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[ CAS No. 204782-93-4 ] {[proInfo.proName]}

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Chemical Structure| 204782-93-4
Chemical Structure| 204782-93-4
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Product Details of [ 204782-93-4 ]

CAS No. :204782-93-4 MDL No. :MFCD20658731
Formula : C10H6FNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 191.16 Pubchem ID :-
Synonyms :

Safety of [ 204782-93-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 204782-93-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 204782-93-4 ]

[ 204782-93-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 204782-93-4 ]
  • trans-3-(2-(1-(4-amino)cyclohexyl)ethyl)-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine [ No CAS ]
  • trans-7-cyano-3-(2-(1-(4-(5-(8-fluoro)quinolinyl)carboxamido)cyclohexyl)ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepine [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 18h; 21 A mixture of trans-3- (2- (1- (4-amino) cyclohexyl) ethyl)-7-cyano-2, 3,4, 5-tetrahydro- 1 H 3-benzazepine (0.162 g, 0.545 mmol), 8-fluoroquinoline-5-carboxylic acid (0.115 g, 0.6 mmol), 1- (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.115 g, 0.6 mmol) and 1-hydroxybenzotriazole hydrate (0.01 g, 0.065 mmol) in dichloromethane (7 ml) was shaken for 18 h. Saturated aqueous sodium hydrogen carbonate (6 ml) was added and shaking continued for 0.5 h. The organic layer was separated and pipetted onto a column of silica (10 g). Elution with 30-100% ethyl acetate-hexane gradient then 1-10% methanol-ethyl acetate gradient yielded the title compound as a colourless solid (0.22 g, 85%). Mass spectrum (API+) : Found 471 (MH+). C2gH31 FN40 requires 470. 1 H NMR (CDCI3) 8 : 1.05-1. 40 (5H, m), 1.45 (2H, m), 1.85 (2H, m), 2.20 (2H, m), 2.55 (2H, m), 2.63 (4H, m), 2.96 (4H, m), 4.00 (1H, m), 5.86 (1H, d, J = 8 Hz), 7.17 (1 H, d, J = 8 Hz), 7.30-7. 45 (3H, m), 7.54 (1 H, m), 7.62 (1 H, m), 8.80 (1 H, d, J = 8 Hz), 9.01 (1H, m).
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