtered off and the filter cake is dried in vacuum. Yield: 5.8 g of the dye of formula (101 ); wavelength of the absorption maximum λmax = 558 nm

Reference： [1]Current Patent Assignee: HUNTSMAN CORP - WO2010/46192, 2010, A2 Location in patent: Page/Page column 9-10

13
[ 124-38-9 ]
[ 20352-84-5 ]
[ 1234465-39-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With 14.6 wtpercent amine functionalized MCM-41 In water at 150℃; for 18h; Green chemistry;

Reference： [1]Nale, Deepak B.; Rana, Surjyakanta; Parida, Kulamani; Bhanage, Bhalchandra M. [Catalysis science and technology, 2014, vol. 4, # 6, p. 1608 - 1614]

14
[ 20352-84-5 ]
2-bromo-3-chloro-5-nitrobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With isopentyl nitrate; copper(ll) bromide In acetonitrile at 65℃; for 2h;	Intermediate 168A: 2-bromo-3-chloro-5-nitrobenzonitrile To 2-Amino-3-chloro-5-nitrobenzonitrile (5.0 g, 25.3 mmol) and Copper (II) bromide (9.0 g, 38.0 mmol) in acetonitrile (200 mL) was added isopentyl nitrate (5.81 mL, 38.0 mmol). The reaction mixture was heated at 65 °C for two hours. After this time the reaction was allowed to cool to room temperature. 2N HCl solution (50 mL) was added to the reaction mixture and the organics were extracted with DCM (3 x 40 mL). The organics were then dried over MgS04, filtered and concentrated under reduced pressure. The crude material was purified by Biotage Isolera chromatography (silica gel, eluting with heptanes-EtOAc, 1 :0 to 0:1 ) to afford 6.3 g (83% yield) of the title compound as a yellow solid.1H NMR (250 MHz, DMSO-d6) δ [ppm] 8.74 (d, J = 2.1 Hz, 1 H), 8.81 (d, J = 2.1 Hz, 1 H).LCMS (Analytical Method A): Rt = 1.20 mins, no ionisation

Reference： [1]Current Patent Assignee: BAYER AG - WO2018/114783, 2018, A1 Location in patent: Page/Page column 155

15
[ 20352-84-5 ]
3-chloro-2-(6-ethoxypyridin-3-yl)-5-nitrobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: copper(ll) bromide; isopentyl nitrate / acetonitrile / 2 h / 65 °C 2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / 100 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: BAYER AG - WO2018/114783, 2018, A1

16
[ 20352-84-5 ]
5-[2-chloro-4-nitro-6-(1H-tetrazol-5-yl)phenyl]-2-ethoxypyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: copper(ll) bromide; isopentyl nitrate / acetonitrile / 2 h / 65 °C 2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / 100 °C / Inert atmosphere 3: trimethylsilylazide; di(n-butyl)tin oxide / para-xylene / 130 °C

Reference： [1]Current Patent Assignee: BAYER AG - WO2018/114783, 2018, A1

17
[ 20352-84-5 ]
3-chloro-4-(6-ethoxypyridin-3-yl)-5-(1H-tetrazol-5-yl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: copper(ll) bromide; isopentyl nitrate / acetonitrile / 2 h / 65 °C 2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / 100 °C / Inert atmosphere 3: trimethylsilylazide; di(n-butyl)tin oxide / para-xylene / 130 °C 4: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

Reference： [1]Current Patent Assignee: BAYER AG - WO2018/114783, 2018, A1

18
[ 20352-84-5 ]
[ 34662-36-7 ]

Reference： [1]Patent: US2008/188450,2008,A1

19
[ 20352-84-5 ]
3-amino-5-chlorobenzoic acid hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: sulfuric acid; sodium nitrite / water; isopropyl alcohol / 3 h / 0 - 40 °C 2: sulfuric acid; water / 2 h / 150 °C 3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 0.5 h / 1551.49 Torr

Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US2008/188450, 2008, A1

20
[ 20352-84-5 ]
C₁₁H₄Cl₂F₄N₂O [ No CAS ]
1-(2-chloro-4-fluorophenyl)-N-(2-chloro-6-cyano-4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine In dichloromethane Reflux;	3.2 General synthetic procedure for compounds 1-(2-chloro-4-fluorophenyl)-N-(2,4,6-trisubstitutedphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (12a-c) General procedure: A solution of 2,4,6-trisubstitutedphenylamine (10, 0.8 mmol) in pyridine (10 mL) was added to the flask containingt he crude acyl chloride 8 (0.8 mmol) which was prepared from the procedure described above, and the mixture was refluxed for 3-5 h. After cooling down, the mixture was poured into water (50 mL) and extracted with ethyl acetate (3× 15 mL). The extracts were combined and washed with hydrochloric acid (2 × 10 mL) and brine, successively. The organic phase was dried over anhydrous Na2SO4. After solvent removal, the residue was further purified by recrystallization from ethanol to afford the title compound 12(a-c) as a solid.

Reference： [1]Wang, Baolei; Wang, Hongxue; Liu, Hang; Xiong, Lixia; Yang, Na; Zhang, Yan; Li, Zhengming [Chinese Chemical Letters, 2020, vol. 31, # 3, p. 739 - 745]

21
[ 943982-60-3 ]
[ 20352-84-5 ]
3-bromo-N-(2-chloro-6-cyano-4-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine In dichloromethane Reflux;	3.2 General synthetic procedure for compounds 1-(2-chloro-4-fluorophenyl)-N-(2,4,6-trisubstitutedphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (12a-c) General procedure: A solution of 2,4,6-trisubstitutedphenylamine (10, 0.8 mmol) in pyridine (10 mL) was added to the flask containingt he crude acyl chloride 8 (0.8 mmol) which was prepared from the procedure described above, and the mixture was refluxed for 3-5 h. After cooling down, the mixture was poured into water (50 mL) and extracted with ethyl acetate (3× 15 mL). The extracts were combined and washed with hydrochloric acid (2 × 10 mL) and brine, successively. The organic phase was dried over anhydrous Na2SO4. After solvent removal, the residue was further purified by recrystallization from ethanol to afford the title compound 12(a-c) as a solid.

Reference： [1]Wang, Baolei; Wang, Hongxue; Liu, Hang; Xiong, Lixia; Yang, Na; Zhang, Yan; Li, Zhengming [Chinese Chemical Letters, 2020, vol. 31, # 3, p. 739 - 745]

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P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere