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Chemical Structure| 207726-35-0 Chemical Structure| 207726-35-0

Structure of 207726-35-0

Chemical Structure| 207726-35-0

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Product Details of [ 207726-35-0 ]

CAS No. :207726-35-0
Formula : C20H23ClN2O3
M.W : 374.86
SMILES Code : CCOC(=O)N1CCC(CC1)OC(C1=CC=C(Cl)C=C1)C1=NC=CC=C1
MDL No. :MFCD13184722
InChI Key :IGEIRAKLLHYWTQ-UHFFFAOYSA-N
Pubchem ID :46856356

Safety of [ 207726-35-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 207726-35-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 207726-35-0 ]

[ 207726-35-0 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 27652-89-7 ]
  • [ 65214-82-6 ]
  • [ 207726-35-0 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; In toluene; at 112℃; for 7h; Ethoxycarbonyl-4-piperidinol(According to the addition amount of N-ethoxycarbonyl-4-piperidinol, as the first to fifthGroup, the specific amount of added and the amount of added substances in Table 1) N-ethoxycarbonyl-4-piperidinol added to 500 ml four bottles,Join300 ml of toluene,3 g of 98percent concentrated sulfuric acid, and then 60 g (0.273 mol)? - (4-chlorophenyl) -2-pyridinemethanol,The reaction was heated to reflux (temperature 112 ° C), and the reaction was continued at that temperature for 7 hours. After completion of the TLC monitoring, the reaction was stopped and the reaction was stoppedThe organic phase was washed with 100 ml of water * 2 and the organic phase was concentrated under reduced pressure to give 4 - [(4-chlorophenyl) (2-pyridyl) methoxy]1-carboxylic acid ethyl ester as an oil which was used in the next step without further purification.
  • 3
  • [ 27652-89-7 ]
  • C8H14ClNO2 [ No CAS ]
  • [ 207726-35-0 ]
YieldReaction ConditionsOperation in experiment
91.6% With sodium iodide; In toluene; for 6h;Reflux; A compound of formula II (X = Cl, R = Et) (200 g, 910.5 mmol) was added to a 10 L four-necked flask.Then, anhydrous toluene (3 L) was added. After stirring, the system was added with NaI (1.36 g, 9.1 mmol), and then a solution of the compound of formula I (185 g, 965 mmol) in anhydrous toluene (2 L) was added.After the addition, the system was heated to reflux for 6 hours.After the reaction was completed, the system was naturally cooled to room temperature. The toluene was distilled off under reduced pressure.Then the system was added with CH2Cl2 (2.5 L), and after stirring, the system was added with H2O (1 L) and stirred for 10 minutes.The system is then allowed to stand and the organic phase is separated. The aqueous phase was extracted with CH 2 Cl 2 (2×300 mL).Combine the organic phases. The organic phase was washed with 2percent aqueous saturated sodium bicarbonate (300 mL).Dry over anhydrous sodium sulfate, filter, and distill off the organic phase under reduced pressure.The compound of formula III (R = Et) (312.6 g, 91.6percent) was obtained.
 

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