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Chemical Structure| 208121-91-9 Chemical Structure| 208121-91-9

Structure of 208121-91-9

Chemical Structure| 208121-91-9

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Product Details of [ 208121-91-9 ]

CAS No. :208121-91-9
Formula : C11H10FNO3
M.W : 223.20
SMILES Code : O=C(C1(NC(C2=CC=C(F)C=C2)=O)CC1)O
MDL No. :MFCD21236908

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Application In Synthesis of [ 208121-91-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 208121-91-9 ]

[ 208121-91-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 208121-91-9 ]
  • [ 123-30-8 ]
  • [ 849217-60-3 ]
YieldReaction ConditionsOperation in experiment
87% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 3h; 4-Aminophenol (15, 0.59 g, 5.38 mmol) and Intermediate 3 (1 g, 4.48 mmol) were dissolved in 15 mL of DMF, EDC.HCl (1.03 g, 5.38 mmol) was added thereto, and the mixture was stirred at room temperature for 3 h.After the reaction was completed, water was added to the reaction solution to precipitate a white solid, and 1N HCl was added to adjust the pH to 4.0 to 5.0. After stirring for 15 minutes, the mixture was filtered, and the filter cake was washed with water until neutral, and dried under vacuum to obtain 1.23 g of a white solid. The yield was 87.9. %.
 

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