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CAS No. : | 204078-26-2 | MDL No. : | MFCD11145772 |
Formula : | C10H12N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 160.22 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
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With triethylamine In toluene at 20℃; for 0.583333h; |
Yield | Reaction Conditions | Operation in experiment |
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With sodium carbonate In methanol Heating; |
Yield | Reaction Conditions | Operation in experiment |
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In methanol Heating; |
Yield | Reaction Conditions | Operation in experiment |
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30% | With potassium carbonate In dimethyl sulfoxide at 100℃; for 16h; | 146.1 A solution mixture of 4-fluorobenzonitrilre (3.0 g, 24.79 mmol), isopropylamine (10 mL,122.l4mmol) and K2003 (3.41 g, 24.72 mmol) in DMSO (10 mL) was stirred at 100 CC for16 h. The reaction mixture was partitioned between water (50 mL) and ethyl acetate (2 x50 mL). The ethyl acetate layer was washed with brine (100 mL), dried over anhydrousNa2SO4 and concentrated to afford 1 .2 g (30 %) of 4-(isopropylamino)benzonitrlle 146-1as a white solid. 1H NMR (400 MHz, DMSO-d6): 7.42 (d, J= 8.8 Hz, 2H), 6.60 (d, J=8.8 Hz, 2H), 6.53 (d, J= 7.4 Hz, 1H), 3.56-3.64 (m, 1H), 1.13 (d, J= 6.6 Hz, 6H). |
R.4 4-Isopropylaminobenzonitrile REFERENCE EXAMPLE 4 4-Isopropylaminobenzonitrile By using the same method as described in Reference Example 3, the subject compound is synthesised from 4-fluorobenzonitrile and isopropylamine. 1H-NMR (CDCl3) δ (ppm): 1.23 (6H, d, J=6.6 Hz), 3.61-3.69 (1H, m), 4.22 (1H, br), 6.53 (2H, d, J=8.9 Hz), 7.38 (2H, d, J=8.9 Hz). | ||
R.4 4-Isopropylaminobenzonitrile REFERENCE EXAMPLE 4 4-Isopropylaminobenzonitrile According to a similar manner to that in Reference Example 3, the title compound was synthesised from 4-fluorobenzonitrile and isopropylamine. 1 H-NMR (CDCl3) δ (ppm): 1.23(6H, d, J=6.6 Hz), 3.61-3.69(1H, m), 4.22(1H, br), 6.53(2H, d, J=8.9 Hz), 7.38(2H, d, J=8.9 Hz). |