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CAS No. : | 204452-91-5 | MDL No. : | MFCD06657573 |
Formula : | C11H16N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | KKTPPUNNCIHOFA-UHFFFAOYSA-N |
M.W : | 208.26 | Pubchem ID : | 17750176 |
Synonyms : |
|
Num. heavy atoms : | 15 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.55 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 3.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 60.89 |
TPSA : | 43.38 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.7 cm/s |
Log Po/w (iLOGP) : | 2.4 |
Log Po/w (XLOGP3) : | 1.23 |
Log Po/w (WLOGP) : | 0.84 |
Log Po/w (MLOGP) : | 1.08 |
Log Po/w (SILICOS-IT) : | 1.89 |
Consensus Log Po/w : | 1.49 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.0 |
Solubility : | 2.06 mg/ml ; 0.00991 mol/l |
Class : | Soluble |
Log S (Ali) : | -1.74 |
Solubility : | 3.8 mg/ml ; 0.0183 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -3.22 |
Solubility : | 0.126 mg/ml ; 0.000607 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.36 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With platinum(IV) oxide; hydrogen In ethanol at 20℃; for 18 h; | A solution of the acetal 1-4 (20.0 g; 97.9 mmol) in ethanol (400 mL) washydrogenated in the presence of Pt02 (778 mg) under one atmospheric pressure of hydrogen atroom temperature for 18 hours. The reaction mixture was filtered through Solka Floc® andwashed with a mixture of ethanol-H20 (1:2 v/v). The filtrate and washings were combined and concentrated in vacuo to remove ethanol. The product crystallized as the ethanol was removed. The crystals were filtered and dried in vacuo to give product 1-5 (18.7 g, 92percent); m.p. 91-92.5°C. ‘H NIVIR (300 MHz; CDC13): ö 7.08 (d, J= 7.4 Hz, 1H), 6.62 (d, J= 7.4 Hz, 1H), 5.07 (s, 2H;1H exchangeable with D20), 3.37-3.29 (m, 2H), 3.29 (s, 6H), 2.64 (t, J 6.3 Hz, 2H), and 1.86-1.78 (m, 2H).‘3CNIVIR(75.5 IVIHz; CDC13): ö 155.9, 153.0, 136.3, 116.0, 109.8, 103.9, 53.3, 41.5, 26.6, and21.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium phosphate;tris-(dibenzylideneacetone)dipalladium(0); XPhos; In 1,2-dimethoxyethane; at 90℃; for 12h; | Production Example 15 A mixture of <strong>[204452-91-5]7-dimethoxymethyl-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (500 mg), bromobenzene (0.55 ml), tris(dibenzylideneacetone)dipalladium (44 mg), dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (46 mg), potassium phosphate (2.04 g) and dimethoxyethane (10 ml) was stirred at 90C for 12 hours. The reaction mixture was spontaneously cooled to room temperature and extracted with ethyl acetate by adding water. The organic layer was washed with saturated sodium chloride aqueous solution and then dried with anhydrous magnesium sulfate. By removing the desiccant and evaporating the solvent under a reduced pressure, 7-(dimethoxymethyl)-1-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine (1.14 g) was obtained as a black oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
[0928] To a solution of phosgene (20% solution in toluene,0.186 ml, 0.353 mmol) in THF (2 ml) was added triethylamine(0.141 ml, 1.01 mmol). To the resulting white suspensionwas added a solution of <strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (intermediate 4, 70 mg, 0.336mmol) in THF (2 ml) drop wise. The resulting yellow suspensionwas stirred at room temperature for 1 h. 4,5-dichloropyridin-2-amine (65.7 mg, 0.403 mmol) in THF (1 ml) wasadded to the mixture and stirred at room temperature for 16 h.The reaction mixture was filtered through a silica gel plug andwashed with heptanes/EtOAc 1:1 (35 ml), the filtrate wasconcentrated. The residue was dissolved in dioxane (1 ml)and treated with HCl (4 Min dioxane, 1 ml, 4.0 mmol). Themixture was stirred at room temperature for 2 h, diluted withDCM and quenched with saturated aqueous NaHC03 . Theorg. layer was collected and the water layer was extractedwith DCM. The combined org. layers were dried over anhydrousNa2S04 and concentrated under reduced pressure. Thecrude product was dissolved in acetonitrile/NMP/TFA, filteredthrough a syringe filter (0.2 f.tm) and purified by preparativereverse phase LC-MS (RP 1). The clean fractionswere combined and lyophilized to obtain the title compoundas an off white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
