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Chemical Structure| 20886-13-9 Chemical Structure| 20886-13-9

Structure of 20886-13-9

Chemical Structure| 20886-13-9

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Product Details of [ 20886-13-9 ]

CAS No. :20886-13-9
Formula : C11H11NO2
M.W : 189.21
SMILES Code : O=C1NC2=C(C=CC=C2)C(OCC)=C1

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Application In Synthesis of [ 20886-13-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20886-13-9 ]

[ 20886-13-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52851-41-9 ]
  • [ 75-03-6 ]
  • [ 20886-13-9 ]
YieldReaction ConditionsOperation in experiment
In ISOPROPYLAMIDE; water; mineral oil; Step A: Preparation of 4-ethoxyquinolin-2(1H)-one. To a suspension of 6 g. of <strong>[52851-41-9]quinoline-2,4-dione</strong> in 50 ml. of dimethylacetamide is added 1.6 g. of sodium hydride (56% in mineral oil, pentane washed). The mixture is then stirred at room temperature for 90 minutes and 6 g. of ethyliodide is added and the resulting mixture is heated briefly at 35 C. followed by stirring at ambient temperature for 18 hours. The precipitate which forms is recovered by filtering and the filtrate is poured into 200 ml. of water and the resulting precipitate also recovered by filtering and dried. The two filter cakes above obtained are combined and crystallized from methanol to obtain 4-ethoxyquinolin-2(1H)-one, m.p. 223-226 C.
 

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