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Chemical Structure| 208124-34-9 Chemical Structure| 208124-34-9

Structure of 208124-34-9

Chemical Structure| 208124-34-9

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Product Details of [ 208124-34-9 ]

CAS No. :208124-34-9
Formula : C11H11F2NO3
M.W : 243.21
SMILES Code : C[C@@H](C(O)=O)NC(CC1=CC(F)=CC(F)=C1)=O

Safety of [ 208124-34-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 208124-34-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 208124-34-9 ]

[ 208124-34-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 209984-08-7 ]
  • [ 19832-98-5 ]
  • [ 208124-34-9 ]
  • 3-(N'-(3,5-difluorophenylacetyl)-L-alaninyl)amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 6-8 Synthesis of 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one Following General Procedure C above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (prepared from 4-methyltetralone (Aldrich) using General Procedure 6-A), the title compound was prepared as a solid having a melting point of 115-119 C. Purification was by flash chromatography using 5% methanol/dichloromethane as the eluant. NMR data was as follows: 1H-nmr (CDCl3): delta=7.2-7.0 (m, 5H), 6.8-6.5 (m, 4H), 4.5 (m, J=7 Hz, 1H), 4.3 (m, J=4 Hz, 1H), 3.5 (s, 2H), 3.35 (s, 3H), 3.05 (m, J=6.5 Hz, 1H), 2.2 (m, J=4.5 Hz, 1H), 1.95 (m, 1H), 1.3 (2xd, J=7 Hz, 6H). 13C-nmr (CDCl3): delta=172.3, 166.4, 165.9, 164.4, 164.3, 160.0, 159.9, 156.6, 139.9, 136.4, 133.6, 133.2, 122.8, 122.4, 120.5, 118.1, 107.6, 107.3, 98.2, 97.9, 97.5, 95.5, 45.0, 44.9, 44.0, 43.9, 39.8, 39.7, 37.9, 30.7, 30.7, 26.0, 14.0, 13.8, 12.4.
 

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