[0543] To a solution of phosgene (20% solution in toluene, 0.265 ml, 0.504 mmol) in THF (2 ml) was added triethylamine (0.20 ml, 1.44 mmol). Subsequently, a solution of <strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (intermediate 4, 100 mg, 0.480 mmol) in THF (2 ml) was added drop wise. The resulting yellow suspension was stirred for 15 min, then 5-(trifluoromethyl)pyridin-2-amine (93 mg, 0.576 mmol) was added and the reaction mixture stirred for 2.5 days. The reaction mixture was diluted with sat. aq. NaHCO3 and extracted twice with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude material was purified by normal phase chromatography (12 g silica gel cartridge, heptanes/EtOAc 100:0 to 0:100). The product containing fractions were concentrated to give the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 13.83 (s, 1H), 8.70 (s, 1H), 8.26 (d, 1H), 8.20-8.12 (m, 1H), 7.73 (d, 1H), 7.18 (d, 1H), 5.37 (s, 1H), 4.01-3.93 (m, 2H), 3.39 (s, 6H), 2.86 (t, 2H), 1.98-1.87 (m, 2H). (UPLC-MS 1) tR 1.29 min; ESI-MS 397.0 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium hexamethyldisilazane; In tetrahydrofuran; at -15℃; for 0.5h; | [0567] A solution of7 -( dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (intermediate 4, 2 g, 9.60 mmol) anddiphenylcarbonate ( 4.11 g, 19.21 mmol) in THF ( 40 ml) at-15 C. was treated with LHMDS (1M in THF, 13.3 ml, 13.3mmol) over 0.5 h. The reaction mixture was quenched withsat. aq. NH4Cl, extracted with EtOAc (2x). The combinedorganic layers were washed with brine, dried over Na2S04 ,filtered and concentrated under reduced pressure. The crudeproduct was purified by normal phase chromatography (80 gsilica gel cartridge, heptanes/EtOAc 100:0 to 25:75) to givethe title compound as a pale yellow solid. 1H-NMR (400MHz, DMSO-d6 ) o7.65 (d, lH), 7.46-7.38 (m, 2H), 7.27-7.18 (m, 4H), 5.17 (s, lH), 3.87-3.80 (m, 2H), 3.26 (s, 6H), 2.83(t, 2H), 2.00-1.92 (m, 2H). | |
With lithium hexamethyldisilazane; In tetrahydrofuran; at -15℃; for 0.5h; | A solution of 7-(dimethoxymethyl)-1 ,2,3,4-tetrahydro-1 ,8-naphthyridine (intermediate 4, 2 g, 9.60mmol) and diphenylcarbonate (4.11 g, 19.21 mmol) in THF (40 ml) at -15 C was treated withLHMDS (IM in THF, 13.3 ml, 13.3 mmol) over 0.5 h. The reaction mixture was quenched with sat.aq. NH4CI, extracted with EtOAc (2x). The combined organic layers were washed with brine, driedover Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by normal phase chromatography (80 g silica gel cartridge, heptanes/EtOAc 100:0 to 25:75) to give the title compound as a pale yellow solid. 1H-NMR (400 MHz, DMSO-d6) 5 7.65 (d, I H), 7.46 - 7.38 (m, 2 H), 7.27 - 7.18 (m, 4H), 5.17 (s, I H), 3.87 - 3.80 (m, 2 H), 3.26 (s, 6 H), 2.83 (t, 2 H), 2.00-1.92(m,2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | With N-Bromosuccinimide; In acetonitrile; at 20℃; for 0.5h; | The compound (12 g, 57.6 mmol) prepared in the above step 2 was dissolved in acetonitrile (192 ml), and N-bromosuccinimide (NBS) (10.77 g, 60.5 mmol) was slowly added at room temperature. After the reaction mixture was stirred at room temperature for 30 minutes, And concentrated under reduced pressure. After extracting the reaction residue obtained from the above with diethyl ether and ice water, The organic layer was washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by MPLC to obtain yellow To give the desired compound (11 g, 66%). |
