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EXAMPLE 1 [1H]-Isoindolin-1-one-3-carboxylic acid Ammonia gas was bubbled into a cooled (10°-15° C.) solution of 10 g (0.0666 mole) of phthalaldehydic acid in 100 ml of methanol for 10 minutes, and the solution allowed to stir at room temperature for one hour. To the stirred solution was added a solution of 3.26 g (0.0666 mole) of sodium cyanide in 100 ml of water over a 15 minute period. After stirring at room temperature for one hour, most of the methanol was removed in vacuo and the resulting yellow solution was treated dropwise with 80 ml of 6 N hydrochloric acid over a 10 minute period, producing a transient precipitate followed by redissolution. The solution was heated at 100° C. for 1.5 hours, producing a thick yellow precipitate. The mixture was cooled to room temperature, the yellow solid filtered and washed with water and acetone. The resulting solid was recrystallized from water, 4.14 g (34percent yield), m.p. 153°-154° C. The product displayed physical properties in complete agreement with those described in the literature, Darapsky, et al., J. Prakt. Chem., 146, 307 (1936).
Reference：
[1] Patent: US4730056, 1988, A,
2
[ 16859-59-9 ]
[ 143-33-9 ]
[ 20361-09-5 ]
Reference：
[1] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 877
EXAMPLE 1 [1H]-Isoindolin-1-one-3-carboxylic acid Ammonia gas was bubbled into a cooled (10-15 C.) solution of 10 g (0.0666 mole) of phthalaldehydic acid in 100 ml of methanol for 10 minutes, and the solution allowed to stir at room temperature for one hour. To the stirred solution was added a solution of 3.26 g (0.0666 mole) of sodium cyanide in 100 ml of water over a 15 minute period. After stirring at room temperature for one hour, most of the methanol was removed in vacuo and the resulting yellow solution was treated dropwise with 80 ml of 6 N hydrochloric acid over a 10 minute period, producing a transient precipitate followed by redissolution. The solution was heated at 100 C. for 1.5 hours, producing a thick yellow precipitate. The mixture was cooled to room temperature, the yellow solid filtered and washed with water and acetone. The resulting solid was recrystallized from water, 4.14 g (34% yield), m.p. 153-154 C. The product displayed physical properties in complete agreement with those described in the literature, Darapsky, et al., J. Prakt. Chem., 146, 307 (1936).
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