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Chemical Structure| 205448-48-2 Chemical Structure| 205448-48-2

Structure of 205448-48-2

Chemical Structure| 205448-48-2

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Product Details of [ 205448-48-2 ]

CAS No. :205448-48-2
Formula : C11H9ClFNO2
M.W : 241.65
SMILES Code : COC1=C(OC)C=C2C(Cl)=C(F)C=NC2=C1
MDL No. :MFCD18073191

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Application In Synthesis of [ 205448-48-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 205448-48-2 ]

[ 205448-48-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 205448-48-2 ]
  • [ 84478-72-8 ]
  • [ 205447-99-0 ]
YieldReaction ConditionsOperation in experiment
37% In pentanol, 2-; for 15h;Heating / reflux; EXAMPLE 14 <strong>[84478-72-8]4-Chloro-2-fluoro-5-hydroxyaniline</strong> (194 mg, 1.2 mmol), (as described in EP 61741 A2), was added to a suspension of 4-chloro-6,7-dimethoxy-3-fluoroquinoline (241 mg, 1 mmol) in 2-pentanol (5 ml).. After refluxing for 15 hours, the precipitate was collected by filtration, washed with isopropanol and dried under vacuum.. The solid was partitioned between ethyl acetate and aqueous sodium hydrogen carbonate.. The organic layer was washed with water, brine, dried (MgSO4) and the volatiles were removed by evaporation.. The residue was purified by column chromatography eluding with methylene chloride/methanol 95/5.. The purified product was dissolved in methylene chloride/isopropanol and 5M hydrogen chloride in isopropanol (0.5 ml) was added.. After evaporation of the methylene chloride, the precipitate was collected by filtration, washed with isopropanol, followed by ether and dried under vacuum to give 6,7-dimethoxy-3-fluoro-4-(4-chloro-2-fluoro-hydroxyanilino)quinoline hydrochloride (150 mg, 37%). 1H NMR Spectrum: (DMSOd6) 3.98 (s, 3H); 3.99 (s, 3H); 7.12 (d, 1H); 7.46 (s, 1H); 7.49 (d,
 

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