With N-Bromosuccinimide; In acetonitrile; at 25℃; for 0.5h; | [0578] Into a 3 I 4-necked round-bottom flask was placed7 -( dimethoxymethyl)-1 ,2,3,4-tetrahydro-1 ,8-naphthyridine(intermediate 4, 114.6 g, 550.3 mmol) in acetonitrile (2 1).This was followed by the addition of NBS (1 03 g, 578 mol) inportions with stirring at 25 C. The resulting solution wasstirred for 30 min at 25 C. The resulting mixture was concentratedunder vacuum and the residue was diluted with1000 ml of diethylether. The mixture was washed with 3xl 00ml of ice/water. The aqueous phase was extracted with 2xl 00ml of diethylether and the organic layers were combined. Theresulting mixture was washed with lxlOO ml of brine, driedover sodium sulfate and concentrated under vacuum to givethe title compound as a light yellow solid. LC-MS: (ES, m/z):[0579] 286.03 [M+Ht. 1H-NMR: (300 MHz, CDCI3 ) o1.86-1.94 (2H, m), 2.70-2.74 (2H, m), 3.9-3.43 (2H, m), 3.47(6H, s), 5.23 (lH, s), 5.58 (lH, s), 7.29 (lH, s). | |
With N-Bromosuccinimide; In acetonitrile; at 25℃; for 0.5h; | Into a 3 I 4-necked round-bottom flask was placed 7-(dimethoxymethyl)-1 ,2,3,4-tetrahydro-1 8- naphthyridine (intermediate 4, 114.6 g, 550.3mmol) in acetonitrile (2 I). This was followed by theaddition of NBS (103 g, 578 mol) in portions with stirring at 25 C. The resulting solution was stirred for 30 mm at 25 C. The resulting mixture was concentrated under vacuum and the residue was diluted with 1000 ml of diethylether. The mixture was washed with 3x100 ml of ice/water. The aqueous phase was extracted with 2x1 00 ml of diethylether and the organic layers were combined. The resulting mixture was washed with lxlOO ml of brine, dried over sodium sulfate andconcentrated under vacuum to give the title compound as a light yellow solid. LC-MS: (ES, m/z):286.03 [M+H]. 1H-NMR: (300MHz, CDCI3) 5 1.86 - 1.94 (2H, m), 2.70 - 2.74 (2H, m), 3.9 - 3.43 (2H, m), 3.47 (6H, s), 5.23 (IH, s), 5.58 (IH, s), 7.29 (IH, s). |
With N-Bromosuccinimide; In acetonitrile; at 25℃; for 0.5h; | Into a 3 I 4-necked round-bottom flask was placed 7-(dimethoxymethyl)-1 ,2,3,4- tetrahydro-1 ,8-naphthyridine (intermediate 4, 1 14.6 g, 550.3mmol) in acetonitrile (2 I). This was followed by the addition of NBS (103 g, 578 mol) in portions with stirring at 25 C. The resulting solution was stirred for 30 min at 25 C. The resulting mixture was concentrated under vacuum and the residue was diluted with 1000 ml of diethylether. The mixture was washed with 3x100 ml of ice/water. The aqueous phase was extracted with 2x100 ml of diethylether and the organic layers were combined. The resulting mixture was washed with 1 x100 ml of brine, dried over sodium sulfate and concentrated under vacuum to give the title compound as a light yellow solid. LC-MS: (ES, m/z): 286.03 [M+H]+. 1H-NMR: (300MHz, CDCI3) delta 1 .86 - 1 .94 (2H, m), 2.70 - 2.74 (2H, m), 3.9 - 3.43 (2H, m), 3.47 (6H, s), 5.23 (1 H, s), 5.58 (1 H, s), 7.29 (1 H, s). | |
With N-Bromosuccinimide; In acetonitrile; at 25℃; for 0.5h; | Into a 3 L 4-necked round-bottom flask was placed 7-(dimethoxymethyl)-1 ,2,3, 4-tetrahydro-1 ,8- naphthyridine (1 14.6 g, 550.3mmol) in acetonitrile (2 L). This was followed by the addition of NBS (103 g, 578 mol) in portions with stirring at 25 C. The resulting solution was stirred for 30 min at 25 C. The resulting mixture was concentrated under vacuum and the residue was diluted with 1000 mL of diethylether. The mixture was washed with 3x100 mL of ice/water. The aqueous phase was extracted with 2x100 mL of diethylether and the organic layers were combined. The resulting mixture was washed with 1x100 mL of brine, dried over sodium sulfate and concentrated under vacuum to give the title compound as a light yellow solid. LC-MS: (ES, m/z): 286.03 [M+H]+. 1 H- NMR: (300MHz, CDCI3) delta 1 .86 - 1 .94 (2H, m), 2.70 - 2.74 (2H, m), 3.9 - 3.43 (2H, m), 3.47 (6H, s), 5.23 (1 H, s), 5.58 (1 H, s), 7.29 (1 H, s). | |
