Alternatived Products of [ 209353-22-0 ]
Product Details of [ 209353-22-0 ]
CAS No. : | 209353-22-0 |
MDL No. : | MFCD18377723 |
Formula : |
C9H6FNO
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | ATQMMXTUQMSGLY-UHFFFAOYSA-N |
M.W : | 163.15 |
Pubchem ID : | 15306313 |
Synonyms : |
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Safety of [ 209353-22-0 ]
Application In Synthesis of [ 209353-22-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 209353-22-0 ]
- 1
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[ 107-30-2 ]

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[ 209353-22-0 ]

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[ 209353-20-8 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium hydride 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h; Yield given. Multistep reaction; |
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- 2
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[ 209353-21-9 ]

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[ 209353-22-0 ]
Yield | Reaction Conditions | Operation in experiment |
89% |
With hydrogen bromide for 8h; Heating; |
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- 3
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[ 458-52-6 ]

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peroxysulfuric acid
[ No CAS ]

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[ 209353-22-0 ]
- 4
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[ 394-42-3 ]

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[ 209353-22-0 ]
- 5
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[ 209353-22-0 ]

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2-Butyl-8-fluoro-6-methoxymethoxy-quinoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 2.) TMS-triflate / 1.) THF, -78 deg C, 2 h; 2.) THF, -78 deg C to 0 deg C |
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- 6
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[ 209353-22-0 ]

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2-tert-Butyl-8-fluoro-6-methoxymethoxy-quinoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 2.) TMS-triflate / 1.) THF, -78 deg C, 2 h; 2.) THF, -78 deg C to 0 deg C |
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- 7
-
[ 209353-22-0 ]

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8-Fluoro-6-methoxymethoxy-7-trimethylsilanyl-quinoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 2.) TMS-triflate / 1.) THF, -78 deg C, 2 h; 2.) THF, -78 deg C to 0 deg C |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) THF, -78 deg C, 6 h; 2.) THF, -78 deg C to 0 deg C |
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Reference:
[1]Stadlwieser, Josef; Barbier, Pierre; Taylor, Sven
[Helvetica Chimica Acta, 1998, vol. 81, # 6, p. 1088 - 1094]
[2]Stadlwieser, Josef; Barbier, Pierre; Taylor, Sven
[Helvetica Chimica Acta, 1998, vol. 81, # 6, p. 1088 - 1094]
- 8
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[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(8-fluoro-6-methoxymethoxy-2-methyl-quinolin-7-yl)-methanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min
3: MnO2 / CH2Cl2 / 16 h / Ambient temperature |
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- 9
-
[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(8-fluoro-6-methoxymethoxy-2-methyl-1,2-dihydro-quinolin-7-yl)-methanol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min |
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- 10
-
[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(2-tert-butyl-8-fluoro-6-methoxymethoxy-quinolin-7-yl)-methanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min
3: MnO2 / CH2Cl2 / 16 h / Ambient temperature |
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- 11
-
[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(2-butyl-8-fluoro-6-methoxymethoxy-quinolin-7-yl)-methanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min
3: MnO2 / CH2Cl2 / 16 h / Ambient temperature |
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- 12
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[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(2-tert-butyl-8-fluoro-6-methoxymethoxy-1,2-dihydro-quinolin-7-yl)-methanol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min |
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- 13
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[ 209353-22-0 ]

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[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-(2-butyl-8-fluoro-6-methoxymethoxy-1,2-dihydro-quinolin-7-yl)-methanol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, DMF, 30 min; 2.) THF, DMF, 30 deg C, 1 h
2: 1.) MeLi / 1.) Et2O, THF, -78 deg C, 6 h; 2.) THF, Et2O, -78 deg C, 30 min; 3.) THF, Et2O, -78 deg C, 15 min, -15 deg C, 30 min |
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- 14
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[ 209353-23-1 ]

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[ 209353-22-0 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: 80.6 percent / HCl (gas) / methanol
2: 37.86 percent / arsenic(V) oxide hydrate, boric acid, conc. H2SO4 / 16 h / 120 °C
3: 89 percent / 48percent aq. HBr / 8 h / Heating |
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