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CAS No. : | 203662-51-5 | MDL No. : | MFCD09910310 |
Formula : | C13H23NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | BWHACQPKDGMQIK-UHFFFAOYSA-N |
M.W : | 241.33 g/mol | Pubchem ID : | 21955339 |
Synonyms : |
|
Num. heavy atoms : | 17 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.77 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 71.74 |
TPSA : | 49.77 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.42 cm/s |
Log Po/w (iLOGP) : | 2.95 |
Log Po/w (XLOGP3) : | 1.91 |
Log Po/w (WLOGP) : | 1.94 |
Log Po/w (MLOGP) : | 1.6 |
Log Po/w (SILICOS-IT) : | 1.81 |
Consensus Log Po/w : | 2.04 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.21 |
Solubility : | 1.49 mg/ml ; 0.00617 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.58 |
Solubility : | 0.637 mg/ml ; 0.00264 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -1.77 |
Solubility : | 4.05 mg/ml ; 0.0168 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.49 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99.9% | With ammonium chloride; zinc In tetrahydrofuran; water at -10 - 40℃; | a, compound 1 ( 50g, 0.25mol) and zinc powder (49.2g, 0 . 75mol) tetrahydrofuran and ammonium chloride aqueous solution suspended (2/3,500 ml) in a mixed solution. - 10-10°C to control the temperature, to the reaction solution adding dropwisely compound 2 ( 109.3g, 0 . 90mol). The reaction slowly increase 15-40°C, to continue reaction 2-5 hours. TLC (petroleum ether/ethyl acetate = 2/1 volume ratio) display reaction is ended. The reaction solution with ethyl acetate (100mLx3). Combined with the phase, by sodium sulfate drying, filtering after concentration to obtain crude product is distilled under reduced pressure. The crude product by silica gel column (petroleum ether/ethyl acetate = 30/1 volume ratio to 10/1) to obtain colorless oily compound 3 ( 60g), yield 99.9percent. |
95% | Stage #1: With ammonium chloride; zinc In tetrahydrofuran at 10℃; Industry scale Stage #2: With sulfuric acid; water In tetrahydrofuranIndustry scale Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water; <i>tert</i>-butyl alcoholIndustry scale |
tert-butyl 4-allvl-4-hvdroxypiperidine-1-carboxvlate tert-butyl 4-oxopiperidine-i-carboxylate (1000 g, 5.02 mol) was dissolved in allylbromide (1080 ml_, 12.4 mol, 2.5 eq), THF (1000 ml_) and saturated ammonium chloride solution (5000 ml_). The reaction was cooled to 10 0C and zinc dust (650 g, 10 mol, 2 eq) was added portion wise. After addition the reaction mixture was stirred overnight. TLC was taken (heptane/EtOAc 7:1 ) and showed full conversion. The reaction mixture was diluted with water (5 L) and acidified with 10percent H2SO4 to pH~6. The reaction mixture was extracted with MTBE (3x). The organic layers were combined and extracted with saturated solution of NaHCO3, brine and evaporated to give tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate (1153 g, 95percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19.08% | at 0℃; for 3 h; Inert atmosphere | 1-Tert-butoxycarbonyl-4-piperidone (2.5 g, 12.55 mmol) was dissolved in anhydrous tetrahydrofuran (25 mL), allyl magnesium bromide (1M, 16.30 mL) was slowly added dropwise under nitrogen atmosphere at 0° C. over 1 h. The reaction was stirred for 2 h at 0° C. until the reaction was complete as monitored by TLC. The reaction mixture was quenched with saturated aqueous solution of ammonium chloride (80 mL), the reaction was allowed to warm to room temperature and extracted with ethyl acetate (100 mL). The organic phase was washed with saturated aqueous solution of sodium chloride (100 mL) once and dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under vacuum. The residue was purified with column chromatography (height: 100 mm, diameter: 50 mm, 100-200 silica gel, petroleum ether/ethyl acetate=4/1, 2/1) to afford 3-hydroxy-3-(1-tert-butoxycarbonyl-4-piperidyl)-1-propene (750.00 mg, 3.11 mmol, yield: 19.08percent) as a yellow liquid. 1H NMR (400 MHz, CHLOROFORM-d:) δ 5.93-5.83 (m, 1H), 5.27-5.14 (m, 2H), 3.83 (br. s., 2H), 3.18 (br. s., 2H), 2.25 (d, J=7.5 Hz, 2H), 1.61-1.50 (m, 4H), 1.48 (s, 9H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With zinc In tetrahydrofuran | Step A 1-(t-Butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine A dry round bottom flask was purged with nitrogen and charged with 1-t-butoxycarbonyl-4-piperidinone (20 g, 100 mmol), titanocene dichloride (1.2 g, 5 mmol) and zinc dust (7.8 g, 120 mmol) in 100 mL dry THF. Allyl bromide (11.3 mL, 130 mmol) was added and the mixture was stirred for 5 h at rt. The mixture was diluted with 700 mL EtOAc, washed with 2.0 M HCl (2*200 ML), 100 mL of sat'd NaCl, dried over MgSO4 and concentrated. Flash chromatography (650 g silica, 10/1 CH2Cl2/Et2O eluant) afforded 10.9 g (45percent) of the title compound: 1H NMR (300 MHz) δ 1.4-1.6 (13H), 2.2-2.25 (d, 2H), 3.1-3.2 (m, 2H), 3.75-3.85 (m, 2H), 5.1-5.25 (m, 2H), 5.78-5.92 (m, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35% | Stage #1: With sodium periodate In water; <i>tert</i>-butyl alcohol at 50℃; for 0.5 h; Industry scale Stage #2: With sodium disulfite In water; <i>tert</i>-butyl alcohol at 20 - 50℃; for 59 h; Industry scale |
tert-butyl (3RS)-3-hydroxy-1-oxa-8-azaspiro[4.5ldecane-8-carboxylate tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate (1153 g, 4.8 mol) was dissolved in tert-butanol (10 L) and water (4 L). To the solution sodium periodate (1124 g, 5.3 mol, 1.1 eq) was added and the mixture was stirred at 50 0C for 30 minutes. At 50 0C a solution of Na2S2O5 (1007 g, 5.3 mol, 1.1 eq) in water (4.2 L) was added dropwise over 4 hours to the solution. After addition the reaction mixture was stirred for 7 hours at 50 0C and another 48 hours at RT. The mixture was transferred to an extraction vessel and the organic layer was separated from the aqueous layer. The aqueous layer was extracted (3x) with ethyl acetate. The organic layers were combined and washed with a saturated solution of Na2S2O3 (3x) to give a colorless solution. The solution was washed with brine and evaporated to give crude product (987 g, 80percent). The crude product was purified by flash chromatography (10-80percent EtOAc/Heptane) to give the title compound (287 g, 35percent). m/z 158 (MH+ minus Boc). |
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