9.37 g | With N-Bromosuccinimide; In acetonitrile; at 20℃; | The compound 30 Kappa (12.0 g, 57.6 mmol) was dissolved in acetonitrile (200 ml), and NBS (10.25 g,57.6 mmol) was then reacted at room temperature and the reaction was monitored by thin layer chromatography.After concentrating under reduced pressure, the mixture was evaporated, evaporated, evaporated, evaporated, evaporated, evaporated. 9.37g). |
With N-Bromosuccinimide; In acetonitrile; at 20℃; for 1h; | Step 3: Preparation of 6-bromo-<strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> NBS (38.3 g, 215 mmol) was added in batches to a solution of <strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (42.7 g, 205 mmol) in MeCN (1 L) at room temperature. The reaction solution stirred for 1 hour and concentrated. The resulting residue was dissolved in CH2Cl2, washed with 1 M NaOH aqueous solution and saturated brine successively, dried over anhydrous sodium sulfate and concentrated. The resulting residue was subjected to column chromatography to obtain the title compound 6-bromo-<strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (47.5 g, total yield of three steps: 81%). 1H NMR (400 MHz, CDCl3): delta 7.27 (s, 1H), 5.55 (s, 1H), 5.39 (br s, 1H), 3.45 (s, 6H), 3.38 (m, 2H), 2.70 (t, J = 6.0 Hz, 2H), 1.88 (m, 2H); MS m/z (ESI): 287.0 [M+H]+. | |
47.5 g | With N-Bromosuccinimide; In acetonitrile; at 20℃; for 1h;Inert atmosphere; | NBS (38.3 g, 215 mmol) was added in batches to a solution of <strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong> (42.7 g, 205 mmol) in MeCN (1 L) at room temperature. The reaction solution was stirred for 1 hour andconcentrated. The resulting residue was dissolved in CH2Cl2, washed with 1 M aqueous NaOH solution and saturatedbrine successively, dried over anhydrous sodium sulfate and concentrated. The resulting residue was subjected tocolumn chromatography to obtain the title compound 6-bromo-<strong>[204452-91-5]7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine</strong>(47.5 g, total yield of three steps: 81%).1H NMR (400 MHz, CDCl3): delta 7.27 (s, 1H), 5.55 (s, 1H), 5.39 (br s, 1H), 3.45 (s, 6H), 3.38 (m, 2H), 2.70 (t, J = 6.0 Hz,2H), 1.88 (m, 2H);MS m/z (ESI): 287.0 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-iodo-succinimide; In acetonitrile; for 4h; | [0673] A solution of7 -( dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine (intermediate 4, 1 g, 4.8 mmol) inMeCN (15 ml) was treated with NIS (1.13 g, 5.04 mmol),stirred for 4 h in a flask covered with aluminum foil. Them,the reaction mixture was concentrated. The residue wastreated with Et20 and DCM, washed with water (2x) andbrine, dried over Na2S04 , filtered and concentrated.[0674] The crude material was purified by normal phasechromatography (80 g silica gel cartridge, heptanes/EtOAc100:0 to 0:1 00) to give the title compound as a yellow oil.(UPLC-MS 3) tR 0.73 min; ESI-MS 335.3 [M+Ht. | |
With N-iodo-succinimide; In acetonitrile; for 4h; | A solution of 7-(dimethoxymethyl)-I ,2,3,4-tetrahydro-I ,8-naphthyridine (intermediate 4, 1 g, 4.8 mmol) in MeCN (15 ml) was treated with NIS (1.13 g, 5.04 mmol), stirred for4 h in a flask coveredwith aluminum foil. Them, the reaction mixture was concentrated. The residue was treated with Et20 and DCM, washed with water (2x) and brine, dried over Na2SO4, filtered and concentrated. The crude material was purified by normal phase chromatography (80 g silica gel cartridge, heptanes/EtOAc 100:0 to 0:100) to give the title compound as a yellow oil. (UPLC-MS 3) tR 0.73 mm; ES I-MS 335.3 [M+H]. |
Tags: 204452-91-5 synthesis path| 204452-91-5 SDS| 204452-91-5 COA| 204452-91-5 purity| 204452-91-5 application| 204452-91-5 NMR| 204452-91-5 COA| 204452-91-5 structure
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P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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